Lifeboat Foundation

Research in mice shows limited intakes of one particular essential amino acid can slow the impacts of aging and even lengthen their lifespan.

Scientists are now wondering if these findings could help people improve their longevity and quality of life.

Isoleucine is one of three branched-chain amino acids we use to build proteins in our bodies. It is essential for our survival, but since our cells can’t produce it from scratch, we have to get it from sources like eggs, dairy, soy protein and meats.

Where are the best places to find longevity research? We just updated this list of top anti-aging research journals; any we missed?

Finding quality life-extension research is tough, so we’ve compiled the best anti-aging research journals and resources, all in one place!

Our brains change more rapidly at various times of our lives, as though life’s clock was ticking faster than usual. Childhood, adolescence and very old age are good examples of this.

Yet for much of adulthood, the same clock seems to tick fairly regularly. One lap around the Sun; one year older.

However, there may be a stage of life when the brain’s clock starts speeding up. The brain starts changing without you necessarily noticing it. It may even be caused (partly) by what’s in your blood.

More and more people around the world are taking their chances that science will advance significantly in the future so their preserved, frozen bodies can be revived back to life.

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Welcome back to Virtual Reality James! In this exciting video, we delve into the groundbreaking topic of Japan’s Anti-Aging Vaccine and explore the future of longevity. Join us as we uncover the latest scientific advancements and reveal how this revolutionary vaccine could potentially transform the way we age.

Discover the secrets behind this cutting-edge technology that aims to slow down the aging process and enhance our quality of life. We’ll explore the science behind the vaccine, its potential benefits, and the implications it may have on society as a whole.

Continue reading “Japan’s Anti-Aging Vaccine: The Future of Longevity Revealed” »

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The field of aging research has made significant progress over the last three decades, reaching a stage where we now understand the underlying mechanisms of the aging process. Moreover, the knowledge has broadened to include techniques that quantify aging, decelerate its process, as well as sometimes reverse aging.

To date, twelve hallmarks of aging have been identified; these include reduced mitochondrial function, loss of stem cells, increased cellular senescence, telomere shortening, and impaired protein and energy homeostasis. Biomarkers of aging help to understand age-related changes, track the physiological aging process and predict age-related diseases [1].

Longevity. Technology: Biological information is stored in two main ways, the genomes consisting of nucleic acids, and the epigenome, consisting of chemical modifications to the DNA as well as histone proteins. However, biological information can be lost over time as well as disrupted due to cell damage. How can this loss be overcome? In the 1940s, American mathematician and communications engineer Claude Shannon came up with a neat solution to prevent the loss of information in communications, introducing an ‘observer’ that would help to ensure that the original information survives and is transmitted [2]. Can these ideas be applied to aging?

Alpha ketoglutarate, or AKG, has long been used as a dietary supplement in the bodybuilding world.

By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that a branch of glycolysis, the serine biosynthesis pathway (SBP), is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSC activation and expansion of myogenic progenitors through production of the metabolite α-ketoglutarate (α-KG) and α-KG-generated glutamine. Psat1 ablation resulted in defective expansion of MuSCs and impaired regeneration. Psat1, α-KG, and glutamine were reduced in MuSCs of old mice. α-KG or glutamine re-established appropriate muscle regeneration of adult conditional Psat1 ^-/- mice and of old mice. These findings contribute insights into the metabolic role of Psat1 during muscle regeneration and suggest α-KG and glutamine as potential therapeutic interventions to ameliorate muscle regeneration during aging.

Keywords: aging; glutamine; ketoglutarate; muscle regeneration; muscle stem cells.

Continue reading “Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration” »

Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and the Bloomberg~Kimmel Institute for Cancer Immunotherapy.

The study, published online Feb. 8 in Cancer Research, provides clues as to why pancreatic cancer is more common and aggressive in older people. It may also help scientists develop new therapeutic approaches for this difficult-to-treat cancer. The study showed that aging alters fibroblasts in ways that enable them to promote pancreatic cancer tumor growth.

“Older fibroblasts release proteins that directly affect pancreatic cancer cells and ultimately lead to the growth and spread of pancreatic cancer tumors,” says the study’s lead author, Daniel Zabransky, M.D., Ph.D., assistant professor of oncology at the Johns Hopkins University School of Medicine. “The younger fibroblasts did not have these capabilities. We think this is a key reason why we see pancreatic cancer more commonly in older patients.”