Lifeboat Foundation

What exactly is Obesity?

Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it is an essential actor in vital bodily processes like the immune response, the regulation of insulin sensitivity, and maintenance of body temperature. In a review published in the journal Cell on February 3rd, 2022, researchers argue that the negative health effects of obesity stem not simply from an excess of fat but from the decline in its ability to respond to changes, or in other words, its plasticity.

The makeup and functioning of this tissue changes in response to weight fluctuations and aging. As fat declines in plasticity due to aging and obesity, it loses its ability to respond to bodily cues. In the current model of this phenomenon, the rapid growth of adipose tissue outpaces its blood supply, depriving the fat cells of oxygen and causing the accumulation of cells that no longer divide. This leads to insulin resistance, inflammation, and cell death accompanied by the uncontrolled spill of lipids from these cells.

Continue reading “New Research Finds That With Obesity, the Problem Isn’t an Excess of Fat but Its Loss of Function” »

New South Wales has again received an overwhelming response from aspiring developers of wind, solar and storage projects, with more than 34GW of proposals for the South-West Renewable Energy Zone, more than 10 times its likely capacity.

The state government, through its newly formed Energy Corporation of NSW, ran a registration of interest process in October and November for the south-west region, one of at least five REZs planned to help replace the ageing coal fleet over the coming decade.

“There were 49 registrations totalling over 34 gigawatts from potential generation and storage projects – thirteen times the intended capacity for the South-West REZ, which will be no less than 2.5 gigawatts,” James Hay, the CEO of Energy Corp, said in a statement on Friday.

Excerpt taken from a conversation held between Peter Diamandis and Mark Hyman.

In the description of the video is the link of the original video with the entire conversation.

Continue reading “Peter Diamandis: never getting old is coming (clip from a talk w/ Mark Hyman) | S/T en Español” »

The so-called ‘longevity sirtuin’ Sirt6 shows both lifespan and healthspan benefits and a new paper digs deeper into just why that is.

Summary: A breakdown in regulatory mechanisms causes iron to build up in the brain during aging, increasing oxidative stress and increasing the risk of age-related cognitive decline, a new study reports.

Source: Northwestern University.

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

Summary: Participating in high levels of physical activities, such as swimming or a game of tennis, once a week helps stave off chronic musculoskeletal pain.

Source: University of Portsmouth.

Those hoping to avoid one of the worst side effects of aging—bone, joint and muscle pain that doesn’t go away—might need to exercise a lot harder and more often than previously believed.

The Neuro-Network.

𝐇𝐨𝐰 ‘𝐃𝐨𝐫𝐦𝐚𝐧𝐭’ 𝐂𝐞𝐥𝐥𝐬 𝐈𝐧 𝐓𝐡𝐞 𝐀𝐠𝐢𝐧𝐠 𝐁𝐫𝐚𝐢𝐧 𝐂𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐞 𝐓𝐨 𝐂𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐃𝐞𝐜𝐥𝐢𝐧𝐞

𝘾𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 𝙙𝙚𝙘𝙡𝙞𝙣𝙚 𝙖𝙣𝙙 𝙛𝙤𝙧𝙜𝙚𝙩𝙩𝙞𝙣𝙜 𝙩𝙝𝙞𝙣𝙜𝙨 𝙖𝙨 𝙬𝙚 𝙜𝙚𝙩 𝙤𝙡𝙙𝙚𝙧 𝙞𝙨 𝙖𝙡𝙢𝙤𝙨𝙩 𝙖 𝙧𝙞𝙜𝙝𝙩 𝙤𝙛 𝙥𝙖𝙨𝙨𝙖𝙜𝙚. 𝘼𝙡𝙡… See more.

Continue reading “How ‘Dormant’ Cells In The Aging Brain Contribute To Cognitive Decline” »

Accelerating Research To Prevent & Cure Disease — Dr. Kevin Perrott, Ph.D., Founder & CEO, OpenCures; Co-Founder & Treasurer, SENS Research Foundation

Dr. Kevin Perrott, Ph.D. is Founder and CEO, OpenCures (https://opencures.org/), Adjunct Professor, University of Alberta, Co-Founder and Advisor, Oisin Biotechnologies, President, of Global Healthspan Policy Institute, and Co-Founder and Treasurer, SENS Research Foundation.

Continue reading “Dr Kevin Perrott, PhD — Founder & CEO — OpenCures — Accelerating Research To Prevent & Cure Disease” »

Cam & Dowel Jig is a collection of preset jigs and various tools that are designed to help guide users through designing and constructing their own bespoke furniture.

If you didn’t pick up woodworking as a hobby during the quarantine, chances are you at least tried. In a perfect world, we’d have the know-how to pick up some tools, some pieces of wood, and design our living rooms with our own collection of bespoke furniture. Alas, this is no perfect world so we’ll need some shortcuts. Luckily, David Needham of Kingfisher Design Studio has us covered with an intuitive tool kit designed to streamline bespoke, DIY furniture-building projects.