Lifeboat Foundation

Restorative neuroscience, the study to identify means to replace damaged neurons and recover permanently lost mental or physical abilities, is a rapidly advancing scientific field considering our progressively aging society. Redirecting immature neurons that reside in specific brain areas towards the sites of brain damage is an appealing strategy for the therapy of acute brain injury or stroke. A collaborative effort between the Center for Brain Research of Medical University of Vienna and the National Brain Research Program of Hungary/Semmelweis University in Budapest revealed that some mature neurons are able to reconfigure their local microenvironment such that it becomes conducive for adult-born immature neurons to extensively migrate. Thus, a molecular principle emerges that can allow researchers to best mobilize resident cellular reserves in the adult brain and guide immature neurons to the sites of brain damage.

The adult brain has limited capacity of self-repair.

In the aging Western society, acute brain damage and chronic neurodegenerative conditions (e.g. Alzheimer’s and Parkinson’s diseases) are amongst the most debilitating diseases affecting hundreds of millions of people world-wide. Nerve cells are particularly sensitive to microenvironmental insults and their loss clearly manifests as neurological deficit. Since the innate ability of the adult human brain to regenerate is very poor and confined to its few specialized regions, a key question in present-day neurobiology is how to establish efficient strategies that can replace lost neurons, guide competent cells to the sites of injury and facilitate their functional integration to regain lost functionality. “Cell replacement therapy” thus offers frontline opportunities to design potent therapeutic interventions.

Continue reading “Study offers novel principle to reroute neurons for brain repair” »

Researchers have shown that mice without the gene for PLCγ1 in their forebrains exhibit manic-like behaviors.

Combines, space, poetry, optics, stories, TV, cognitive computing, atomic food safety, astrophysics and quantum biology in a fun-packed programme for everyone.

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We celebrate her birthday and life but what fun is there to living so long when aging takes its toll? Science is aiming to do better, find out how here!

Today, February 21, is the birthday of Jeanne Louise Calment – the oldest verified human being ever, who managed to live an amazing 122 years and 164 days!

Jeanne was an independent and positive person, and she managed to live all alone until aged 110. After a fire in her apartment she moved into a nursing home, but even there she was still able to take care of herself. However, shortly before her 115th birthday she fell down a stairway and never fully recovered her ability to walk.

Continue reading “The record lifespan of 122 years could be surpassed via innovative medicine” »

For those interested in life extension and bionic / cyborg type enhancements, this CMU Robotics Institute Seminar gives an overview of the background and current developments in artificial vision. José Alain Sahel MD is a world leading ophthalmologist with a lengthy bio and numerous honors and appointments.

In the future, if you’re going blind, these sight restoration technologies may be used to remediate your vision loss.

Three major ideas are covered. 1) Implanting arrays of tiny 3-color LEDs under a failed retina to stimulate still-okay cells, and 2) using gene therapy to express a novel photoreceptor, borrowed from algae, to restore a form of sight to failed cells. These can be done together. Lots of studies in mice, primates, and humans. Some coverage is also given to 3) directly implanting electronics in the brain to send complete images to vision centers, but this is still at an early stage.

Continue reading “Artificial Vision, Artificial Retina, Optogenetics, José Alain Sahel MD, CMU RI Seminar” »

Nice. My friend Alex Zhavoronkov will appreciate this article.

Feb. 16 (UPI) — Researchers at McGill University in Montreal have found that targeting the internal circadian or biological clock of cancer cells can affect growth.

Most cells in the human body have an internal clock that sets a rhythm for activities of organs depending on the time of day. However, this internal clock in cancer cells does not function at all or malfunctions.

Continue reading “Study finds targeting biological clock in cells slows cancer” »

Not too shock by this given other transplant patient’s stories of memories, etc.

There are a lot of outrageous claims being made within the halls of neuroscience and artificial intelligence. Whether exaggerations, wishful thinking, the dreams of the egocentric and megalomaniacal to be immortal, or just drumming up funding for a never-ending round of “scientific investigation,” the year 2045 seems to always be cited as a target date.

Continue reading “Company Claims Brain Transplants Could Bring Back the Dead by 2045” »

New research on Parkinson and holds additional insights in cell & neuro technology.

Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration and tissue atrophy, and in accelerated aging. To promote basal levels of the process in pathological settings, we previously screened a small molecule library for novel autophagy-enhancing factors that inhibit the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autophagic membrane formation. Here we identify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson’s and Huntington’s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.