Lifeboat Foundation

Dopamine is a type of neurotransmitter that can provide an intense feeling of reward. It has been a long-standing assumption that most, if not all, dopamine neurons solely respond to rewards or reward-predicting cues. However, a study in mice led by researchers at Northwestern University reveals dopamine may also control movements. The researchers uncovered that one genetic subtype fires when the body moves and that these neurons do not respond to rewards at all.

The findings are published in Nature Neuroscience in an article titled, “Unique functional responses differentially map onto genetic subtypes of dopamine neurons,” and shed new light on the brain which may lead to new research on Parkinson’s disease, which is characterized by the loss of dopamine neurons yet affects the motor system.

“Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli,” the researchers wrote. “Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1, and Anxa1, each have a unique set of responses to rewards, aversive stimuli, and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes.”

The device was equipped with infrared technology.

A police drone equipped with infrared capabilities has risen as a hero in the search for a missing person with dementia that disappeared from a Delta hospital on July 29. Delta is a city located in British Columbia, Canada.

This is according to a report by Global News published on Wednesday.

Continue reading “Police use drone to find missing person with dementia” »

Johns Hopkins University (JHU) researchers have developed an experimental brain cancer treatment that not only cured 100% of mice that received it, but also trained their immune systems to fight future cancers.

The challenge: Glioblastoma is a rare but aggressive type of brain cancer — only 5% of patients live for more than five years after they’re diagnosed, and the average survival time is just 12–18 months. It is considered the deadliest kind of cancer.

Continue reading “New gel destroys brain cancer in 100% of treated mice” »

The cognition needed to support cooperation in its multifaceted forms varies in different scenarios. In this Review, Melis and Raihani argue that whether individuals must recognize interaction partners and whether cooperative interactions need investment repayment can differentiate the cognitive demand posed.

Sound waves combined with tiny bubbles in the bloodstream can push drugs into the brain and tough-to-reach tumors.

Yang and co-workers state that “using inducible changes to the epigenome, we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging.” There is extensive evidence that the key reagent, restriction endonuclease I-PpoI, is cytotoxic. Moreover, the corresponding author published two papers—neither cited—showing that I-PpoI targeted to specific cell types causes a p53 response and cell elimination within a month. Despite globally inducing I-PpoI activation for seven times as long as required to induce a progeric effect, no analysis of mice during this critical window was presented. No significant conclusion of Yang was demonstrated.

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Global Workspace Theory (GWT) can be compared to a theater of mind, in which conscious contents resemble a bright spot on the stage of immediate memory, selected by a spotlight of attention under executive guidance. Only the bright spot is conscious; the rest of the theater is dark and unconscious. GWT has been implemented in a number of explicit and testable global workspace models (GWM’s). These specific GW models suggest that conscious experiences recruit widely distributed brain functions that are mostly unconscious (unreportable). A large body of new findings support that view. For example, brain experiments show that while unconscious visual stimuli evoke high activity in visual cortex, identical conscious stimuli reveal an additional spread of high brain activity to frontal and parietal lobes (Dehaene, 2001). Similar results have been found for hearing, touch, pain, and sensorimotor skills (Baars, 2002). The conscious waking state supports such fast, flexible, and widespread brain interactions, while unconscious states do not (Baars et al, 2004). These findings illustrate the ability of the GW framework to suggest novel and falsifiable hypotheses.

In this work, we provide a brief overview of Global Workspace Theory (GWT), along with recent developments and clarifications of modern neuroscientific evidence. GWT started in the 1980s as a purely psychological theory of conscious cognition, and has become a prominent approach in scientific studies of consciousness (Mashour et al., 2020). Based on today’s far more detailed understanding of the brain, GWT has adapted to new waves of evidence. The brain-based version of GWT is called Global Workspace Dynamics (GWD) (Baars et al., 2013; Baars and Geld, 2019) precisely because the cortex is viewed as a “unified oscillatory machine” (Steriade, 1999). GWT therefore joins other theories in viewing consciousness as the product of highly integrated and widespread cortico-thalamic (C-T) activity, following a long trail of evidence (Dehaene et al., 1998).

Here we aim to clarify some empirical questions that have been raised, and review evidence that the prefrontal and posterior regions support dynamic global workspace functions, in agreement with several other authors. Static, gross anatomical divisions are superseded by the dynamical connectome of cortex.

We aim to correct the following misunderstandings. In a recent paper, Raccah et al. (2021) claimed that the prefrontal cortex (PfC) is not causally involved in enabling consciousness, based on a review of intracranial electrical stimulation (iES) experiments. We will show that Raccah et al.’s claim that the prefrontal cortex (PfC) does not support consciousness is incorrect.