Lifeboat Foundation

Centenarians have become the fastest-growing demographic group in the world, with numbers approximately doubling every 10 years since the 1970s.

Many researchers have sought out the factors and contributors that determine a long and healthy life. The dissolution isn’t new either, with Plato and Aristotle writing about the ageing process over 2,300 years ago.

Understanding what is behind living a longer life involves unravelling the complex interplay of genetic predisposition and lifestyle factors and how they interact.

Using a dimensionality reduction approach, Fong et al. generated a clinical aging clock (PCAge) that delineates healthy and unhealthy aging trajectories. They provide a streamlined version (LinAge) that maintains predictive power, and they demonstrate how the clock can be tailored to available data using the CALERIE study.

Bringing together the global cryonics field including leaders, researchers, and members.

In a much-anticipated debate, prominent aging researchers Aubrey de Grey and Peter Fedichev presented their competing, but also overlapping, theories.

When the non-profits Foresight Institute, Open Longevity, and Say Forever had the idea to hold debates on the best strategy to defeat aging, there was little question about whom they should invite first. Aubrey de Grey, head of LEV Foundation and one of the faces of the longevity field, and Peter Fedichev, CEO of Gero and a rising star in the same field, already had an impromptu debate last year in Zuzalu, the longevity/crypto/AI-themed pop-up city in Montenegro. I had the honor to witness that clash of titans, which kept a small but dedicated crowd on its toes for more than two hours.

The impromptu debate in Zuzalu. Photo: Arkadi Mazin.

I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell.

Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in ∼90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves noncanonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.

This also an amazing supplement that also exists in all foods called nad plus that stops age related symptoms.

Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here, the authors show that low-dose nicotine promotes SIRT1 deacetylation of NAMPT and enhanced NAMPT activity which boosts NAD generation and improves age related symptoms.

Though hardly conclusive, this study strongly suggests that boosting NAD+ levels in humans could have incredible health benefits.

That’s where Basis comes in.

Created by Elysium Health, Basis is a proprietary formulation of crystalline nicotinamide riboside and pterostilbene, which the human body converts into NAD+. In a double-blind, randomized, placebo-controlled clinical trial, it was demonstrated that, on average, Basis increases NAD+ levels by 40 percent. These elevated NAD+ levels won’t necessarily stop the aging process. But they will certainly maximize cellular health, boost energy, and support healthy sleep. This in turn should allow people who are in good health to maintain it longer, and thus age better.

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Johnson’s latest foray into anti-aging science took him to the Roatan, an island off the coast of Honduras, where he received follistatin gene therapy in the form of two injections. The entrepreneur says that he spent $20,000 on reversible gene therapy developed by the method development company Minicircle.