Lifeboat Foundation

One of the biggest existential challenges that transhumanists face is that most people don’t believe a word we’re saying, however entertaining they may find us. They think we’re fantasists when in fact we’re talking about a future just over the horizon. Suppose they’re wrong and we are right. What follows? Admittedly, we won’t know this until we inhabit that space ‘just over the horizon’. Nevertheless, it’s not too early to discuss how these naysayers will be regarded, perhaps as a guide to how they should be dealt with now.

So let’s be clear about who these naysayers are. They hold the following views:

1) They believe that they will live no more than 100 years and quite possibly much less.
2) They believe that this limited longevity is not only natural but also desirable, both for themselves and everyone else.
3) They believe that the bigger the change, the more likely the resulting harms will outweigh the benefits.

Now suppose they’re wrong on all three counts. How are we to think about such beings who think this way? Aren’t they the living dead? Indeed. These are people who live in the space of their largely self-imposed limitations, which function as a self-fulfilling prophecy. They are programmed for destruction – not genetically but intellectually. Someone of a more dramatic turn of mind would say that they are suicide bombers trying to manufacture a climate of terror in humanity’s existential horizons. They roam the Earth as death-waiting-to-happen. This much is clear: If you’re a transhumanist, ordinary people are zombies.

Continue reading “We May Look Crazy to Them, But They Look Like Zombies to Us: Transhumanism as a Political Challenge” »

At an industrial park in San Leandro, a small group of artists, scientists and tech enthusiasts are trying to sell an alternative to death: cryonic suspension. The company, Transtime, preserves the recently deceased in liquid nitrogen under the assumption that one day the frozen cadavers can be revived.

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A superb and fun interview with Dr Michael Fossel and why he believes telomerase therapy is the most direct route to dealing with aging.

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An interesting paper about Urchins and how some species effectively do not age (like some lobsters) by expressing telomerase.

Note the researcher makes the classic mistake about telomere biology not understanding the correlation between a short lived species which has longer telomeres and one that has negligible senescence and considerably shorter telomeres. The same applies to mice and men, mice have much longer telomeres than us but live about 3 years max.

The frequently made misconception about telomeres is that telomere length defines or causes aging, it does not. An organism’s telomere length has little to do with how long it lives or how fast it ages. People often point out, some animals, such as mice, have long telomeres and a short lifespan, while other animals, such as humans, have much shorter telomeres but longer lifespan.

Continue reading “Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin” »

Irina Conboy is making some amazing advances in aging and rejuvenation research at Berkley. The Conboy lab has been steadily making progress in regenerative medicine and is potentially a few years from having something viable in terms of regenerative medicine. It would be amazing if the community could get behind a single breakthrough project like Irina is working on and making sure this technology arrives soon.

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SpaceX Falcon 9 v1.1 rocket with NASA CRS 7 Dragon launches from Cape Canaveral Air Force Station’s Space Launch Complex 40 in Florida photo credit Carleton Bailie SpaceFlight Insider.

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OK. In scientific terms, it is only a ‘hypothesis’ — the reverse of the ‘Disposable Soma’ theory of ageing. Here how it goes.

For the past several decades, the Disposable Soma theory of ageing has been enjoying good publicity and a lively interest from both academics and the public alike. It stands up to scientific scrutiny, makes conceptual sense and fits well within an evolutionary framework of ageing. The theory basically suggests that, due to energy resource constraints, there is a trade-off between somatic cell and germ cell repair. As a result, germ cells are being repaired effectively and so the survival of the species is assured, at a cost of individual somatic (bodily) ageing and death. To put it very simply, we are disposable, we age and die because all the effective repair mechanisms have been diverted to our germ cell DNA in order to guarantee the survival of our species.

The theory accounts for many repair pathways and mechanisms converging upon the germ cell, and also for many of those mechanisms being driven away from somatic cell repair just to ensure germ cell survival. In the past two or three years however, it is increasingly being realised that this process is not unidirectional (from soma to germ), but it is bi-directional: under certain circumstances, somatic cells may initiate damage that affects germ cells, and also that germ cells may initiate repairs that benefit somatic cells!

I can’t even begin to describe how important this bi-directionality is. Taking this in a wider and more speculative sense, it is, in fact, the basis for the cure of ageing. The discovery that germ cells can (or are forced to) relinquish their repair priorities, and that resources can then be re-allocated for somatic repairs instead, means that we may be able to avoid age-related damage (because this would be repaired with greater fidelity) and, at the same time, avoid overpopulation (as our now damaged genetic material would be unsuitable for reproduction).

Continue reading “The ‘Indispensable Soma’ theory of ageing” »

A nice article from Kurzweil AI on a transhumanist & life extension bus tour. If you haven’t contributed, please do so! Anyone from any country can donate, and even $5 helps! http://www.kurzweilai.net/transhumanist-party-presidential–… and the Indiegogo campaign: https://www.indiegogo.com/…/immortality-bus-with…/x/6837406…

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Google Ventures and the Search for Immortality

Bill Maris has $425 million to invest this year, and the freedom to invest it however he wants. He’s looking for companies that will slow aging, reverse disease, and extend life.

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