Lifeboat Foundation

7-Ketocholesterol is a harmful oxidized byproduct of cholesterol, it is highly toxic with no redeeming qualities and serves no purpose in our bodies aside from allowing heart disease to develop. Check out Underdog Pharma’s recent review at Science Direct to learn more!

Oxidative stress has long been causatively implicated in the aging process [219,220]. As described in section 2, 7KC is the most common stable product of a reaction between cholesterol and a free radical. This is a vicious cycle as 7KC also leads to increased free radical production and release, seemingly by plasma membrane permeabilization. As discussed above, mitochondrial dysfunction and free-radical formation are also strongly implicated in the aging process and so while the precise mechanistic links between mitochondria, 7KC, and aging are still being elucidated they seem likely to be intertwined.

Is 7KC a biomarker of aging? As discussed in section 4, 7KC accumulation is directly implicated in many diseases of aging, including atherosclerosis, heart failure, AMD, NAFLD, and AD. It is thus reasonable to hypothesize that when otherwise unrelated diseases of aging share a common cause, that this cause is likely to be a part of the biological aging process. 7KC is known to accumulate in phagocytic cells such as macrophages (promoting the formation of foam cells), RPE cells, and microglia. It has also been suggested that c. elegans subjected to 7KC could be a good model of 7KC-dependent aging [221]. As 7KC is broadly toxic, and most cells seem to have difficulty metabolizing it, it may be that, with age, 7KC is bioaccumulating and impairing functional activity of the cells and tissue.

Continue reading “7-Ketocholesterol in disease and aging” »

New research suggests that senolytic drugs, which remove harmful senescent cells that accumulate during aging, may be an effective therapy for glaucoma, a common age-related condition that leads to loss of vision.

In the short term, inflammation serves a useful purpose, as it helps to spur the repair and regeneration of tissue and rallies the immune system to defend against marauding invaders.

However, the chronic, smoldering, low-grade inflammation that occurs during aging can be incredibly harmful. The sources of this “inflammaging,” as some researchers describe it, include (but are not limited to) dysfunctional immune cells, cell debris, disruption to the gut microbiome, and senescent cells. Today, we are concerned about the latter after the release of a new study focusing on senescent cells and glaucoma [1].

Cardiorespiratory exercise—walking briskly, running, biking and just about any other exercise that gets your heart pumping—is good for your body, but can it also slow cognitive changes in your brain?

A study in Mayo Clinic Proceedings from the German Center for Neurodegenerative Diseases provides new evidence of an association between cardiorespiratory fitness and brain health, particularly in gray matter and total brain volume—regions of the brain involved with cognitive decline and aging.

Brain tissue is made up of gray matter and filaments called white matter that extend from the gray matter cells. The volume of gray matter appears to correlate with various skills and cognitive abilities. The researchers found that increases in peak oxygen uptake are strongly associated with increased gray matter volume.

Nothing lasts forever. Humans, planets, stars, galaxies, maybe even the Universe itself, everything has an expiration date. But things in the quantum realm don’t always follow the rules. Scientists have found that quasiparticles in quantum systems could be effectively immortal.

That doesn’t mean they don’t decay, which is reassuring. But once these quasiparticles have decayed, they are able to reorganise themselves back into existence, possibly ad infinitum.

This seemingly flies right in the face of the second law of thermodynamics, which asserts that entropy in an isolated system can only move in an increasing direction: things can only break down, not build back up again.

This technology may one day be used to revive patient suspended in cryonics.

A new way to warm up frozen tissue using tiny vibrating particles could one day help with the problem of organ shortages.

We know how to cool organs to cryogenic temperatures, which is usually below 320 degrees Fahrenheit. But the organs can’t be stored for long — sometimes only four hours for heart and lungs — because they get damaged when you try to warm them up. As a result, more than 60 percent of donor hearts and lungs aren’t transplanted. In a study published today in Science Translational Medicine, scientists used nanoparticles to warm up frozen tissue quickly and without damaging the organs. Within a decade, this could lead to being able to store entire organs in organ banks for a long period of time, the authors say.

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VITAMINS-Nutrients have long been described as healers-Life extending amino acids-chemicals… As has been done in the past holds true presently. There are trained professionals who for one reason or another attack the vitamin industry.

(Many claiming that vitamins do nothing and are washed from the body???)

How then did niacin extraction and synthesizing and being put into foods help end many sicknesses??? Yes Niacin is listed as a vitamin and a medicine…

Continue reading “Experts: Oversight needed for safety, efficacy of nutritional supplements” »

The great Elizabeth Parrish on ageing the most sinister disease on earth… I hate it when words are used to make aging sound like a normal sickness or a great sickness, Such as grandest??? Or most Important disease??? The decomposer disease that Woman-man has called natural aging all these years has been in reality a clandestine plague so complicated yet so easily seen by the naked eye if certain scholars-textbooks do not get in the way…

Aging is The Eukaryotic Cellular pandemic plague AEWR has named the Senesonic-Sensonic plague. A disease that causes all of our cells to age nearly at the same rate causing our cells to have to regenerate the day long or the body drops.

Continue reading “‘We’re working on a cure for the grandest disease on the planet: biological ageing’” »