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UCLA Health researchers have identified a process that memories while reducing metabolic costs, even during sleep. This efficient memory is found in a brain region essential for learning and memory, which is also where Alzheimer’s disease originates.

The discovery is published in the journal Nature Communications.

Does this sound familiar: You go to the kitchen to fetch something, but when you get there, you forget what you wanted. This is your working memory failing. Working memory is defined as remembering some information for a short period while you go about doing other things. We use working memory virtually all the time. Alzheimer’s and dementia patients have working memory deficits and it also shows up in mild cognitive impairment (MCI). Hence, considerable effort has been devoted to understanding the mechanisms by which the vast networks of neurons in the brain create working memory.

Cells in the human body chat with each other all the time. One major way they communicate is by releasing tiny spheres called exosomes. These carry fats, proteins, and genetic material that help regulate everything from pregnancy and immune responses to heart health and kidney function.

Now, a new Columbia University study in Nature Nanotechnology demonstrated that these “nanobubbles” can deliver potent immunotherapy directly to tough-to-treat lung cancer tumors via inhalation.

“Exosomes work like text messages between cells, sending and receiving information,” said lead researcher Ke Cheng, PhD, professor of biomedical engineering at Columbia. “The significance of this study is that exosomes can bring mRNA-based treatment to lung cancer cells locally, unlike systemic chemotherapy that can have side effects throughout the body. And inhalation is totally noninvasive. You don’t need a nurse to use an IV needle to pierce your skin.”

Chinese scientists have developed a new type of lens that can be used for health care and augmented reality (AR). Based on radio frequency, the eye-tracking smart contact lenses don’t require battery or conventional silicon chips and are biocompatible and imperceptible.

Set to be used for human-machine interaction (HMI), the smart contact lenses rely on tracking eye movements. The lenses use methods like pupil center corneal reflection and electrooculography (EOG) to track eye movements.

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem that the WHO declared a pandemic. COVID-19 has resulted in a worldwide lockdown and threatened to topple the global economy. The mortality of COVID-19 is comparatively low compared with previous SARS outbreaks, but the rate of spread of the disease and its morbidity is alarming. This virus can be transmitted human-to-human through droplets and close contact, and people of all ages are susceptible to this virus. With the advancements in nanotechnology, their remarkable properties, including their ability to amplify signal, can be used for the development of nanobiosensors and nanoimaging techniques that can be used for early-stage detection along with other diagnostic tools.

Scientists have analyzed locks of Ludwig van Beethoven’s hair and found evidence of lead poisoning, which may have contributed to his chronic ailments and deafness. This discovery sheds new light on the famous composer’s health and adds to the ongoing debate about the cause of his death.

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Depression and cardiovascular disease (CVD) are serious concerns for public health. Approximately 280 million people worldwide have depression, while 620 million people have CVD.

It has been known since the 1990s that the two diseases are somehow related. For example, people with depression run a greater risk of CVD, while effective early treatment for depression cuts the risk of subsequently developing CVD by half. Conversely, people with CVD tend to have depression as well. For these reasons, the American Heart Association (AHA) advises to monitor teenagers with depression for CVD.

What wasn’t yet known is what causes this apparent relatedness between the two diseases. Part of the answer probably lies in lifestyle factors common in patients with depression and which increase the risk of CVD, such as smoking, alcohol abuse, lack of exercise, and a poor diet. But it’s also possible that both diseases might be related at a deeper level, through shared developmental pathways.

A study focusing on childhood maltreatment in Australia has uncovered its alarming impact, estimating it causes up to 40 percent of common, life-long mental health conditions.

The mental health conditions examined were anxiety, depression, harmful alcohol and drug use, self-harm, and suicide attempts. Childhood maltreatment is classified as physical, sexual, and emotional abuse, and emotional or physical neglect before the age of 18. Childhood maltreatment was found to account for 41 percent of suicide attempts in Australia, 35 percent for cases of self-harm, and 21 percent for depression.

The analysis, published in JAMA Psychiatry is the first study to provide estimates of the proportion of mental health conditions in Australia that arise from childhood maltreatment. The researchers said the results are a wake-up call for childhood abuse and neglect to be treated as a national public health priority.

Irina Conboy, Michael Conboy and Josh Mitteldorf discuss one of the central questions in aging research: is aging an active process of the body or is aging a passive process of damage accumulation? See the whole debate on our YouTube Channel: @HealesMovies Josh Mitteldorf, PhD, runs the blog “Aging Matters” (https://joshmitteldorf.scienceblog.com/) and is a consultant in mathematical modeling and creative data analysis. His research areas include evolutionary ecology, biology of aging, and the epidemiology of COVID-19. On the field of aging research, he has published two books,” Cracking The Aging Code”, co-written with Dorion Sagan (https://www.amazon.com/Cracking-Aging-Code-Science-Growing/d…atfound-20 and “Aging is a Group-Selected Adaptation” (https://drive.google.com/file/d/1bs0faQEV3T9cu-Eq079-e5bIGgMwNH08/view). Heales website (Healthy Life Extension Society): https://heales.org/ Subscribe to our newsletter: https://heales.org/newsletter/ Contact e-mail: [email protected] #science #aging #rejuvenation #biology #health #longevity #antiaging #debate #stemcells #programmedaging #entropy #cancer #conboy #conboys #mitteldorf Music: Closer To Your Dream by Keys of Moon | https://soundcloud.com/keysofmoon (CC BY 4.0)