Archive for the ‘life extension’ category: Page 445
Nov 2, 2018
Rebel HQ Live: Jiggy Athilingam & Keith Comito
Posted by Elena Milova in category: life extension
Nov 2, 2018
The last 15 hours of the NAD+ Mouse fundraiser and we are only $2431 away from the final goal
Posted by Steve Hill in categories: biotech/medical, life extension
If we can reach our third and final stretch goal and expand the scope of the experiment massively. Could NMN be a true anti-aging drug?
Nov 2, 2018
Choosing Health Early On
Posted by Nicola Bagalà in categories: futurism, life extension
A thought experiment to see whether life extension might contribute to your happiness.
Today, we’re going to engage in a thought experiment. We’re going to imagine a world with some sort of antechamber to life in which you hang around as some sort of disembodied entity before you are born. (Some people actually believe in something like that, but we won’t go there; it’s just a thought experiment.)
The Choice to Be Born
Nov 2, 2018
We are happy to announce Professor Barker as a speaker for the 2019 Undoing Aging Conference
Posted by Michael Greve in categories: biotech/medical, life extension
http://www.undoing-aging.org/news/professor-richard-barker-t…nbrFm8JTxA
Richard is an internationally respected leader in healthcare and life sciences. He says: “I’m focused on accelerating precision medicine technologies to advance our healthy lifespan”.
Nov 1, 2018
NAD+ Mouse New Stretch Goal Announced
Posted by Steve Hill in categories: biotech/medical, life extension
Yesterday, we announced the successful completion of the NAD+ Mouse Project after a great fundraiser, but it seems we are not done yet. The research team at Harvard has announced a new stretch goal for the last two days of the campaign.
A new $75,000 goal is to be the final step, and to support that, Dr. David Sinclair is offering to fund match the next $5000 in donations to the project to help it reach this final goal. So, for the next two days, all donations are worth double.
The final goal will be to add even more comprehensive testing, such as end-of-life pathology (frequency and specificity of neoplasms/tumors/cancer) and MRI diagnostics (body composition, lean-to-fat ratio). This would really allow the researchers to maximize the useful data they collect during the study and help assess any changes to cancer risk, why each animal died, and what age-related diseases were affected by the drug.
Nov 1, 2018
Bioquark Inc. — Eat This, Not That! — Ira Pastor
Posted by Ira S. Pastor in categories: aging, biotech/medical, chemistry, DNA, genetics, health, life extension, neuroscience, science, transhumanism
Oct 31, 2018
Dr. Antonei Csoka at Ending Age-Related Diseases 2018 — Aging as Meta-Disease
Posted by Cathy Miller in categories: biotech/medical, life extension
Good information 💜.
Dr. Antonei Csoka of Howard University discusses the concept of aging as meta-disease and about the hierarchy of some of the Hallmarks of Aging. He also discusses some of the philosophical and metaphysical underpinnings for the goal of overcoming age-related disease.
Continue reading “Dr. Antonei Csoka at Ending Age-Related Diseases 2018 — Aging as Meta-Disease” »
Oct 30, 2018
Journal Club October 2018 — Drug Synergy Slows Aging
Posted by Steve Hill in categories: biotech/medical, life extension
The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan.
SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that dramatic lifespan extension can be achieved by targeting multiple, evolutionarily conserved aging pathways and mechanisms using drug combinations. Using this approach in C. elegans, we were able to slow aging and significantly extend healthy lifespan. To identify the mechanism of these drug synergies, we applied transcriptomics and lipidomics analysis. We found that drug interactions involved the TGF-b pathway and recruited genes related with IGF signaling. daf-2, daf-7, and sbp-1 interact upstream of changes in lipid metabolism, resulting in increased monounsaturated fatty acid content and this is required for healthy lifespan extension. These data suggest that combinations of drugs targeting distinct subsets of the aging gene regulatory network can be leveraged to cause synergistic lifespan benefits.
