Lifeboat Foundation

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.

The findings, published in the Journal of Nanobiotechnology (“Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials”), could eventually help bring this treatment to patients with these and other neurodegenerative diseases, according to the authors.

Gold nanocrystals suspended in a water buffer represent a novel therapeutic agent developed by Clene Nanomedicine for neurodegenerative conditions. This nanomedicine, called CNM-Au8, is being investigated to treat patients with multiple sclerosis and Parkinson’s disease in clinical trials at UT Southwestern. (Illustration: Random 42/Source: Clene Nanomedicine)

Janus nanosheets bring unprecedented control to preparation of nanoscrolls.

Researchers from Tokyo Metropolitan University have come up with a new way of rolling atomically thin sheets of atoms into “nanoscrolls.” Their unique approach uses transition metal dichalcogenide sheets with a different composition on either side, realizing a tight roll that gives scrolls down to five nanometers in diameter at the center and micrometers in length. Control over the nanostructure in these scrolls promises new developments in catalysis and photovoltaic devices.

Advancements in Nanotechnology.

Researchers achieved a major breakthrough by crafting nanoscrolls using Janus nanosheets.

Discover the future of nanotechnology as Tokyo scientists pioneer a method to roll atomically thin sheets into nanoscrolls.

How Columbia conservators, Nano Initiative scientists, and a music scholar used state-of-the-art technology to examine a score.

The nanospace confinement of a magnetic nanoparticle within a porous cage, coupled with an encodable DNA clutch interface, enables a remotely powered and controlled rotary nanomotor that is autoresponsive to its microenvironment.

In a new Nature Communications study, researchers have explored the construction of genetic circuits on single DNA molecules, demonstrating localized protein synthesis as a guiding principle for dissipative nanodevices, offering insights into artificial cell design and nanobiotechnology applications.

The term “genetic circuit” is a metaphorical description of the complex network of genetic elements (such as genes, promoters, and regulatory proteins) within a cell that interact to control gene expression and cellular functions.

In the realm of artificial cell design, scientists aim to replicate and engineer these genetic circuits to create functional, self-contained units. These circuits act as the molecular machinery responsible for orchestrating cellular processes by precisely regulating the production of proteins and other molecules.

A new protective layer developed by researchers improves gold catalysts’ durability, potentially expanding their industrial applications and efficiency. Credit: SciTechDaily.com.

A protective layer applied to gold nanoparticles can boost its resilience.

For the first time, researchers including those at the University of Tokyo discovered a way to improve the durability of gold catalysts by creating a protective layer of metal oxide clusters. The enhanced gold catalysts can withstand a greater range of physical environments compared to unprotected equivalent materials.

Scientists have been making nanoparticles out of DNA strands for two decades, manipulating the bonds that maintain DNA’s double-helical shape to sculpt self-assembling structures that could someday have jaw-dropping medical applications.

The study of DNA nanoparticles, however, has focused mostly on their architecture, turning the genetic code of life into components for fabricating minuscule robots. A pair of Iowa State University researchers in the genetics, development, and cell biology department—professor Eric Henderson and recent doctoral graduate Chang-Yong Oh—hope to change that by showing nanoscale materials made of DNA can convey their built-in genetic instructions.

“So far, most people have been exploring DNA nanoparticles from an engineering perspective. Little attention has been paid to the information held in those DNA strands,” Oh said.

In a recent breakthrough, DNA sequencing technology has uncovered the culprit behind cassava witches’ broom disease: the fungus genus Ceratobasidium. The cutting-edge nanopore technology used for this discovery was first developed to track the COVID-19 virus in Colombia, but is equally suited to identifying and reducing the spread of plant viruses.

The findings, published in Scientific Reports, will help plant pathologists in Laos, Cambodia, Vietnam and Thailand protect farmers’ valued cassava harvest.

“In Southeast Asia, most smallholder farmers rely on cassava. Its starch-rich roots form the basis of an industry that supports millions of producers. In the past decade, however, cassava witches’ broom disease has stunted plants, reducing harvests to levels that barely permit affected farmers to make a living,” said Wilmer Cuellar, Senior Scientist at the Alliance of Bioversity and CIAT.