Lifeboat Foundation

Mayo Clinic researchers found a noncellular substance suggested improvement in restoring muscle function and bladder control in preclinical models. The teams of Atta Behfar, M.D., Ph.D. and Emanuel Trabuco, M.D., led this research in a collaboration between Mayo Clinic Departments of Cardiovascular Medicine and Obstetrics and Gynecology. The paper is published in NPJ Regenerative Medicine.

“Surgical treatment for stress urinary incontinence, a condition afflicting 25 million women, has significantly declined over concerns about negative side effects,” says Dr. Trabuco. “This has led many women to delay therapy and suffer needlessly. We hope to develop a minimally invasive, noncellular, exosome-based approach to muscle regeneration for urinary incontinence that not only targets the underlying cause of the condition but also avoids the problem with invasive surgical options presently available.”

The research team used regenerative purified exosome product, known as PEP, derived from platelets to deliver messages into the cells of preclinical models. Exosomes are extracellular vesicles that are like a delivery service moving cargo from one cell to another, with instructions for targeting exact tissues that need repair. The study suggests that the use of purified exosome product alleviates stress urinary incontinence from musculoskeletal breakdown in animals. The team did not detect any infection or off-target toxicity with application of PEP.

Researchers at Japan’s National Institute for Materials Science (NIMS) have developed a device capable of taking hundreds of times more electrochemical measurements than conventional devices. By analyzing the device’s large amounts of data, the team has identified molecular mechanisms that enable electrogenic bacteria to efficiently generate electricity even when subjected to a wide range of electrode potentials.

This technique can also be used to analyze materials interacting with microorganisms (e.g., biodegradable plastics), potentially facilitating efforts to discover innovative microbial degradable materials.

The work was published in the journal Patterns in October, 2022.

Many people think about science in a fairly simplistic way: collect evidence, formulate a theory, test the theory. By this method, it is claimed, science can achieve objective, rational knowledge about the workings of reality. In this presentation I will question the validity of this understanding of science. I will consider some of the key controversies in philosophy of science, including the problem of induction, the theory-ladenness of observation, the nature of scientific explanation, theory choice, and scientific realism, giving an overview of some of the main questions and arguments from major thinkers like Popper, Quine, Kuhn, Hempel, and Feyerabend. I will argue that philosophy of science paints a much richer and messier picture of the relationship between science and truth than many people commonly imagine, and that a familiarity with the key issues in the philosophy of science is vital for a proper understanding of the power and limits of scientific thinking.

Slides to the presentation available here: http://www.slideshare.net/adam_ford/the-shaky-foundations-of…ames-fodor.

Continue reading “James Fodor — The Shaky Foundations of Science: An Overview of the Big Issues” »

Bernardo Kastrup, Carlo Rovelli and Patricia Churchland lock horns over the New Science of Consciousness.

00:00 Intro.
01:20 Patricia Churchland | On scientific evidence.
02:50 Bernardo Kastrup | On material idealism.
04:47 Carlo Rovelli | There is no hard problem of consciousness.
07:00 Robert Lawrence Kuhn | Will we ever be able to provide data explaining consciousness?

Continue reading “Can science crack the mystery of consciousness? | Bernardo Kastrup, Carlo Rovelli, and more” »

Tapping Biological Innovation In Nature For Humanity — Dr. Seemay Chou Ph.D., CEO, Arcadia Science

Dr. Seemay Chou, Ph.D. is the Co-Founder, CEO, and Board Member of Arcadia Science (https://www.arcadia.science/), a research and development company focusing on under researched areas in biology, with a specific focus on novel model organisms that haven’t been traditionally studied in the lab.

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An advanced optogenetic visual prosthesis for patients with serious blindness due to photoreceptor loss.

China has more than doubled the percentage of ‘highly cited researchers’ over the last five years.

China has a steady increase in the number of “high-impact scientists” than the United States, which is still the leader but has seen a steady drop over the years.

Research fuels the race for knowledge.

Continue reading “Survey: China is slowly diminishing US dominance over science” »

Evidence-Based And Actionable Health, Wellness And Longevity Solutions — Dr. Renee DeHaan, Ph.D. — VP, Science & AI, InsideTracker

Dr. Renée Deehan, Ph.D. is the VP of Science & Artificial Intelligence at InsideTracker (https://www.insidetracker.com/), and leads a science team that builds and mines the world’s largest data set of blood, DNA, fitness tracking and phenotypic data from healthy people, creating evidence-based solutions that are simple, clear, and actionable.

Continue reading “Dr Renée Deehan — VP, Science & AI, InsideTracker — Evidence-Based And Actionable Wellness Solutions” »