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Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development.

Chemistry experts from Newcastle and Durham universities, working in collaboration with SPT Labtech, have grown the small crystals from nanoscale encapsulated droplets. Their innovative method, involving the use of inert oils to control evaporative solvent loss, has the potential to enhance the drug development pipeline.

Whilst crystallization of organic soluble molecules is a technique used by scientists all over the world, the ability to do so with such small quantities of analyte is ground-breaking.

A new door to the quantum world has been opened: When an atom absorbs or releases energy via the quantum leap of an electron, it becomes heavier or lighter. This can be explained by Einstein’s theory of relativity (E = mc²). However, the effect is minuscule for a single atom. Nevertheless, the team of Klaus Blaum and Sergey Eliseev at the Max Planck Institute for Nuclear Physics has successfully measured this infinitesimal change in the mass of individual atoms for the first time. In order to achieve this, they used the ultra-precise Pentatrap atomic balance at the Institute in Heidelberg. The team discovered a previously unobserved quantum state in rhenium, which could be interesting for future atomic clocks. Above all, this extremely sensitive atomic balance enables a better understanding of the complex quantum world of heavy atoms.

Astonishing, but true: If you wind a mechanical watch, it becomes heavier. The same thing happens when you charge your smartphone. This can be explained by the equivalence of energy (E) and mass (m), which Einstein expressed in the most famous formula in physics: E = mc² (c: speed of light in vacuum). However, this effect is so small that it completely eludes our everyday experience. A conventional balance would not be able to detect it.

But at the Max Planck Institute for Nuclear Physics in Heidelberg, there is a balance that can: Pentatrap. It can measure the minuscule change in mass of a single atom when an electron absorbs or releases energy via a quantum jump, thus opening a new world for precision physics. Such quantum jumps in the electron shells of atoms shape our world—whether in life-giving photosynthesis and general chemical reactions or in the creation of colour and our vision.

Developing an ideal wound dressing that meets the multiple demands of safe and practical, good biocompatibility, superior mechanical property and excellent antibacterial activity is highly desirable for wound healing. Bacterial cellulose (BC) is one of such promising class of biopolymers since it can control wound exudates and can provide moist environment to a wound resulting in better wound healing. However, the lack of antibacterial activity has limited its application.

We prepared a flexible dressing based on a bacterial cellulose membrane and then modified it by chemical crosslinking to prepare in situ synthesis of nZnO/BCM via a facile and eco-friendly approach. Scanning electron microscopy (SEM) results indicated that nZnO/BCM membranes were characterized by an ideal porous structure (pore size: 30~ 90 μm), forming a unique string-beaded morphology. The average water vapor transmission of nZnO/BCM was 2856.60 g/m²/day, which improved the moist environment of nZnO/BCM. ATR-FITR further confirmed the stepwise deposition of nano-zinc oxide. Tensile testing indicated that our nanocomposites were flexible, comfortable and resilient. Bacterial suspension assay and plate counting methods demonstrated that 5wt. % nZnO/BCM possessed excellent antibacterial activity against S.aureus and E. coli, while MTT assay demonstrated that they had no measurable cytotoxicity toward mammalian cells.

Recent events such as the COVID-19 pandemic and the use of chemical weapons in the Syria conflict have provided a stark reminder of the plethora of chemical and biological threats that soldiers, medical personnel and first responders face during routine and emergency operations.

Personnel safety relies on protective equipment which, unfortunately, still leaves much to be desired. For example, high breathability (i.e., the transfer of water vapor from the wearer’s body to the outside world) is critical in protective military uniforms to prevent heat-stress and exhaustion when soldiers are engaged in missions in contaminated environments. The same materials (adsorbents or barrier layers) that provide protection in current garments also detrimentally inhibit breathability.

