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Archive for the ‘biotech/medical’ category: Page 6

Dec 30, 2024

Researchers Discover an Antiviral Function for Cellular RNA

Posted by in category: biotech/medical

RNA in cells performs an astounding number of functions. Messenger RNA carries the sequences of active genes to cellular machinery that turns it into proteins. And transfer RNA molecules are an essential part of the construction of those proteins. RNA molecules that have nothing to do with proteins can also help regulate genes and perform other cellular functions. Researchers have now shown that some RNA in cells also helps defend against viral infection, by aiding in the control of antiviral signaling. The findings have been reported in Science.

The researchers noted that RNA can be seen not only as a drug target, but also as a drug. RNA presents an opportunity for treating infections, or autoimmune diseases, they suggested.

Dec 30, 2024

AI-designed ‘nanocages’ mimic viral behavior for enhanced gene therapy

Posted by in categories: biotech/medical, genetics, robotics/AI

Researchers have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI). Their pioneering research was published in Nature on December 18.

Viruses are uniquely designed to encapsulate genetic material within spherical shells, enabling them to replicate and invade host cells, often causing disease. Inspired by these complex structures, researchers have been exploring artificial proteins modeled after viruses.

These “nanocages” mimic viral behavior, effectively delivering therapeutic genes to target cells. However, existing nanocages face significant challenges: their small size restricts the amount of genetic material they can carry, and their simple designs fall short of replicating the multifunctionality of natural viral proteins.

Dec 30, 2024

Simple scan can predict risks of serious heart problems

Posted by in category: biotech/medical

UVA scientists created an MRI method to study heart fat. This method identifies unhealthy fat that raises heart disease risks.

Dec 30, 2024

Research reveals how Fructose in Diet Enhances Tumor Growth

Posted by in category: biotech/medical

Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener in beverages and ultra-processed foods.

New research from Washington University in St. Louis shows that dietary fructose promotes tumor growth in animal models of melanoma, breast cancer and cervical cancer. However, fructose does not directly fuel tumors, according to the study published Dec. 4 in the journal Nature.

Instead, WashU scientists discovered that the liver converts fructose into usable nutrients for cancer cells, a compelling finding that could open up new avenues for care and treatment of many different types of cancer.

Dec 30, 2024

Heart doctor’s ‘surprising’ egg admission

Posted by in categories: biotech/medical, health

A cardiovascular surgeon has set the record straight about whether or not eggs are bad for your health. Full story.


It’s an age old debate – are eggs bad for your heart?

Dr Jeremy London, a cardiovascular surgeon from the US, posed the question to more than one million of his followers on social media and his answer may be surprising to some.

Continue reading “Heart doctor’s ‘surprising’ egg admission” »

Dec 30, 2024

AI tool helps predicts patient responses to cancer drugs

Posted by in categories: biotech/medical, robotics/AI

NCI researchers have developed an artificial intelligence (AI) tool that uses data from individual cells inside tumors to predict whether a person’s cancer will respond to a specific drug. These findings, published today in Nature Cancer, suggest that such single-cell RNA sequencing data could one day be used to help doctors more precisely match cancer patients with drugs that will be effective for their cancer.


An AI tool called PERCEPTION developed by NCI researchers could one day be used to help more precisely match patients with effective cancer drugs.

Dec 30, 2024

Why Dizziness Is Still a Mystery

Posted by in categories: biotech/medical, government, neuroscience

You can trigger a dizzy spell by standing up too fast, skipping lunch, spinning in a circle, or drinking too much alcohol. Dizziness can be linked to one’s ears, brain, heart, or metabolic system. The treatments, likewise, are heterogeneous. In benign paroxysmal positional vertigo, crystals in the inner ear canals become loose; physical repositioning, known as maneuvers, can usually treat it. For conditions of chronic dizziness called persistent postural perceptual dizziness (P.P.P.D.), vestibular rehabilitation and S.S.R.I.s, which normally treat depression and anxiety, seem to work better. Vestibular migraine is treated through the use of migraine-specific supplements or medications—which wouldn’t be advised for someone with the buildup of inner-ear fluid known as Ménière’s disease.

