Lifeboat Foundation

Pumping iron, weight-lifting, strength training—call it what you want, but it is key to living longer, according to Dr. Gabrielle Lyon.

Retro Biosciences’ mysterious backer has finally been revealed!

In 2021 the longevity industry received one of its largest investments to date, with a $180m investment being made into the pharmaceutical start known as Retro Biosciences, or Retro Bio for short. Not only was this investment cause for celebration within the field of regenerative medicine, but it also came with a tantalising mystery, as the backer, or indeed backer, did not make themselves publicly known. It was assumed that due to the secrecy involved, it was likely that this investment had come from a small number of individuals, potentially just a single backer. This mystery backer, combined with the notable capital investment, led to much media attention at the time, and has since garnered a significant amount of interest in Retro Bio from both the general public and future potential financial backers. That was until last week, when the mystery backer finally decided that now was the right time to reveal their identity to the general public.

In an interview with MIT Technology review, American entrepreneur Sam Altman revealed that he was the sole backer for the pharmaceutical start-up, who single handily provided the entire $180m investment. Sam Altman, who primarily made his fortune in the tech industry (specifically through social media companies such as Loopt) has become somewhat of an angel investor for a slew of world changing, innovative companies which are involved in everything from artificial intelligence to nuclear energy. It is hoped that this significant single investment marks the beginning of a longevity tech boom, similar to what was seen during the dot-com boom (but hopefully without the disastrous ending).

Opening comment which is repeated later: He is 50, but was biologically 60, until he changed his lifestyle and diet, and now he is 31. OMG does that mean we can already rejuvenate to a youthful state? Well no. These clocks measure how healthy you are, and yes if you copied David’s lifestyle you’ll get more years…or more accurately, healthy years. Perhaps David would have made it to 80, but now he’ll make it to 100 and be active for most of it. But that is not true rejuvenation. For that he mentions reprogramming near the end of the vid and the fact they are working on whole body rejuvenation with the success they had in the eyes of mice.

Are you tired of feeling old and worn out? Do you want to look and feel younger without resorting to expensive treatments or surgeries? In this video, Dr. David Sinclair shares his expert tips on how to slow and reverse aging using simple, everyday practices like intermittent fasting, supplements, a healthy lifestyle, and proper diet. With over 20 years of experience studying longevity, Dr. Sinclair is a leading authority on the science of aging.#intermittentfasting #supplements #longevity.

Continue reading “Harvard Professor Reveals 4 EASY Ways to Slow and Reverse Aging | Dr. David Sinclair” »

Insider rounded up 15 of the world’s wealthiest entrepreneurs searching for a solution to the predicament of mortality.

University of Virginia scientists have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time.

The new findings come from UVA researcher Eyleen Jorgelina O’Rourke, Ph.D., and her team, who are seeking to identify the mechanisms driving healthy aging and longevity. Their new work suggests a potential way to do so by reducing glycerol and glyceraldehyde’s health-draining effects.

“The discovery was unexpected. We went after a very well-supported hypothesis that the secret to longevity was the activation of a cell-rejuvenating process named autophagy and ended up finding an unrecognized mechanism of health and lifespan extension,” said O’Rourke, of UVA’s Department of Biology and the UVA School of Medicine’s Department of Cell Biology.

Recently is has become known that one should not take Metformin unless you have diabetes. But a combo test of Rapamycin and Metformin showed each removed each others side effects. So here we have another combo test showing the effect on stem cells in the gut.

In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1].

Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various cancers, including colorectal cancer. Therefore, it is necessary to develop therapeutic approaches to rejuvenate the aging intestine.

Continue reading “Metformin and Rapamycin Rejuvenate Stem Cells in Mice” »

A quick introduction to Yamanaka factors!

The quest for longevity has always been with us. Ever since the ancient kings of old we have been trying everything we can think of in order to stave off death and disease, with most of our efforts unfortunately baring little fruit. However, as it turns out, the power to reverse the aging process has been nestled within us this whole time. Not in the metaphorical sense, but rather in the quite literal sense. For you see, we have been reversing the aging process every single time we have reproduced.

Have you ever wondered how it is that regardless of how old the parents of a child are, the child is never born ‘pre-aged?’. This seems like a ridiculous question, but if the genetic material that came from the parents (especially from the father) has already undergone the aging process, then how is it that ‘genetic aging’ is not passed onto the child? If such a process were to occur, then it would obviously spell doom for our entire species, as we would eventually accumulate age with each subsequent generation and we would very quickly perish. Yet, this obviously does not happen. So the question was asked, why is this?

Summary: As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease.

Source: TCD

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on aging processes in the brain. By linking the increased presence of specialised immune cells to conditions such as Alzheimer’s disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related neurological diseases.

Reverse the aging process and live decades longer? Transfer your brain onto a database and achieve digital immortality? Humans one day may have such options.