Lifeboat Foundation

In a surprising study, Oregon State University researchers found that no matter how much stress they placed on mice from either a high-fat diet or strenuous exercise, the animals’ mitochondria were able to adapt and continue their normal processes.

The findings could have major implications for the study of diseases like diabetes, Parkinson’s and Alzheimer’s, all of which are associated with an impairment in the breaking-down and clearance of damaged mitochondria.

Mitochondria are the structures that house cellular respiration, the process used to turn nutrients into energy. Dysfunction in mitochondria may lead to lower energy production, greater inflammation and tissue damage. Yet as central as mitochondria are to living organisms, scientists still don’t know exactly what keeps them healthy—or makes them unhealthy.

You may have noticed that the LEAF website is no longer there! Don’t panic, we will explain everything.

We have come a long way

Back in late 2016, we launched the LEAF website as a companion site to Lifespan.io, our research fundraising platform. Since those first steps, the site has become increasingly popular and has enjoyed rapid growth during this time.

Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

Osteoarthritis is one of the most common ailments of an aging population, but there aren’t many treatment options besides taking pain killers or getting a full joint replacement. Now, researchers at the Salk Institute have found that a combination of two experimental drugs appears to reverse the symptoms of the disorder, with successful tests conducted in rats and in human cells in the lab.

As we age, our bodies gradually lose the ability to repair damage as fast as it needs to. That means that tissues subjected to high-intensity long-term use, such as cartilage in joints, are especially prone to wearing out. That manifests itself in the common condition of osteoarthritis, resulting in pain when that joint moves.

In the past, two molecules have been identified as having decent potential for treating the disease – alpha-KLOTHO (αKLOTHO) and TGF beta receptor 2 (TGFβR2). Previous tests only showed moderate success, so the researchers on the new study decided to see if they fared any better when used together.

A burn that is over 25% of the human body area can be life threatening. However a burn that is only 1 percent but on a visible area of the body can be life-worsening. That is why advancements in the area of wound care and burns treatment are so important from patient perspective. Being a doctor of the future will include having a point-of-care device such as a 3D-Bioprinter that will scan the lesions in dept and width and print a gel imbued with cells and prolo-factors.

Forgive me my conservatism… we already have such clinics that are on the clinical trials for such treatments.

Read more in the article. Stay tuned for more topics through the Academy blog. Gain more knowledge in Regenerative Medicine and practical experience with biologics through the Annual Congress — Global Regenerative Congress 18–20 September 2020 in Dubai. Registrations are open: www.grc2020dubai.com

Continue reading “Handheld bioprinter for treating burns at the point-of-care” »

As the number of older Americans begins to rise, director Eric Verdin is leading his organization’s efforts to combat aging.

O.o probs alien o.o circa 2013.

Remember when encyclopaedias were books, and not just websites? You’d have a shelf full of information, packaged into entries, and then into separate volumes. Your genome is organised in a similar way. Your DNA is packaged into large volumes called chromosomes. There are 23 pairs of them, each of which contains a long string of genes. And just as encyclopaedia books are bound in sturdy covers to prevent the pages within from fraying, so too are your chromosomes capped by protective structures called telomeres.

That’s basically how it works in any animal or plant or fungus. The number of chromosomes might vary a lot—fruit flies have 8 while dogs have 78—but the basic organisation is the same.

Continue reading “You Have 46 Chromosomes. This Pond Creature Has 15,600” »