Lifeboat Foundation

Summary: New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may explain why some individuals with disease-causing mutations remain symptom-free. This selective gene inactivation, known as monoallelic expression, affects about 1 in 20 genes and varies between cell types.

The study shows that in families with genetic disorders, the active copy of a gene often determines disease severity. These findings challenge traditional genetic paradigms and suggest new approaches to diagnosing and treating inherited diseases.

In a shocking turn of events, a surgeon operating on a cancer patient managed to contract the deadly disease in what is believed to be an unprecedented case. The doctor was performing surgery on a 32-year-old German man suffering from a rare type of cancer when he accidentally “transplanted” the disease into himself.

This occurred when cells from the patient’s tumor seeped into a cut on the surgeon’s hand. Despite immediate disinfection and bandaging, the 53-year-old medic noticed a hard lump developing at the base of his middle finger five months later.

A hand specialist identified the lump as a malignant tumor genetically identical to cancer suffered by his former patient. Doctors treating him concluded that he had contracted cancer when his patient’s tumor cells seeped into the cut.

In china their resources are getting overwhelmed and it seems to be similar to covid 19. I think it could be another pandemic in weeks globally.

A mysterious virus known as HMPV (human metamnemovirus) is reportedly spreading in China, raising concerns due to its similarities with the COVID-19 outbreak.

It was easy to miss Dr. Robert Gray’s quick movements, tapping the screen of his smartphone at the beginning and end of patient visits on a recent day.

But Gray said those fast finger taps have changed his life. He was tapping an app that records discussions during his appointments and then uses artificial intelligence to find the relevant information, summarize it and zap it, within seconds, into each patient’s electronic medical record.

The technology was meticulously documenting each visit so Gray didn’t have to.

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The work, published today in Nature, marks a significant step forward in our ability to study how the human body takes shape during early development.

The notochord, a rod-shaped tissue, is a crucial part of the scaffold of the developing body. It is a defining feature of all animals with backbones and plays a critical role in organising the tissue in the developing embryo.

Continue reading “Timely TGFβ signalling inhibition induces notochord” »

A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, judgement, and awareness behind Alzheimer’s disease.

Blocking this pathway in mouse brains modeled on Alzheimer’s prevented damage to their synapse connections and reduced the buildup of potentially toxic tau proteins – both hallmarks of the condition.

The researchers, led by a team from the City University of New York (CUNY), believe this pathway – called the integrated stress response (ISR) – causes brain immune cells called microglia to go ‘dark’ and start damaging rather than benefiting the brain.

Read the full story at the link below 👇

A blood test that can predict how long vaccine immunity will last so people can get a booster jab earlier, is being developed by scientists.

Researchers have previously been unable to predict why some vaccines produce antibodies to fight infections that last for decades while in others immunity only lasts a few months.

Continue reading “Scientists develop vaccine test that predicts how long immunity lasts” »

Researchers have discovered nanocrystals that toggle between luminescent states swiftly, offering a promising advancement toward optical computing.

This technology could revolutionize data processing and artificial intelligence, making devices faster and more energy-efficient while expanding capabilities in telecommunications and medical imaging.

Breakthrough in Nanocrystal Technology.

Scientists at the Francis Crick Institute have generated human stem cell models1 which, for the first time, contain notochord – a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous system (the trunk).