Lifeboat Foundation

“Demonstrate That Top Financial and Tech Corporations Are Committed to Longevity”

This week two Landmark International Longevity Summits in London attracted the attention of scientists, government officials, major financial corporations, insurance companies, investment banks, and technology companies from around the world. The Landmark AI for Longevity Summit and the First International Longevity Policy and Governance Summit at King’s College London are expected to become the world-leading forums for the Longevity Industry.

Some important news out today, and we hope to have an official announcement in the next 24 hours or so as my team makes final preparations. Thank you for your support!

Zoltan Istvan, a leader of the transhumanist movement to merge humans with technology, is challenging Trump with a plan for America that’s beyond radical.

A new study is suggesting a metabolite produced by gut microbes could increase neuron production in the brain, improve intestinal function, and ultimately slow the aging process. Across several compelling mouse experiments the research found the negative effects of aging could be counteracted by enhanced microbial production of a molecule called butyrate.

Investigating the effect of the gut microbiome on aging, the new research first performed gut microbiome transplants between old and young mice. Using fecal transplants, young germ-free mice were colonized with the gut microbiota of older mice. The results were somewhat unexpected as the younger mice colonized with the older microbiomes displayed increased neurogenesis, a process whereby new neurons are produced in the brain.

“We’ve found that microbes collected from an old mouse have the capacity to support neural growth in a younger mouse,” explains Sven Pettersson, lead on the research team from Nanyang Technological University in Singapore. “This is a surprising and very interesting observation…”

Award Program Honors the Achievement.

MOUNTAIN VIEW November 11, 2019 — Sens Research Foundation has been selected for the 2019 Best of Mountain View Award in the Medical Laboratory category by the Mountain View Award Program.

Each year, the Mountain View Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Mountain View area a great place to live, work and play.

The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

• Immediate Communication
• Published: 18 November 2019

• Valentina Cinquina ¹,
• Daniela Calvigioni ¹,
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Ira Pastor ideaXme exponential health ambassador interviews Mr. Dennis Kowalski, Cryonics Institute President, EMT-paramedic, certified in advanced cardiac life support (ACLS), advanced pediatric life support (PALS), a CPR Instructor for the American Heart Association, and a fire fighter!

Ira Pastor comments: Cryonics is defined as the extremely low-temperature freezing (or vitrification — converting into glass or a glass-like substance) usually at −196 °C or −320.8 °F or 77.1 K, and storage of a human body or part of a human body, with the hope that resurrection may be possible in the future.

Continue reading “Cryonics: Ambulance To The Future?” »

How well will they do, and is life extension accurately portrayed in popular fiction? Let’s find out!