Lifeboat Foundation

Interesting article by CNET, the leading tech site in traffic, on how a strong science, longevity, and technology platform could end up in Washington in 2016:

CNET exclusive: The only pro-immortality candidate could eventually team up with one of the big names in the race.

The new entity will focus on a haemophilia pipeline utilising the XTEN half-life extension technology, bispecific antibodies and gene therapies.

Biogen announced yesterday it is planning to spin-out its haemophilia business into an independent, public firm based in Boston, Massachusetts by early next year.

Management said during a conference call this was the right time for a spin-out as Biogen’s haemophilia business has matured.

Continue reading “Biogen haemophilia spin-out to develop gene therapies and long-acting factors” »

When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That’s the conclusion of a new study that tracked developing cells in an adult mouse brain in real time.

New brain cells began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. The observation, described May 2, 2016 in Nature Neuroscience, suggests that new cells in the adult brain have more in common with those in the embryonic brain than scientists previously thought and could have implications for understanding diseases including autism, intellectual disabilities and schizophrenia.

“We were surprised by the extent of the pruning we saw,” says senior author Rusty Gage, a professor in Salk’s Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.

What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism? I’m guessing you’d be like: surprised .

So, here’s the deal. My biohacker friends led by Peter Fedichev and Sergey Filonov in collaboration with my old friend and the longevity record holder Robert Shmookler Reis published a very cool paper. They proposed a way to quantitatively describe the two types of aging – negligible senescence and normal aging. We all know that some animals just don’t care about time passing by. Their mortality doesn’t increase with age. Such negligibly senescent species include the notorious naked mole rat and a bunch of other critters like certain turtles and clams to name a few. So the paper explains what it is exactly that makes these animals age so slowly – it’s the stability of their gene networks.

What does network stability mean then? Well, it’s actually pretty straightforward – if the DNA repair mechanisms are very efficient and the connectivity of the network is low enough, then this network is stable. So, normally aging species, such as ourselves, have unstable networks. This is a major bummer by all means. But! There is a way to overcome this problem, according to the proposed math model.

Continue reading “10 responses to ‘Hacking Aging’” »

Making software immortal; Raytheon is trying to make it a reality.

CAMBRIDGE, Mass., May 2, 2016 /PRNewswire/ — A team led by Raytheon BBN Technologies is developing methods to make mobile applications viable for up to 100 years, despite changes in hardware, operating system upgrades and supporting services. The U.S. Air Force is sponsoring the four-year, $7.8 million contract under the Defense Advanced Research Projects Agency’s Building Resource Adaptive Software Systems program.

“Mobile apps are pervasive in the military, but frequent operating system upgrades, new devices and changing missions and environments require manual software engineering that is expensive and causes unacceptable delays,” said Partha Pal, principal scientist at Raytheon BBN. “We are developing techniques to eliminate these interruptions by identifying the way these changes affect application functionality and modifying the software.”

Continue reading “Raytheon developing technology to make software ‘immortal’” »

Ask an Information Architect, CDO, Data Architect (Enterprise and non-Enterprise) they will tell you they have always known that information/ data is a basic staple like Electricity all along; and glad that folks are finally realizing it. So, the same view that we apply to utilities as core to our infrastructure & survival; we should also apply the same value and view about information. And, in fact, information in some areas can be even more important than electricity when you consider information can launch missals, cure diseases, make you poor or wealthy, take down a government or even a country.

What is information? Is it energy, matter, or something completely different? Although we take this word for granted and without much thought in today’s world of fast Internet and digital media, this was not the case in 1948 when Claude Shannon laid the foundations of information theory. His landmark paper interpreted information in purely mathematical terms, a decision that dematerialized information forever more. Not surprisingly, there are many nowadays that claim — rather unthinkingly — that human consciousness can be expressed as “pure information”, i.e. as something immaterial graced with digital immortality. And yet there is something fundamentally materialistic about information that we often ignore, although it stares us — literally — in the eye: the hardware that makes information happen.

As users we constantly interact with information via a machine of some kind, such as our laptop, smartphone or wearable. As developers or programmers we code via a computer terminal. As computer or network engineers we often have to wade through the sheltering heat of a server farm, or deal with the material properties of optical fibre or copper in our designs. Hardware and software are the fundamental ingredients of our digital world, both necessary not only in engineering information systems but in interacting with them as well. But this status quo is about to be massively disrupted by Artificial Intelligence.

Continue reading “How AI will make information akin to electricity” »

We’re all trying to discover immortaility through anti-aging. And, all of this time we had the perfect example running marathons. Would love to know her secret.

Ida Keeling continues to set a new mark for centenarians, breaking the World Record for the 100-yard dash for her age group (80 years and older) on Saturday in Philadelphia.

A DOCTOR who has dedicated his work to the quest for eternal life insists the record for the oldest living person will soon fall and someone already alive will keep going until they make 1,000.

Very eye opening: North America has the largest market for silent cancer therapeutic, followed by Europe.

Silent cancer refers to those types of cancer which are undiagnosed in early stages. This is due to asymptomatic nature of the disease which makes it difficult to identify the disease till it progresses to advanced stages. Major silent types of cancer include brain, cervix, esophagus, mouth and larynx, ovarian, pancreatic, kidney, and liver cancer. Some silent types of cancer such as ovarian cancer, esophageal cancer, and pancreatic cancer show symptoms in their early stages. Ovarian cancer occurs in epithelium or lining cells of the ovary. Major signs and symptoms of ovarian cancer include pain or cramps in the belly, nausea, abnormal vaginal bleeding, and bloating. Pancreatic cancer is one of the fastest growing types of cancer worldwide. Esophagus cancer is more common among the older population, compared to adults. This cancer is mainly treated by chemotherapy, surgery, and radiosurgery. Moreover, physicians also use combination therapy for the treatment of silent cancer. For instance, the combination of radiation therapy and chemotherapy is very effective in the treatment of silent cancer.

Continue reading “Silent Cancer Therapeutic Market — Historical, Current and Projected industry size and Recent Industry Trends by 2015 — 2021” »