Lifeboat Foundation

Everything starts to go downhill as we get older and muscle is no exception; even simple tasks become challenging as we lose bone and muscle. Now research has identified a protein behind this age-related decline and therapeutic molecules that can fight it, helping individuals stay healthy and strong for longer.

A team at the Univesity of Iowa has discovered that a protein called ATF4 might be behind muscular decline. ATF 4 is a transcription factor, which means it tells the body to activate or regulate certain genes. ATF4 seems to change skeletal muscle with age, reducing protein synthesis and overall mass.

”Many of us know from our own experiences that muscle weakness and atrophy are big problems as we become older”

Continue reading “Aging Causes Muscle Weakness And Atrophy, But Can We Treat It?” »

As we grow older, we lose strength and muscle mass. However, the cause of age-related muscle weakness and atrophy has remained a mystery.

Scientists at the University of Iowa have discovered the first example of a protein that causes muscle weakness and loss during aging. The protein, ATF4, is a transcription factor that alters gene expression in skeletal muscle, causing reduction of muscle protein synthesis, strength, and mass. The UI study also identifies two natural compounds, one found in apples and one found in green tomatoes, which reduce ATF4 activity in aged skeletal muscle. The findings, which were published online Sept. 3 in the Journal of Biological Chemistry, could lead to new therapies for age-related muscle weakness and atrophy.

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https://youtube.com/watch?v=QwfH1gYkXTw

The young have always outnumbered the old, but as fertility rates drop and lifespans go up, this is starting to change.

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The biology of aging is traditionally studied in fast-living organisms such as mice, worms and fruit flies. Short-lived species certainly have a role to play in this field, but they are only the tip of the iceberg.

Within the natural ecosystem, organisms display a range of aging processes, most often accelerated aging, or gradual aging (in the case of humans), but also, a range of species with slow or even negligible aging, which is known as negligible senescence. Unlike humans, such species have a constant mortality rate for the duration of their lifespan, as well as a constant or even increasing fertility rate. The number of negligibly senescent species which we are currently aware of is likely to grow as more and more are studied and discovered, both in the wild and in the lab.

By studying the processes which give these creatures longer lifespans, there is the possibility that they could be recreated in humans in order to extend our own. How negligible senescence is achieved by each individual species varies, but here are five of the most common traits.

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Humans continue to seek after it, but other life forms have already achieved it.

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Interesting article in The Telegraph on biohacking and recent Grindfest, where the Immortality Bus stopped:

Immortality aside, DIY “bio-hacking” could provide solutions to everyday problems, despite the risks involved.

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Calorie restriction (CR) is big news in the anti-aging world, but how effective is it really? The evidence might be more mixed than you think.

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First major story on Immortality Bus from embedded journalist with Vox:

His campaign’s ’70s RV that’s been rebuilt to look like a giant coffin.

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