Lifeboat Foundation

Only a matter of time til we can have nanobots clearing this out.

In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta — the neurotoxin believed to be at the root of Alzheimer’s disease (AD) — forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this devastating neurological disease.

Among his many contributions to research on AD, Rudolph Tanzi, PhD, vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer’s disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). When this protein is cut (or cleaved) by enzymes — first, beta secretase, followed by gamma secretase — the byproduct is amyloid beta (sometimes shortened to Abeta). Large deposits of amyloid beta are believed to cause neurological destruction that results in AD. Amyloid beta formed in the brain’s axons and nerve endings causes the worst damage in AD by impairing communication between nerve cells (or neurons) in the brain. Researchers around the world have worked intensely to find ways to block the formation of amyloid beta by preventing cleavage by beta secretase and gamma secretase. However, these approaches have been hampered by safety issues.

Continue reading “Alzheimer’s Mystery Solved: How Amyloid Beta Forms in Brain Nerve Cells” »

Mitochondrial disorders, nano-medicine drug delivery, and innovative therapeutic interventions — dr. volkmar weissig scd, phd — president, world mitochondria society — professor, midwestern university.

Dr. Volkmar Weissig, Sc. D., Ph.D. is a Tenured Full Professor of Pharmacology, Chair of the Department of Pharmaceutical Sciences, and Co-Director of the Nanomedicine Center of Excellence in Translational Cancer Research, at Midwestern University, Glendale, AZ, USA.

Continue reading “Dr Volkmar Weissig, ScD, PhD — President, World Mitochondria Society — Professor — Midwestern Univ” »

Ray Kurzweil — Singularitarian Immortalist, Director of Engineering at Google, famous inventor, author of How to Create a Mind http://GF2045.com/speakers/.

A world-class prolific inventor and leading futurist author, “the restless genius” (Wall Street Journal) points to 2045 for the technological singularity when A.I. will surpass human intelligence in his New York Times best seller The Singularity is Near, Amazon’s #1 book in science and philosophy.

Continue reading “Ray Kurzweil — Immortality by 2045” »

Quantum technology typically employs qubits (quantum bits) consisting of, for example, single electrons, photons or atoms. A group of TU Delft researchers has now demonstrated the ability to teleport an arbitrary qubit state from a single photon onto an optomechanical device—consisting of a mechanical structure comprising billions of atoms. Their breakthrough research, now published in Nature Photonics, enables real-world applications such as quantum internet repeater nodes while also allowing quantum mechanics itself to be studied in new ways.

Quantum optomechanics

The field of quantum optomechanics uses optical means to control mechanical motion in the quantum regime. The first quantum effects in microscale mechanical devices were demonstrated about ten years ago. Focused efforts have since resulted in entangled states between optomechanical devices as well as demonstrations of an optomechanical quantum memory. Now, the group of Simon Gröblacher, of the Kavli Institute of Nanoscience and the Department of Quantum Nanoscience at Delft University of Technology, in collaboration with researchers from the University of Campinas in Brazil, has shown the first successful teleportation of an arbitrary optical qubit state onto a micromechanical quantum memory.

The National Nanotechnology Initiative promised a lot. It has delivered more.

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The extracellular matrix (ECM) including three-dimensional (3D) network and bioelectricity can profoundly influence cell development, migration, and functional expression. In a new report now published on Science Advances, Tong Li and a research team in chemistry, nanotechnology, bioelectronics and advanced materials in China, developed an electromechanical coupling bio-nanogenerator abbreviated bio-NG inspired by biophysical cues of the extracellular matrix. The device contained highly discrete piezoelectric fibers to generate piezo potential of up to millivolts to provide in situ electrical stimulation for living cells.

Back-to-analogue computing model designed to mimic emergent properties of the brain.

GraphWear, a company pursuing needle-free approaches to glucose monitoring, has closed a $20.5 million Series B round. This Series B round is a vote of confidence by investors in GraphWear’s approach: to monitor key metrics in the body, like glucose, without breaking the skin at all.

GraphWear Technologies was founded in 2015 by Rajatesh Gudibande and Saurabh Radhakrishnan, who had both completed master’s degrees in nanotechnology at the University of Pennsylvania. Specifically, GraphWear is developing a skin-surface-level wearable made of graphene (more on this material later). The sensor is small, about the size of an Apple Watch — but the key piece of technology is actually housed on the bottom. It’s a thin slice of graphene that fits onto the back of the watch, or onto a sticker that can be worn on the abdomen.

This Series B round, says Gudibande, will be focused on helping the company build upon previous validation studies of the wearable, completing a pivotal trial and submitting for FDA clearance. The round was led by Mayfield, with participation from MissionBio Capital, Builders VC and VSC Ventures.

Nonlinearity induced by a single photon is desirable because it can drive power consumption of optical devices to their fundamental quantum limit, and is demonstrated here at room temperature.

The recent progress in nanotechnology1,2 and single-molecule spectroscopy3–5 paves the way for emergent cost-effective organic quantum optical technologies with potential applications in useful devices operating at ambient conditions. We harness a π-conjugated ladder-type polymer strongly coupled to a microcavity forming hybrid light–matter states, so-called exciton-polaritons, to create exciton-polariton condensates with quantum fluid properties. Obeying Bose statistics, exciton-polaritons exhibit an extreme nonlinearity when undergoing bosonic stimulation6, which we have managed to trigger at the single-photon level, thereby providing an efficient way for all-optical ultrafast control over the macroscopic condensate wavefunction. Here, we utilize stable excitons dressed with high-energy molecular vibrations, allowing for single-photon nonlinear operation at ambient conditions.