To tackle these challenges, a multi-institutional team of researchers led by Lawrence Livermore National Laboratory (LLNL) scientist Francesco Fornasiero has developed a smart, breathable fabric designed to protect the wearer against biological and chemical warfare agents. Material of this type could be used in clinical and medical settings as well. The work was recently published online in Advanced Functional Materials and represents the successful completion of Phase I of the project, which is funded by the Defense Threat Reduction Agency through the Dynamic Multifunctional Materials for a Second Skin “D[MS]²” program.

A group of scientists led by Teruki Honma of the RIKEN Center for Biosystems Dynamics Research and including collaborators from Hoshi University and Mizuho Information & Research Institute have released key data on the proteins associated with the novel coronavirus that causes COVID-19. As a means to facilitate the development of anti-COVID-19 therapeutics, crystal structures of dozens of drug targets including the virus’s main protease, RNA dependent RNA polymerase, and S protein have been published by Protein Data Bank (PDB). The research group has performed ab initio quantum chemical calculations based on the crystal structures using the fragment molecule orbital method, and published the data at FMODB as a database for data acquired using that method. According Honma, “We hope that this data will help scientists quickly develop therapies for this devastating virus. We will continue to perform FMO calculations on newly released protein structures and update our data. This data will be important by allowing an understanding of the precise energy data for interactions between drug candidates and virus proteins.”

The data is available at FMODB: The database of quantum mechanical data based on the FMO method.

There is no vaccine or specific treatment for COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2.

Since the outbreak began in late 2019, researchers have been racing to learn more about SARS-CoV-2, which is a strain from a family of viruses known as coronavirus for their crown-like shape.

Northeastern chemical engineering professor Thomas Webster, who specializes in developing nano-scale medicine and technology to treat diseases, is part of a contingency of scientists that are contributing ideas and technology to the Centers for Disease Control and Prevention to fight the COVID-19 outbreak.

Continue reading “Here’s how nanoparticles could help us get closer to a treatment for COVID-19” »

Recently, Prof. Yang Xueming from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences and Prof. Yang Tiangang from the Southern University of Science and Technology discussed significant advances in the study of quantum resonances in atomic and molecular collisions at near absolute zero temperature. Their article was published in Science on May 7.

The rules of quantum mechanics govern all atomic and molecular collision processes. Understanding the quantum nature of atomic and molecular collisions is essential for understanding energy transfer and chemical reaction processes, especially in the low collisional energy region, where quantum effect is the most prominent.

A remarkable feature of quantum nature in atomic and molecular collision is quantum scattering resonances, but probing them experimentally has been a great challenge due to the transient nature of these resonances.

Exotic atoms in which electrons are replaced by other subatomic particles of the same charge allow deep insights into the quantum world. After eight years of ongoing research, a group led by Masaki Hori, senior physicist at the Max Planck Institute of Quantum Optics in Garching, Germany, has now succeeded in a challenging experiment: In a helium atom, they replaced an electron with a pion in a specific quantum state and verified the existence of this long-lived “pionic helium” for the very first time. The usually short-lived pion could thereby exist 1000 times longer than it normally would in other varieties of matter. Pions belong to an important family of particles that determine the stability and decay of atomic nuclei. The pionic helium atom enables scientists to study pions in an extremely precise manner using laser spectroscopy. The research is published in this week’s edition of Nature.

For eight years, the group worked on this challenging experiment, which has the potential to establish a new field of research. The team experimentally demonstrated for the first time that long-lived pionic helium atoms really exist. “It is a form of chemical reaction that happens automatically,” explains Hori. The exotic atom was first theoretically predicted in 1964 after experiments at that time pointed toward its existence. However, it was considered extremely difficult to verify this prediction experimentally. Usually, in an atom, the extremely short-lived pion decays quickly. However, in pionic helium, it can be conserved in a sense so it lives 1000 times longer than it normally does in other atoms.

North Korea has an active nuclear weapons program & has repeatedly tested nuclear explosive devices. It is also believed to possess biological & chemical weapons.