Lifeboat Foundation

Given the chance, there are very few of us who wouldn’t want to slow down the aging process. Chasing that fountain of youth is a major branch of medical science at the moment, and a hardy little worm known as C. elegans is probably the most prolific test subject. Now, a team at Scripps Research has found that blocking a particular enzyme can extend the lifespan of these worms by almost half again.

Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging.

Senescent cells and the SASP

As we get older, an increasing number of our cells enter into a state known as senescence. They cease dividing and supporting the tissues and organs of which they are part and, instead, secrete a range of harmful chemical signals. This cocktail of harmful signals is known as the senescence-associated secretory phenotype (SASP).

Continue reading “A New Database for Senescent Cells” »

Clinical trials to remove senescent cells have now begun.

Eric Kilhstrom (Director of Aging Analytics Agency and former Interim Director of the £98 million Healthy Ageing Industrial Strategy Challenge Fund) is interviewed about the agency’s recent “Longevity Industry in Israel Landscape Overview 2019” report.

New report shows that Israel’s academic and business ecosystem is the optimal base for an internationally recognized longevity industry hub.

Continue reading “Israel fast becoming world hub of aging industry” »

We submitted the Longevity Peace Prize, worth $5 million dollars to be awarded to any longevity activist(s) in the next 5 years who can get a major world government or the UN to declare “aging a disease” as a policy and to help reverse regulatory hurdles on life extension research. Hopefully, this early version of a prize may one day become reality. https://xprize.org/

April is gone, and before we move on to May, let’s take a look back at the highlights of last month in the rejuvenation world.

LEAF News

Continue reading “Rejuvenation Roundup April 2019” »

undoing-aging.org/…/judy-campisi-presenting-at-undoing-agin…

More info on Forever Healthy: forever-healthy.org

The findings, published in the journal Nature Medicine, showcase a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome. This treatment provides an important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy. The researchers hope to translate this therapy to humans to potentially provide a cure for progeria as well as possibly slowing down the aging process to delay the onset of age-related diseases in everyone.

Link to paper: https://www.nature.com/articles/s41591-019-0343-4

Abstract.

Continue reading “The April Journal Club will be discussing the recent paper from the Salk Institute” »