The Stoic philosophical school shares several ideas with modern attempts at prolonging human lifespan. The Stoics believed in a non-dualistic, deterministic paradigm, where logic and reason formed part of their everyday life. The aim was to attain virtue, taken to mean human excellence.

I have recently described a model specifically referring to indefinite lifespans, where human biological immortality is a necessary and inevitable consequence of natural evolution (for details see www.elpistheory.info and for a comprehensive summary see http://cid-3d83391d98a0f83a.office.live.com/browse.aspx/Immo…=155370157).

This model is based on a deterministic, non-dualistic approach, described by the laws of Chaos theory (dynamical systems) and suggests that, in order to accelerate the natural transition from human evolution by natural selection to a post-Darwinian domain (where indefinite lifespans are the norm) , it is necessary to lead a life of constant intellectual stimulation, innovation and avoidance of routine (see http://www.liebertonline.com/doi/abs/10.1089/rej.2005.8.96?journalCode=rej and http://www.liebertonline.com/doi/abs/10.1089/rej.2009.0996) i.e. to seek human virtue (excellence, brilliance, and wisdom, as opposed to mediocrity and routine). The search for intellectual excellence increases neural inputs which effect epigenetic changes that can up-regulate age repair mechanisms.

Thus it is possible to conciliate the Stoic ideas with the processes that lead to both technological and developmental Singularities, using approaches that are deeply embedded in human nature and transcend time.

The summer 2010 “Humanity+ @ Harvard — The Rise Of The Citizen Scientist” conference is being held, after the inaugural conference in Los Angeles in December 2009, on the East Coast, at Harvard University’s prestigious Science Hall on June 12–13. Futurist, inventor, and author of the NYT bestselling book “The Singularity Is Near”, Ray Kurzweil is going to be keynote speaker of the conference.

Also speaking at the H+ Summit @ Harvard is Aubrey de Grey, a biomedical gerontologist based in Cambridge, UK, and is the Chief Science Officer of SENS Foundation, a California-based charity dedicated to combating the aging process. His talk, “Hype and anti-hype in academic biogerontology research: a call to action”, will analyze the interplay of over-pessimistic and over-optimistic positions with regards of research and development of cures, and propose solutions to alleviate the negative effects of both.

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Another risk is loss of human rationality, while preserving human life. In a society there are always so many people with limited cognitive abilities, and most of the achievements are made by a small number of talented people. Genetic and social degradation, reducing the level of education, loss of skills of logic can lead to a temporary decrease in intelligence of individual groups of people. But as long as humanity is very large in population, it is not so bad, because there will always be enough intelligent people. Significant drop in population after nonglobal disaster may exacerbate this problem. And the low intelligence of the remaining people will reduce their chances of survival. Of course, one can imagine such an absurd situation that people are so degraded that by the evolutionary path new species arise from us, which is not having a full-fledged intelligence — and that back then this kind of evolving reasonable, developed a new intelligence.
More dangerous is decline of intelligence because of the spread of technological contaminants (or use of a certain weapon). For example, I should mention constantly growing global arsenic contamination, which is used in various technological processes. Sergio Dani wrote about this in his article “Gold, coal and oil.” http://sosarsenic.blogspot.com/2009/11/gold-coal-and-oil-reg…is-of.html, http://www.medical-hypotheses.com/article/S0306-9877 (09) 00666–5/abstract
Disengaged during the extraction of gold mines in the arsenic remains in the biosphere for millennia. Dani binds arsenic with Alzheimer’s disease. In his another paper is demonstrated that increasing concentrations of arsenic leads to an exponential increase in incidence of Alzheimer’s disease. He believes that people are particularly vulnerable to arsenic poisoning, as they have large brains and longevity. If, however, according to Denis, in the course of evolution, people will adapt to high levels of arsenic, it will lead to a decline in the brain and life expectancy, resulting in the intellect of people will be lost.
In addition to arsenic contamination occurs among many other neurotoxic substances — CO, CO₂, methane, benzene, dioxin, mercury, lead, etc. Although the level of pollution by each of them separately is below health standards, the sum of the impacts may be larger. One reason for the fall of the Roman Empire was called the total poisoning of its citizens (though not barbarians) of lead from water pipes. Of course, they could not have knowledge about these remote and unforeseen consequences — but we also may not know about the many consequences of our affairs.
In addition to dementia is alcohol and most drugs, many drugs (eg, side effect in the accompanying sheets of mixtures of heartburn called dementia). Also rigid ideological system, or memes.
Number of infections, particularly prion, also leads to dementia.
Despite this, the average IQ of people is growing as life expectancy.

I recently began to worry that something/someone, some field, force, disease, prion, virus, bad luck and/or natural causes could threaten and perhaps destroy the most valuable entity in the universe, an entity more valuable than life itself. Consciousness. What good is life extension without conscious awareness? What is consciousness?

We know the brain works a lot like a computer, with neuron firings and synapses acting like bit states and switches. Brain-as-computer works very well to account for sensory processing, control of behavior, learning and other cognitive functions. These functions may in some cases be non-conscious, and other times associated with conscious experience and control. Scientists seek the distinction – the essential feature, or trick for consciousness.

Some suggest there is no trick, consciousness emerges as a by-product of cognitive computation among neurons. Others say we don’t know, that consciousness may indeed require some feature related to, but not quite the same as neuron-to-neuron cognition.

In either case, humans and other creatures could in principle become devoid of consciousness while maintaining cognitive behaviors, appearing more-or-less normal to outside observers. Such hypothetical non-conscious behaving entities are referred to in literature, films and philosophical texts as ‘zombies’. Philosopher David Chalmers introduced the philosophical zombie, a test case for whether or not consciousness is distinct from cognitive neurocomputation.

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Artificial brain ’10 years away’

A detailed, functional artificial human brain can be built within the next 10 years, a leading scientist has claimed.

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Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease

In these financially difficult times many funding bodies have to prioritise projects based around long established hypotheses. Projects involving new avenues of investigation can receive very positive comments by scientific reviewers, yet are rarely funded, as they almost always appear risky compared with projects largely confirming or expanding existing ideas. Such conservative projects are almost guaranteed to produce useful data, though with modest impact. This situation can mean that research proposals with the potential to transform our understanding of a disease and offer new approaches to its treatment never reach the threshold for funding and are not implemented, even though the potential and quality of the science is acknowledged by reviewers and funding panel.

It appears that our work examining a viral cause for Alzheimer’s disease is in this category. Despite our publishing a large number of potentially very exciting papers on this topic, and despite our research projects being reviewed favourably by scientific referees, few funding panels are prepared to commit resources to fund our work, as by doing so they deny funding to other more straightforward, very low risk projects.

We are therefore actively seeking sponsorship for several projects of varying costs to investigate the interaction of virus and specific genetic factor, the pathways of viral damage in the brain, and the effects of antiviral agents. All the projects would provide significant evidence strengthening the case for trialling antiviral agents in Alzheimer’s disease.

Antiviral agents would inhibit a likely major cause of the disease in contrast to current treatments, which merely inhibit the symptoms.

If any Lifeboat member knows of a company or individual that would be interested in sponsoring some of our research on Alzheimer’s disease then please contact me for further details.

Ruth Itzhaki

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