The sensation we call dizziness is a sort of general alarm system for the body—but just as a fire alarm can’t tell you where a fire is burning (or whether someone walked through the emergency exit by mistake), it doesn’t necessarily tell you what’s wrong. Dasgupta argued that diagnosing the causes of dizziness requires a lost clinical art known as anamnesis, or a holistic interview about the patient’s symptoms and their surrounding context. “This is like detective work,” he said. Diego Kaski, who treats vestibular patients as a consulting neurologist at the U.K.’s National Hospital for Neurology and Neurosurgery, tries to understand his patient’s symptoms by imagining that they are happening to him. He often relies on gestures: if people have vertigo, which includes the illusion of movement, “they might spin their finger or their hand around,” Kaski told me. Others will hold onto their heads or rock their upper bodies from side to side. Patient accounts tend to be psychological as well as physical. “You lose control of what your body is doing, and that can be quite a fearful experience,” Kaski said. Many dizzy people wonder whether they are dying.

While visiting doctor after doctor, I learned from a Google search about what sounded like a dizziness utopia: the German Center for Vertigo and Balance Disorders, or D.S.G.Z., in Munich. It was originally funded by the German federal government and, since 2019, has operated as an interdisciplinary center of the University Hospital of Munich.

Dec 30, 2024

The Strange Chemistry behind Millennia-Old Human Brains That Haven’t Rotted

Posted by in categories: biotech/medical, chemistry, neuroscience

Misfolded proteins may preserve postmortem brains well after other tissues have decayed.

By Kermit Pattison edited by Tanya Lewis

No part of our body is as perishable as the brain. Within minutes of losing its supply of blood and oxygen, our delicate neurological machinery begins to suffer irreversible damage. The brain is our most energy-greedy organ, and in the hours after death, its enzymes typically devour it from within. As cellular membranes rupture, the brain liquifies. Within days, microbes may consume the remnants in the stinky process of putrefaction. In a few years, the skull becomes just an empty cavity.

Dec 30, 2024

Effectiveness and Safety of Over-the-Counter Tooth-Whitening Agents Compared to Hydrogen Peroxide In Vitro

Posted by in category: biotech/medical

📚 🧑🏻‍🔬 By Dr. Lena Katharina Müller-Heupt et al.

MDPI university of nebraska medical center — UNMC.


This study investigated the whitening effect, cytotoxicity and enamel surface alterations induced by different over-the-counter (OTC) bleaching agents in comparison to hydrogen peroxide. Human teeth (n = 60) were randomly assigned into 6 groups (n = 10), stained with coffee solution for 7 d, followed by a whitening period of 7 d with either placebo, bromelain, sodium bicarbonate, sodium chlorite, PAP or hydrogen peroxide. Color measurements were performed with a spectrophotometer. Scanning electron micrographs (SEM) were taken to assess the enamel structure. Cytotoxicity of the tested substances was assessed based on the cell viability of primary human fibroblasts. The application of all whitening gels resulted in a greater color difference of the enamel (ΔE) in comparison to the negative control. Hydrogen peroxide caused the greatest color difference.

Dec 30, 2024

Evaluation of Candidates for Systemic Analgesia and General Anesthesia in the Emerging Model Cephalopod, Euprymna berryi

Posted by in category: biotech/medical

Cephalopods’ remarkable behavior and complex neurobiology make them valuable comparative model organisms, but studies aimed at enhancing welfare of captive cephalopods remain uncommon. Increasing regulation of cephalopods in research laboratories has resulted in growing interest in welfare-oriented refinements, including analgesia and anesthesia. Although general and local anesthesia in cephalopods have received limited prior study, there have been no studies of systemic analgesics in cephalopods to date. Here we show that analgesics from several different drug classes may be effective in E. berryi. Buprenorphine, ketorolac and dexmedetomidine, at doses similar to those used in fish, showed promising effects on baseline nociceptive thresholds, excitability of peripheral sensory nerves, and on behavioral responses to transient noxious stimulation.

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