Lifeboat Foundation

Quantum computers have the potential to revolutionize our understanding of the world around us—and teach us how to manipulate it. The technology could enable the rapid design and development of life-saving drugs, simulate superconducting materials that would revolutionize technology and clean energy, and even offer insight into the underlying structure of space and time. Like the qubits that sit in superposition at the heart of quantum computers, the possibilities seem endless.

“Right now, you will find people who see quantum computing as a panacea,” says Susanne Yelin, a professor of physics in residence at Harvard’s Faculty of Arts and Sciences. “I am not one of them. But quantum computing could help us better understand fundamental physics, such as problems in condensed matter or particle physics. It could also advance quantum chemistry [which uses quantum physics to understand chemical systems]—and with it, better development of drugs and materials.”

At the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (Harvard Griffin GSAS), PhD physics students Maddie Cain, on whose dissertation committee Yelin sits, and Dolev Bluvstein are working to make the promise of quantum computing a reality. In the laboratory of Professor Mikhail Lukin, Cain and Bluvstein push the boundaries of science, advancing the prospects of transformative applications that could reshape our world.

In rainbow trout, classification of ionocytes based on the expressed transporters is still in progress. The Nhe3-positive ionocytes expressing basolateral Nka and Nkcc1 and apical Nhe3b have been found in both freshwater-and seawater-acclimated rainbow trout. Colocalization of an Rh glycoprotein (Rhcg1, ammonium transporter) and Nhe3b at the apical membrane was also observed, suggesting ammonia-dependent Na⁺ uptake by Nhe3-positive ionocytes (Hiroi and McCormick 2012). The Nhe3-negative ionocytes, which also lack Nkcc1, are observed mainly in freshwater (Katoh et al. 2008; Hiroi and McCormick 2012). Ncc2, the apical Cl⁻ pathway in tilapia type-II ionocytes, is thought to be absent in the gill of salmonids (Hiroi and McCormick 2012). The Nhe3-positive ionocytes showed basolateral Nka and Nkcc1 both in freshwater and seawater, suggesting that Nhe3-positive ionocytes are analogous to tilapia types-III and-IV and could be equipped with apical Cftr in seawater (Hiroi and McCormick 2012; Takei et al. 2014). However, localization of Cftr proteins by immunohistochemistry has not been successful in salmonids even with homologous antibodies (Takei et al. 2014). The mRNA of slc26a6 has been reported to be highly expressed in the gills of freshwater-acclimated rainbow trout (Boyle et al. 2015; Leguen et al. 2015) and it is very likely that this transporter is responsible for the uptake of Cl⁻ in freshwater, but detailed localization of this protein in the gills has not been elucidated. In short, the molecules responsible for the Cl⁻ transport across the apical membrane have not been identified in both freshwater-and seawater-acclimated rainbow trout.

Salmonids possess two cftr genes, cftr1 and cftr2 (Chen et al. 2001), and it has been reported that the expression level of both genes increases in the gill of chum salmon Oncorhynchus keta after the transfer to seawater during the juvenile stage (Wong et al. 2019). Expression of cftr1 in the gills increased also in rainbow trout after seawater transfer (Gerber et al. 2018). On the other hand, dietary salt loading reduced cftr2 expression in the gill of rainbow trout in freshwater (Kolosov and Kelly 2016). At this time, it is not clear which of these two molecules is mainly responsible for hypo-osmoregulatory Cl⁻ secretion in the gills of salmonids.

The objective of the present study is to examine molecules responsible for the active transport of Cl⁻ in gill ionocytes of rainbow trout. To achieve this goal, we conducted tissue distribution analyses on the expression of slc26a6, cftr1, and cftr2 in rainbow trout acclimated to freshwater or seawater. Time-course changes in the expression of these genes were also examined during seawater transfer. We localized these proteins in the gill filaments of rainbow trout acclimated to freshwater or seawater by whole-mount immunohistochemistry.

We are made out of functions, and those functions are made out of functions, all the way down.

Even bacteria—the simplest life forms surviving today—are a product of many subsequent evolutionary steps.

IX. Ecology

Continue reading “In the Beginning, There Was Computation” »

A new technology can extract lithium from brines at an estimated cost of under 40% that of today’s dominant extraction method, and at just a fourth of lithium’s current market price. The new technology would also be much more reliable and sustainable in its use of water, chemicals, and land than today’s technology, according to a study published in Matter by Stanford University researchers.

Global demand for lithium has surged in recent years, driven by the rise of electric vehicles and renewable energy storage. The dominant source of lithium extraction today relies on evaporating brines in huge ponds under the sun for a year or more, leaving behind a lithium-rich solution, after which heavy use of potentially toxic chemicals finishes the job. Water with a high concentration of salts, including lithium, occurs naturally in some lakes, hot springs, and aquifers, and as a byproduct of oil and natural gas operations and of seawater desalination.

Many scientists are searching for less expensive and more efficient, reliable, and environmentally friendly lithium extraction methods. These are generally direct lithium extraction that bypasses big evaporation ponds. The new study reports on the results of a new method using an approach known as “redox-couple electrodialysis,” or RCE, along with cost estimates.

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Can biology be explained entirely in terms of chemistry and then physics? If so, that’s “reductionism.” Or are there “emergent” properties at higher levels of the hierarchy of life that cannot be explained by properties at lower or more basic levels?

Continue reading “Michael Ruse — Philosophy of Reductionism & Emergence” »

The distribution of outermost shell electrons, known as valence electrons, of organic molecules was experimentally observed for the first time by a team led by Nagoya University in Japan. As the interactions between atoms are governed by the valence electrons, their findings shine light on the fundamental nature of chemical bonds, with implications for pharmacy and chemical engineering. The results were published in the Journal of the American Chemical Society.

The new research harnesses previously unknown features of this ancient viral DNA, creating a biological clock to track a person’s age from the DNA’s chemical changes.

And the researchers now believe that new antiretroviral therapies, similar to those used to fight the HIV virus and AIDS, might one day help reverse the signs of aging.

‘Our findings indicate that retroelement clocks capture previously undetected facets of biological aging,’ said study co-author Dr Michael Corley, an assistant professor of immunology at Weill Cornell Medicine in New York.

Engineers have designed a tiny battery, smaller than a grain of sand, to power microscopic robots for jobs such as drug delivery or locating leaks in gas pipelines.

A tiny battery designed by MIT engineers could enable the deployment of cell-sized, autonomous robots for drug delivery within in the human body, as well as other applications such as locating leaks in gas pipelines.

The new battery, which is 0.1 millimeters long and 0.002 millimeters thick — roughly the thickness of a human hair — can capture oxygen from air and use it to oxidize zinc, creating a current with a potential of up to 1 volt. That is enough to power a small circuit, sensor, or actuator, the researchers showed.

Continue reading “MIT engineers design tiny batteries for powering cell-sized robots” »

A view into how nanoscale building blocks can rearrange into different organized structures on command is now possible with an approach that combines an electron microscope, a small sample holder with microscopic channels, and computer simulations, according to a new study by researchers at the University of Michigan and Indiana University.

The approach could eventually enable smart materials and coatings that can switch between different optical, mechanical and electronic properties.

Continue reading “Morphable materials: Researchers coax nanoparticles to reconfigure themselves” »