Lifeboat Foundation

This book argues for sentience at the level of cell or even in pre-cell form of matter.

Chapters: 0:00 Colin Wright Highlights 0:48 Colin Wright: A Horrible Person, A Transphobe? 3:43 Did This Piss Colin Off? 6:03 Humans Will Always Do Magical Thinking 8:32 If We Stand Up Together… 9:48 The Fundamental Misunderstanding / Fish 12:48 What Activists Get Wrong (Secondary Characteristics) 15:48 The ‘True’ Hermaphrodite 17:48 Is There A Male or Female Brain? 21:48 Judith Butler’s Contradiction 24:48 Individual Liberty 27:48 Young Girls & Older Men 30:48 Cross-Dressers Getting Aroused 34:18 How Sex Is Determined In Nature 37:38 Why Do Men Have Nipples? 38:58 Why Don’t Testicles Have Rib Cages? 40:18 Creationism vs Evolution (Joe Rogan) 44:18 Alex Jones & Gay Frogs 45:08 What Does ‘Theory’ of Evolution Mean? 48:08 Other Competing Theories? 51:28 Faith vs Science 53:48 Danger of Reality Denial 57:43 A Heretic Colin Admires.

It is estimated that living neurons can use over 1 million times less energy than the current digital processors we use.

A startup in Switzerland has built a unique computer processor made from 16 tiny brains made from human tissue, basically a living computer.

Advanced glycation end products (AGEs) accumulate in the brain, leading to neurodegenerative conditions such as Alzheimer’s disease (AD). The pathophysiology of AD is influenced by receptors for AGEs and toll-like receptor 4 (TLR4). Protein glycation results in irreversible AGEs through a complicated series of reactions involving the formation of Schiff’s base, the Amadori reaction, followed by the Maillard reaction, which causes abnormal brain glucose metabolism, oxidative stress, malfunctioning mitochondria, plaque deposition, and neuronal death. Amyloid plaque and other stimuli activate macrophages, which are crucial immune cells in AD development, triggering the production of inflammatory molecules and contributing to the disease’s pathogenesis. The risk of AD is doubled by risk factors for atherosclerosis, dementia, advanced age, and type 2 diabetic mellitus (DM). As individuals age, the prevalence of neurological illnesses such as AD increases due to a decrease in glyoxalase levels and an increase in AGE accumulation. Insulin’s role in proteostasis influences hallmarks of AD-like tau phosphorylation and amyloid β peptide clearance, affecting lipid metabolism, inflammation, vasoreactivity, and vascular function. The high-mobility group box 1 (HMGB1) protein, a key initiator and activator of a neuroinflammatory response, has been linked to the development of neurodegenerative diseases such as AD. The TLR4 inhibitor was found to improve memory and learning impairment and decrease Aβ build-up. Therapeutic research into anti-glycation agents, receptor for advanced glycation end products (RAGE) inhibitors, and AGE breakers offers hope for intervention strategies. Dietary and lifestyle modifications can also slow AD progression. Newer therapeutic approaches targeting AGE-related pathways are needed.

A clip of Daniel Dennett discussing consciousness and what he famously calls the Cartesian Theater. This comes from a 2015 documentary on Dennett.

#Philosophy #Dennett #Consciousness

“For the Love of Sophia!” philosophy podcast available on Spotify, Apple Podcasts, and Soundcloud. Today, we’ll be discussing Daniel Dennett’s “Explaining the…

Science: Friends I want to propose a way to beginning the Scientific Research about Ressurection:

My idea is simple.

Join my mailing list https://briankeating.com/list to win a real 4 billion year old meteorite! All.edu emails in the USA 🇺🇸 will WIN!

Previous guest and friend of the show, Sir Roger Penrose, argues that human consciousness is not algorithmic and, therefore, cannot be modeled by Turing machines. In fact, he believes in a quantum mechanical understanding of human consciousness. However, as with any issue related to human consciousness, many disagree with him. One of his opponents is Daniel Dennett, with whom I recently had the pleasure of talking. Tune in to find out why Dennett thinks Penrose is wrong!

Continue reading “Dan Dennett: Sir Roger Penrose Is WRONG About Human Consciousness!” »

Together with collaborators in Michigan’s Neural Circuits and Memory Lab led by Diba, Rice neuroscientist Caleb Kemere has been studying the process by which specialized neurons produce a representation of the world after a new experience.

Some dreams may, in fact, predict the future: New research has found that during sleep, some neurons not only replay the recent past but also anticipate future experience.