Lifeboat Foundation

I, for one, still dream of flourishing in the future through advances in science and technology, but hopefully one that addresses societal inequities, retains the richness and diversity of our natural systems and indigenous cultures, rather than the somewhat simple and sterile futures depicted by many science fiction writers and futurists. Timothy Leary liked to remind us to remember our hippie roots, with their celebration of diversity and nature, and I hear him calling us again.

What used to be the province of acid-tripping tie-dye wearers has been co-opted by Silicon Valley—and we must be responsible about how we wield this new reality.

The secret to longevity may lie in the microbiome and the gut, according to researchers from McGill University, Canada.

It is already known that the bacteria living in our intestinal tract could have an influence on how well we age. Building on this knowledge, McGill University scientists fed fruit flies with a combination of probiotics and a herbal supplement called Triphala. These experiments were able to prolong the insects’ longevity by 65% and protect them against chronic diseases associated with aging.

Aged population is increasing worldwide due to the aging process that is inevitable. Accordingly, longevity and healthy aging have been spotlighted to promote social contribution of aged population. Many studies in the past few decades have reported the process of aging and longevity, emphasizing the importance of maintaining genomic stability in exceptionally long-lived population. Underlying reason of longevity remains unclear due to its complexity involving multiple factors. With advances in sequencing technology and human genome-associated approaches, studies based on population-based genomic studies are increasing. In this review, we summarize recent longevity and healthy aging studies of human population focusing on DNA repair as a major factor in maintaining genome integrity. To keep pace with recent growth in genomic research, aging- and longevity-associated genomic databases are also briefly introduced. To suggest novel approaches to investigate longevity-associated genetic variants related to DNA repair using genomic databases, gene set analysis was conducted, focusing on DNA repair- and longevity-associated genes. Their biological networks were additionally analyzed to grasp major factors containing genetic variants of human longevity and healthy aging in DNA repair mechanisms. In summary, this review emphasizes DNA repair activity in human longevity and suggests approach to conduct DNA repair-associated genomic study on human healthy aging.

Aging is an inevitable process in human life. Many countries are rapidly transitioning to an aging society due to increasing life expectancy and advanced medical supports [1–3]. Over the last few decades, the advent of aging society is considered a crucial issue that may cause future decline in productivity of community [1, 4]. Many researchers have recently warned that urban environmental pollutants can cause physiological weakness and increase the risk of premature aging or chronic diseases in the elderly population [5–9]. Thus, interest in antiaging and healthy longevity is constantly increasing. “Active aging” or “successful aging” has been spotlighted as a strategy to promote social contribution of the elderly [10]. The definition of successful aging remains controversial.

Some thoughts on rejuvenation, the world it’ll leave behind, and the world it may create.

Human beings like feeling safe. The unknown always presents a certain percentage of risk, though probably much less so today than in the past. Back in the days of our primitive ancestors, leaving an old way for a new one might more easily have led to death than it can today, so it’s no surprise that we have evolved to be suspicious of novelties coming our way; this might well be one reason why enacting change is not very easy for our species.

Sometimes, what we already have is not the best arrangement; other options might prove better, though they do come with some uncertainty. Will the new option really bring benefits? Will it be worth the cons of discarding the old way of doing things? How much work will it take to move from the old way to the new one? Will the new way only bring benefits, or will it have challenges and problems as well?

Continue reading “Thoughts on the world behind and the world ahead” »

Sought after guest speaker, Aubrey de Grey, has appeared on numerous popular programs including CBS 60 Minutes, BBC, TED and The Colbert Report to name just a few. Today, he joins The Future Tech Podcast, to share his vision on how we can improve the aging process through enhancing the human body’s capability of rejuvenation through cell immortality and pluripotency to human aging and age-related disease.

The. Vice President of New Technology and Discovery at AgeX Therapeutics, Aubrey de Grey, Ph.D., is also the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs, and funds research devoted to battling the progression of aging.

In this fascinating discussion, Aubrey explains some of the obstacles that need to be overcome, including issues involving age-related tissue damage and stem cell decline which contribute to accelerating the aging process. He also discusses what AgeX is doing in stem cell research and in regenerative medicine that will improve not only the longevity of life, but also the quality and health of individuals throughout the aging process. He also touches on what he sees could be the future in the science of aging and treatments being worked on by the rejuvenation research community.

Continue reading “Aubrey De Grey – PhD. and Vice President of New Technology Discovery at Agex Therapeutics – The Age Old Question of How Can We Combat Aging?” »

New research on brain ageing and mitochondria from Salk Institute.

Thanks to a new technique, researchers from the Salk Institute’s Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases in the first place [1].

In particular, Salk scientists observed that induced neurons (iNs) obtained from fibroblasts of older individuals had dysfunctional mitochondria and therefore decreased energy levels compared to younger neurons. Out-of-shape mitochondria have previously been implicated in degenerative brain diseases, such as Alzheimer’s and Parkinson’s, and this finding might help reveal more about the connection between these diseases and this particular hallmark of aging.

Continue reading “Mitochondrial dysfunction in aged brain cells” »

http://www.thepathmag.com/can-you-actually-hack-your-dna-to-slow-down-aging/

Many technologies / interventions progressing down the development pathways in the coming years — but there are a lot of free, common sense adjustments you can make today:

https://player.fm/series/healthy-relationship-talk-radio/cel…1-2018

http://www.blogtalkradio.com/entrepreneursempower/2018/06/03…ira-pastor