Lifeboat Foundation

Westworld’s first season was largely focused on the abuse of artificial life, given that the park hosts’ purpose almost exclusively revolved around sex, violence, and suffering. The freedom Dolores and her ilk were fighting for was simple consciousness—a right to their own memories and self-awareness. In just the first four episodes, Westworld’s second season has exploded that basic quest into all kinds of fascinating directions, but “The Riddle of the Sphinx” was the first to really grapple with one of the most obvious questions in AI, which is: Isn’t artificial intelligence the key to immortality?

Three Atlantic staffers discuss “The Riddle of the Sphinx,” the fourth episode of Season 2.

The Astana Global Challenge Summit 2018 will host a series of panels and talks on longevity and rejuvenation.

As it has every year since 2008, the Astana Economic Forum (AEF) is about to take place in Astana, Kazakhstan. AEF, now also known as the Global Challenges Summit (GCS), is an international and regional non-profit platform for public discourse on topics such as economics, globalization, security, global risks, energy efficiency, innovation, and, more generally, matters concerning the future of our world and society. It was jointly created by the Eurasian Economic Club of Scientists Association and the Kazakhstan government back in 2008, and over the years, it has hosted innumerable talks and presentations by scientists, economists, world leaders, entrepreneurs, Nobel laureates, and other key people.

In our rapidly changing world, where we sometimes struggle to keep up the pace with progress, initiatives like this are greatly needed and welcome. In order to address the global issues we will face in the coming decades, cooperation, dialogue, information sharing, and networking will be pivotal, and events like the GCS are instrumental in achieving success. The themes of the 2018 event, which will be held on May 17–19, will include global strategy, sustainability, the future of money, clean energy, a unified economy, and many others. Around 500 speakers from all over the world will be on stage to discuss these important topics, sharing visions and insights to build a brighter and safer future together.

https://www.youtube.com/watch?v=qNSxkxyVptw

A new critical story on #transhumanism out in the National Review:

Its promise of a kind of immortality is an ersatz version of Christian hope for a resurrection in a glorified body.

An interview on rejuvenation science, advocacy, and more with Reason from the blog Fight Aging!.

Most people interested in rejuvenation and life extension are familiar with Fight Aging!, one of the very first rejuvenation advocacy blogs dating back all the way to the early 2000s; if you’re one of them, then you certainly are familiar with Reason, the man behind FA!.

Over the years, Reason has been a patient yet relentless advocate, acting not only as an information provider for the public but also helping out innumerable organizations and companies in the field of rejuvenation biotechnology in financial and other ways. Back in the day when SRF didn’t exist yet, Reason was a volunteer for Methuselah Foundation; eventually, he helped fund companies such as Oisìn Biotechnologies, CellAge, and LysoCLEAR; and, earlier this month, Reason and Bill Cherman co-founded Repair Biotechnologies, a company focused on gene therapy for rejuvenation, as announced on FA!.

Continue reading “Reason – Fight Aging! blog and Repair Biotechnologies” »

DALLAS – March 29, 2018 – Researchers from UT Southwestern’s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine’s Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called “anti-aging” protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. The investigation was performed in collaboration with scientists from New York University School of Medicine and Wenzhou Medical University in China.

Studies at UTSW two decades ago by Dr. Makoto Kuro-o, Professor of Pathology, demonstrated that mice lacking either a-Klotho or the hormone FGF23 suffered from premature and multiple organ failure as well as other conditions, including early onset cardiovascular disease, cancer, and cognitive decline. Because defects in a-Klotho lead to symptoms seen in aging, researchers inferred that a-Klotho suppresses aging, leading to great interest in how the a-Klotho protein might work together with the hormone FGF23 to fulfill their roles.

A-Klotho can exist on the surface of a cell or can be released from the cell and circulate in body fluids, including the blood, as soluble a-Klotho. The cell-attached form and the circulating form of a-Klotho were previously and universally believed to serve completely different functions.

Continue reading “Anti-aging protein alpha Klotho’s molecular structure revealed” »

And inflammation is one of the three primary ageing processes.

Scientists have discovered a new metabolic process in the body that can switch off inflammation. They have discovered that ‘itaconate’—a molecule derived from glucose—acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases including arthritis, inflammatory bowel disease and heart disease.

The scientists, working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin, hope their discovery will have relevance for inflammatory and infectious diseases—and that their findings may also help to develop much-needed new drugs to treat people living with these conditions.

Professor of Biochemistry at Trinity, Luke O’Neill, was, along with Dr. Mike Murphy of the University of Cambridge, the joint leader of the work just published in leading international journal Nature. The discoveries were made using both human cells and mice as a model organism.

Continue reading “Scientists discover promising off-switch for inflammation” »

The researchers found that when taking the supplement, dilation of subjects’ arteries improved by 42 percent, making their blood vessels, at least by that measure, look like those of someone 15 to 20 years younger.

Excess reactive oxygen species production by mitochondria is a key mechanism of age-related vascular dysfunction. Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. Here, we sought to translate our preclinical findings to humans and determine the safety and efficacy of MitoQ. Twenty healthy older adults (60–79 years) with impaired endothelial function (brachial artery flow–mediated dilation 6%) underwent 6 weeks of oral supplementation with MitoQ (20 mg/d) or placebo in a randomized, placebo-controlled, double-blind, crossover design study.

As humans, we are defined by, among other things, our desire to transcend our humanity. Mythology, religion, fiction and science offer different versions of this dream. Transhumanism – a social movement predicated on the belief that we can and should leave behind our biological condition by merging with technology – is a kind of feverish amalgamation of all four. Though it’s oriented toward the future, and is fuelled by excitable speculation about the implications of the latest science and technology, its roots can be glimpsed in ancient stories like that of the Sumerian king Gilgamesh and his quest for immortality.

Will humans ever conquer mortality by merging with technology? The 2018 Wellcome prize winner shares his favourite books on transhumanism, from a cyborg manifesto to a Don DeLillo novel.

Mark O’Connell

Continue reading “Mark O’Connell: five books to understand transhumanism” »