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Category: neuroscience

In a trailblazing advancement in cancer therapy, researchers at Korea Advanced Institute of Science and Technology (KAIST) have developed a technology that transforms colon cancer cells into normal-like cells without destroying them.

This innovative approach, led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, represents a significant departure from traditional cancer treatments that rely on killing cancer cells, often leading to severe side effects and risks of recurrence.

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While his neighbors frantically fled from their oncoming doom, one man stayed in bed. For whatever reason, he didn’t join the other 2000 residents of Herculaneum—the ancient Roman city just north of Pompeii—as they ran from erupting Mount Vesuvius. The first scorching cloud of ash passed through the city so quickly, it turned his brain into black, glasslike shards. Now, a new analysis of these shards, published today in, offers clues about how the man and his neighbors perished in 79 C.E.

Until recently, scientists believed the people of Herculaneum were annihilated by Mount Vesuvius’s avalanche of hot rock, ash, and gas that buried their city, along with Pompeii. But when researchers announced the discovery of those black, glossy chips in 2020, a new culprit emerged: a swift ash cloud preceding this flood of debris. This rethink, however, hinged on whether the brain had indeed turned to glass.

For glass to form, a liquid needs to be cooled so rapidly that its molecules suddenly “freeze” into a rigid structure rather than forming crystals. For this reason, glass is sometimes referred to as a “liquid solid,” says Brian Wowk, a cryobiologist at 21st Century Medicine who was not involved with the work. Thick blankets of pyroclastic flow–the torrent of rocks, ash, and gas expelled by volcanos–cool off far too slowly for glass to form, says study co-author Guido Giordano, a volcanologist at the Roma Tre University. “Once they’re in place, they can take years to cool down.”

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The hippocampus is essential for episodic memory, yet its coding mechanism remains debated. In humans, two main theories have been proposed: one suggests that concept neurons represent specific elements of an episode, while another posits a conjunctive code, where index neurons code the entire episode. Here, we integrate new findings of index neurons in humans and other animals with the concept-specific memory framework, proposing that concept neurons evolve from index neurons through overlapping memories. This process is supported by engram literature, which posits that neurons are allocated to a memory trace based on excitability and that reactivation induces excitability. By integrating these insights, we connect two historically disparate fields of neuroscience: engram research and human single neuron episodic memory research.

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In this work, I present a coherent and comprehensive argument for the nature of consciousness as the inherent ground of phenomena backed by experimental evidence confirming the predictions make by this hypothesis.

This argument makes its point by establishing an equivalence between all observers, generating a set of observational and mathematical predictions which were then tested and confirmed.

Furthermore, when the core tenet of the argument is accepted, it provides clear, testable explanations for most of the curently unresolved questions regarding consciousness, intelligence, and the nature of observed phenomena.

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In human engineering, we design systems to be predictable and controlled. By contrast, nature thrives on systems where simple rules generate rich, emergent complexity. The computational nature of the universe explains how simplicity can generate the complexity we see in natural phenomena. Imagine being able to understand everything about the universe and solve all its mysteries by a computational approach that uses very simple rules. Instead of being limited to mathematical equations, using very basic computational rules, we might be able to figure out and describe everything in the universe, like what happened at the very beginning? What is energy? What’s the nature of dark matter? Is traveling faster than light possible? What is consciousness? Is there free will? How can we unify different theories of physics into one ultimate theory of everything?

This paradigm goes against the traditional notion that complexity in nature must arise from complicated origins. It claims that simplicity in fundamental rules can produce astonishing complexity in behavior. Entering the Wolfram’s physics project: The computational universe!

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A smartphone’s glow is often the first and last thing we see as we wake up in the morning and go to sleep at the end of the day. It is increasingly becoming an extension of our body that we struggle to part with. In a recent study in Computers in Human Behavior, scientists observed that staying away from smartphones can even change one’s brain chemistry.

The researchers recruited for a 72-hour smartphone restriction diet where they were asked to limit to essential tasks such as work, , and communication with their family or significant others.

During these three days, the researchers conducted psychological tests and did brain scans using imaging (fMRI) to examine the effects of restricting phone usage. Brain scans showed significant activity shifts in reward and craving regions of the brain, resembling patterns seen in substance or alcohol addiction.

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For the first time, researchers have identified that inflammation—long associated with multiple sclerosis (MS)—appears to cause increased mutations linked to MS progression.

MS is a progressive neurological disease that affects 33,000 Australians and three million people worldwide. About one-third of people living with MS have progressive disease, which current treatments do not address effectively.

The researchers studied MS brain lesions, visible as spots on MRI scans, which are areas of past or ongoing brain inflammation. They found located in MS brain lesions have a that is two-and-a-half times faster than in normal neurons.

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The human brain continuously processes the wide range of information it acquires from the outside world. Over time, this information is organized into mental representations, referred to as “schema,” which help us to understand what is happening at a given time and make predictions about what will happen next.

Temporal schemas are that specifically outline the order in which specific events occur. For instance, when attending a wedding, temporal schemas could allow us to anticipate the order in which different parts of the ritual (e.g., the arrival of the bride, the exchange of vows, etc.) will take place.

Researchers at Tilburg University and Princeton University recently carried out a study aimed at further exploring how the brain represents these structured sequences of events.

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In the annals of scientific inquiry, few endeavors have been as audacious as the attempt to bridge the chasm between the tangible and the intangible, the empirical and the experiential. The declassification of the 1983 U.S. Army Intelligence report, “Analysis and Assessment of The Gateway Process,” offers a compelling case study in this regard. Authored by Lieutenant Colonel Wayne M. McDonnell, the report delves into altered states of consciousness, suggesting that human consciousness may transcend the physical plane, potentially supporting concepts akin to reincarnation. This proposition invites us to explore the intersection of infodynamics — the study of information dynamics within physical systems — and phenomena traditionally deemed spiritual, under the premise that all such phenomena are rooted in the natural order.

At the heart of this exploration lies the principle that information, much like energy, is conserved within the universe. This concept is reminiscent of the first law of thermodynamics, which asserts that energy cannot be created or destroyed, only transformed. In the realm of information theory, this translates to the idea that information persists, undergoing transformations but never facing annihilation. This perspective aligns with the notion that consciousness, as a form of information, may continue beyond the cessation of its current physical embodiment.

Quantum mechanics further enriches this discourse. The phenomenon of quantum entanglement, wherein particles become interconnected in such a way that the state of one instantaneously influences the state of another, regardless of the spatial separation, challenges our classical understanding of locality and separability. This non-locality suggests a deeply interconnected fabric of reality, where information is not confined to a singular point in space or time. Such a framework provides a plausible basis for understanding how consciousness, as an informational construct, could transcend individual physical forms, offering a naturalistic foundation for phenomena like reincarnation.

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