An analysis and improvement of the spectral properties of nitrogen-vacancy defects in diamond nanostructures paves the way for efficient entanglement generation necessary for many quantum information applications.
c Department of Chemical Biology, Xiamen University, Xiamen, 361,005, China.
The concept of xeno-nucleic acids (XNAs) was first proposed in 2009 in a theoretical paper, referring to additional types of nucleic acids, whose sugar moieties would differ from those in DNA and RNA. However, with the rising popularity of XNAs, the definition of XNAs has been extended to unnatural nucleic acids with chemically modified sugar, nucleobase, or phosphate moieties that are distinct from those found in DNA and RNA. The discovery and engineering of both polymerases and reverse transcriptases to synthesize, replicate and evolve a diverse range of XNAs has attracted significant attention and has enabled the discovery of XNA ligands (aptamers) and XNA catalysts (XNAzymes) as well as the synthesis of XNA nanostructures with potential as novel therapeutics. The field of XNAs continues to grow rapidly towards realizing the potential of XNAs in biotechnology and molecular medicine. This themed issue unites a collection of articles attesting to the rapid progress in the field.
One of the key advantages of XNAs is their generally enhanced resistance to nuclease degradation. This biostability, the affinity and specificity towards a target, and the general lack of immunogenicity of modified nucleic acids are critical for their potential application as therapeutics. Modified sugar moieties such as 2′-modified analogs, conformationally locked analogs, and threose-replaced analogs in particular contribute to the increased biological stability of XNAs against enzymatic degradation. Replacing the phosphodiester linkages with charge-neutral backbones including peptide-like backbones and triazole-linked backbones offers further opportunities to tune the stability, conformation and physicochemical properties of XNAs and enhance the affinity to their targets.
Researchers have designed a 3D-patterned, graphene.
Graphene is an allotrope of carbon in the form of a single layer of atoms in a two-dimensional hexagonal lattice in which one atom forms each vertex. It is the basic structural element of other allotropes of carbon, including graphite, charcoal, carbon nanotubes, and fullerenes. In proportion to its thickness, it is about 100 times stronger than the strongest steel.
In the pearly light of the pocket nucleo-bulb…’ — Isaac Asimov, 1951.
Cheap Paper-Based Sensors Let You Snoop For Pesticides ‘…the unobtrusive inspections with tiny remote-cast snoopers.’ — Frank Herbert, 1965.
Modern App Provides Video Technology From Bradbury’s ‘Fahrenheit 451’ ‘A special spot-wavex scrambler also caused his televised image, in the area immediately about his lips, to mouth the vowels and consonants beautifully.’ — Ray Bradbury, 1953.
Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.
With further development, these particles could offer an inhalable treatment for cystic fibrosis and other diseases of the lung, the researchers say.
“This is the first demonstration of highly efficient delivery of RNA to the lungs in mice. We are hopeful that it can be used to treat or repair a range of genetic diseases, including cystic fibrosis,” says Daniel Anderson, a professor in MIT’s Department of Chemical Engineering and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES).
“You won’t live forever” is a catchphrase which has often been touted and has so far remained the proven truth of life — of humans and almost every other living being on planet earth. But soon, this catchphrase may well become the truth of the past, as humanity steps forward to attain immortality.
A former Google scientist has made a prediction, which if proven right, may redefine human civilisation as we know it. Ray Kurzweil, whose over 85 per cent of 147 predictions have been proven right, has predicted that humans will become immortal by 2029.
The revelation came when the 75-year-old computer scientist dwelled upon genetics, nanotechnology, robotics and more in a YouTube video posted by channel Adagio.
Nanomedicine uses nanomaterials [e.g., carbon nanotubes (CNTs), nanoparticles, and nanodiscs] or organic nanostructures (e.g., DNA origami and liposomes) for drug delivery (8–10), medical imaging (11–14), and tissue regeneration (15). Nanomaterials offer therapeutic efficacy through their tissue permeation, interaction with an external energy source, and capability to be combined with other therapeutic modalities (16, 17). Because we recently demonstrated that GBM cells are mechanosensitive (18), we set to use nanomaterials to develop a nanoscale mechanical approach to treat GBM. Mechanical perturbation has been investigated as an approach to target cancer cells. For example, magnetic field–actuated nanomaterials compromise the integrity of plasma membrane, leading to the death of in vitro–cultured GBM cells (19) and breast cancer cells (20). GBM cells, which were preincubated with magnetic nanoparticles, were implanted into mice to generate xenograft tumors. A rotating magnetic field, which was then applied to these magnetic particles–harboring tumors, suppressed GBM growth (21). Similarly, magnetic field mobilization of mitochondria-targeting magnetic nanoparticle chains demonstrated efficacy in inhibiting GBM growth in mice (22). While these studies showed that magnetic field–controlled nanomaterials can be used in cancer treatment, the utility of magnetic nanomaterials in treating chemoresistant tumors, the root cause of tumor relapse and patient death, remains unexplored.
GBM displays an extreme level of heterogeneity at genomic, epigenetic, biochemical signaling, and cellular composition levels (23). The heterogeneous nature of GBM confers treatment resilience to tumors and leads to a unifying therapy resistance mechanism; i.e., suppressing selected proteins or biochemical pathways provides a fertile ground for alternative signaling mechanisms, which are not targeted by the given therapy, to fuel GBM growth (24). In other words, the “whack-a-mole” approach failed to benefit patients with GBM for decades. For this reason, we hypothesized that nanomaterial-based mechanical treatment of cancer cells, rather than specific targeting of signaling pathways, can overcome the therapy resistance of this biologically plastic disease. To this end, we engineered a mechanical nanosurgery approach using magnetic CNTs (mCNTs; nanotubes with carbon surface and a cavity filled with iron particles) based on the following reasons.
Cambridge researchers have discovered a new topological phase in a two-dimensional system, which could be used as a new platform for exploring topological physics in nanoscale devices.
Two-dimensional materials such as graphene have served as a playground for the experimental discovery and theoretical understanding of a wide range of phenomena in physics and materials science. Beyond graphene, there are a large number 2D materials, all with different physical properties. This is promising for potential applications in nanotechnology, where a wide range of functionality can be achieved in devices by using different 2D materials or stacking combinations of different layers.
It was recently discovered that in materials such as hexagonal boron nitride (hBN), which are less symmetric than graphene, ferroelectricity occurs when one layer slides over the other and breaks a symmetry. Ferroelectricity is the switching of a material’s electric dipole moment with an electric field, which is a useful property for information processing and memory storage.
One can only hope.
A former Google engineer has just predicted that humans will achieve immortality in eight years, something more than likely considering that 86% of his 147 predictions have been correct.
Ray Kurzweil visited the YouTube channel Adagio, in a discussion on the expansion of genetics, nanotechnology and robotics, which he believes will lead to age-reversing ‘nanobots’.
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In this educational film scientists and engineers explain the construction of materials beginning at an atomic scale.
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