Lifeboat Foundation

Sinclair lab enters human trials for DNA repair this year!

DNA is a critical part of the cell, it is the instruction manual for building cells. Whilst DNA is well protected within the cell nucleus damage does occur, therefore DNA repair is absolutely essential for cell function, cell survival and the prevention of cancer. The good news is cells are able to repair damaged DNA but the bad news is that this ability declines with aging for reasons as yet to be fully understood.

An exciting new study by researchers led by Dr. David Sinclair at Harvard Medical School shows a part of the process that enables cells to repair damaged DNA involving the signalling molecule NAD. This offers insight into how the body repairs DNA and why that repair system declines as we age. Before we get into the new research study let’s take a look at how DNA damage relates to aging and what NAD is.

Whilst looking through recent papers about biomarkers and this recent open access paper crossed my desk. The paper is the latest in a line of top to bottom reviews of aging biomarkers for humans. With companies like Unity Biotechnology and the David Sinclair lab entering human clinical trials later this year for senescent cell removal and DNA repair respectively, the development of effective biomarkers to measure how someone is aging and how therapies effect that are a matter of urgency.

Given that there are various causes of aging and that rejuvenation therapies will generally only target one or two of these processes, the first therapies will likely only be partially effective. The aging processes are all interlinked as well so affecting one may effect others, hence there is a need for a comprehensive panel of biomarkers in order for researchers to prove the efficacy of therapies.

Another thing to consider with a therapy such as senescent cell removal is, whilst you can measure how effective it is at removing senescent cells (to a reasonable degree using β-galactosidase etc…) being able to demonstrate the wider benefits of doing so is trickier. So the challenge here is to find a suitable range of biomarkers that can provide a good level of proof that rejuvenation has occurred when using these therapies. This means various measures of functional age and health are required, and these measures should be something the research community as a whole agree upon as being suitable.

If you are religious, or have religious friends worried about the implications of rejuvenation for their beliefs, this article may help.

Preamble: I am an atheist. So I don’t have any God-related issues concerning rejuvenation/living forever. Other people, though, may believe there’s an afterlife waiting for them once they die, or that curing ageing equals playing God. I don’t think these are particularly problematic concerns.

First, if anyone at all, believer or not, wishes to die at any point, I am in no position to object. It’s their life, not mine, and they can do with it whatever they see fit. If you are afraid of never reaching your god because of quasi-immortality, I think you should be free to die the way you wish, be it by ageing or whatever way you prefer (as long as you don’t take others down with you). I think it’d be crazy to terminate your life for this reason, but hey, whatever sinks floats your boat. It’s your choice, and you should be given it. Rejuvenation isn’t about forcing people to never die. It’s about giving them the possibility of living in perfect health for as long as they see fit.

LEAF caught up with Futurist David Wood at the recent International Longevity and Cryopreservation Summit in Madrid to talk about rejuvenation biotechnology.

We recently attended the International Longevity and Cryopreservation Summit in Madrid. LEAF director Elena Milova caught up with futurist David Wood at the summit to ask him about his work and his views on the development of rejuvenation biotechnology.

Continue reading “David Wood – We Should Prepare for the Future Now” »

I’ll be on a panel and also doing an author’s roundtable (The Transhumanist Wager) at FreedomFest in Las Vegas on July 21. It’s one of the largest gatherings of free minds in the world and this year is the 10th anniversary. If you’re there, please say hello! Others are speaking on life extension and AI. Here’s my speaker’s page:

Check out what Zoltan Istvan will be attending at FreedomFest 2017.

The concept of repairing age-related damage to prevent diseases is now mainstream and openly talked about by most acadmics.

Earlier this year the second Scripps Florida Symposium was held and now this open access paper reports on the event. The title of of the event was ‘Advances in Therapeutic Approaches to Extend Healthspan’ and was held on January 22nd–25th, 2017 at The Scripps Research Institute in Jupiter, Florida.

It is once again very refreshing to see that the focus of the researchers here is now firmly on intervening on the various aging processes in order to prevent or treat age-related diseases. Less than a decade ago suggesting addressing the aging processes to treat disease as a preventative form of medicine would have jepordised the chances of funding, or even damaged a researcher’s career prospects. Now the majority of researchers are engaged in exploring the potential of increasing healthspan (the period of life spent free of age-related disease) with the aim of delaying or preventing age-related diseases.

Continue reading “Rejuvenation Biotechnology is now Mainstream Science” »

We teamed up the MMTP last week and did a special longevity live panel on Facebook with Dr. Aubrey de Grey, Dr. Alexandra Stolzing, Dr. Oliver Medvedik and guests. Check it out.

We teamed up with the MMTP for their “How to Promote Longevity?” Live Panel. Dr. Aubrey de Grey, Dr. Alexandra Stolzing and Dr. Oliver Medvedik and guests discuss the latest research and progess in rejuvenation biotechnology.

https://www.youtube.com/watch?v=KoRTTOzkkN0&feature=share

Liz Parish joins the show to discuss her company’s efforts to reverse aging. Her aging trials have been famously conducted on her personally resulting in 20 year reversals on Telomere cell lengths, muscle mass, and other factors. We discuss the real possibility that humans could live to be over 1000 years old in our lifetimes. We also discuss the ethical issues that arise from the flood of new technologies that will soon be on the market.

You can see more about Parrish and her company at BioViva-Science.com

Continue reading “Immortality Our Future? Technology is our Fountain of Youth with Liz Parrish” »

Interview with Dr. Jose Luis Cordeiro at the International Longevity and Cryopreservation Summit in Madrid.

During the recent International Longevity and Cryopreservation Summit in Madrid, LEAF Board member Elena Milova had the opportunity to speak with Dr. Jose Luis Cordeiro new fellow of the World Academy of Art and Science (WAAS) and long-term proponent of innovation technologies in many fields. Jose shared his vision on how public perception of rejuvenation technologies is changing over time and what are the main outcomes of the groundbreaking show he and his team managed to organize.

Continue reading “Dr. Jose Luis Cordeiro – Supporting the development of cryonics and rejuvenation biotechnology” »