Cancer immunotherapy strategy equips T cells with molecular GPS that lets them home in on brain tumors and sites of neuroinflammation.
Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.
In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino acids — can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.
This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.
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Aging happens in distinct stages marked by synchronized cellular changes across organs, as shown in Rockefeller’s largest-ever mammalian aging atlas. Their findings offer clues for targeting aging processes and reveal key age and sex differences in cellular dynamics.
If you compared photos of a maple tree taken in July and December, the difference would be striking: a vibrant green canopy in summer versus bare, stark branches in winter. What those images wouldn’t reveal is how the transformation unfolded—whether it was gradual or sudden. In reality, deciduous trees usually wait for environmental cues, such as changes in light or temperature, before shedding all their leaves within a brief span of one to two weeks.
When it comes to aging, we may be more like these trees than we realized.
The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.
Aging is an inevitable aspect of life, but age-related diseases are not an inseparable part of the aging process, and their risk can be reduced through a healthy lifestyle. Vitamin K has a broader impact than just blood clotting, and yet it remains overshadowed by other vitamins and underestimated by both doctors and consumers. Vitamin K (VK) is a multifunctional micronutrient with anti-inflammatory and antioxidant properties, whose deficiency may cause age-related diseases such as cardiovascular diseases, neurodegenerative diseases and osteoporosis. There is a growing body of evidence supporting the role of vitamin K as a protective nutrient in aging and inflammation. This review summarizes the current knowledge regarding the molecular aspects of the protective role of vitamin K in aging and age-related diseases and its clinical implications.
Understanding unfolded proteins could boost drug discovery and decipher origins of life mysteries.
An initially “unknown” illness affecting hundreds in the Democratic Republic of the Congo may be attributable to malaria, malnutrition and a viral infection. But investigations are ongoing.
In recent years, roboticists have developed a wide range of systems that could eventually be introduced in health care and assisted living facilities. These include both medical robots and robots designed to provide companionship or assistance to human users.
Researchers at Shanghai Jiao Tong University and the University of Shanghai for Science and Technology recently developed a robotic system that could give human users a massage that employs traditional Chinese medicine (TCM) techniques. This new robot, introduced in a paper on the arXiv preprint server, could eventually be deployed in health care, wellness and rehabilitation facilities as additional therapeutic tools for patients who are experiencing different types of pain or discomfort.
“We adopt an adaptive admittance control algorithm to optimize force and position control, ensuring safety and comfort,” wrote Yuan Xu, Kui Huang, Weichao Guo and Leyi Du in their paper. “The paper analyzes key TCM techniques from kinematic and dynamic perspectives and designs robotic systems to reproduce these massage techniques.”
Salt, or more precisely the sodium it contains, is very much a “Goldilocks” nutrient. Low sodium levels cause a drop in blood volume, which can have serious, sometimes deadly, health consequences. Conversely, too much salt can lead to high blood pressure and cardiovascular disease.
In modern America, where most people consume a high-salt diet, almost no one is in danger of having too little salt. However, given the critical importance of sodium for body and brain functions, evolution has developed a powerful drive to consume salt in situations where there is a deficiency.
Understanding the brain circuitry that controls salt appetite has proved elusive, but now a new study by University of Iowa researchers has identified the first and, thus far, only neurons necessary for salt appetite.
