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Archive for the ‘life extension’ category: Page 297

Jul 10, 2020

Scientists may have found one path to a longer life

Posted by in categories: biotech/medical, life extension

Scientists at USC Dornsife College of Letters, Arts and Sciences may have found the beginnings of a path toward increasing human lifespan.

The research, published July 10 by the Journal of Gerontology: Biological Sciences, shows the drug can extend the lives of two very different species used in , suggesting the findings may apply to other species, including human beings.

Jul 9, 2020

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis

Posted by in categories: biotech/medical, life extension

Reprogramming of differentiated cells into induced pluripotent stem cells has been recently achieved in vivo in mice. Telomeres are essential for chromosomal stability and determine organismal life span as well as cancer growth. Here, we study whether tissue dedifferentiation induced by in vivo reprogramming involves changes at telomeres. We find telomerase-dependent telomere elongation in the reprogrammed areas. Notably, we found highly upregulated expression of the TRF1 telomere protein in the reprogrammed areas, which was independent of telomere length. Moreover, TRF1 inhibition reduced in vivo reprogramming efficiency. Importantly, we extend the finding of TRF1 upregulation to pathological tissue dedifferentiation associated with neoplasias, in particular during pancreatic acinar-to-ductal metaplasia, a process that involves transdifferentiation of adult acinar cells into ductal-like cells due to K–Ras oncogene expression. These findings place telomeres as important players in cellular plasticity both during in vivo reprogramming and in pathological conditions associated with increased plasticity, such as cancer.

Keywords: in vivo reprogramming, telomeres, stem cells, TRF1, tumorigenesis, cellular plasticity, cancer, transdifferentiation, ADM, regeneration.

Reprogramming into full pluripotency has been achieved in vivo in the context of mouse tissues (Abad et al., 2013). Thus, induction of the reprogramming factors in transgenic mice (so-called reprogrammable mice) results in reprogramming events marked by the expression of the pluripotency factor NANOG in multiple organs, tissue dedifferentiation, and teratoma formation. Therefore, these mice could be useful for a deeper understanding of the molecular mechanisms that govern tissue dedifferentiation in vivo. Interestingly, mammalian cell reprogramming can also occur spontaneously during regeneration after injury or damage conditions (Yanger et al., 2013). Differentiated cells can be converted in vivo into another cell type and also into functional multipotent stem-like cells (Tata et al., 2013). This capacity of somatic cells to dedifferentiate into stem-like cells in vivo may have a pivotal role in physiological tissue regeneration or during tumorigenesis.

Jul 9, 2020

Brain benefits of exercise can be gained with a single protein

Posted by in categories: biotech/medical, life extension, neuroscience

A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research. The findings could lead to new therapies to confer the neuroprotective effects of physical activity on people who are unable to exercise due to physical limitations.

Exercise is one of the best-studied and most powerful ways of protecting the from and has been shown to improve cognition in individuals at risk of neurodegenerative disease such as Alzheimer’s disease and frontotemporal dementia —even those with rare gene variants that inevitably lead to dementia.

Continue reading “Brain benefits of exercise can be gained with a single protein” »

Jul 7, 2020

More Humanin Increases Chances for Healthier Living to 100

Posted by in categories: biotech/medical, life extension

Aging/longevity/heathspan fans!!


Higher levels of humanin, a peptide encoded in the small genome of the mitochondria, in the body is linked to longer lifespans and better health.

Aging Journal – The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Continue reading “More Humanin Increases Chances for Healthier Living to 100” »

Jul 7, 2020

Among older adults, statin use tied to decreased risk of death

Posted by in categories: biotech/medical, life extension, neuroscience

Study after study has shown that statins can prevent heart attacks, strokes and death in middle-aged adults. But in 28 major clinical trials of statins, only 2 percent of participants have been 75 years or older. This means that even though older adults are at greater risk of heart disease and death, there is scant data on whether statins should be prescribed for them.

A new study led by investigators from Brigham and Women’s Hospital and VA Boston Healthcare System leverages national data from the U.S. Veterans Health Administration Services and Centers for Medicare & Medicaid Services to shed new light on the role statins may play for older adults who have not yet experienced a , stroke or other cardiovascular event. In their retrospective analysis, the researchers found that the risk of dying from any cause was lower by 25 percent among veterans who were using statins compared to those who were not treated with statins. The risk of dying from a cardiovascular event, such as a heart attack or stroke, was lower by 20 percent. The team’s results are published in JAMA.

“Based on these data, age is not a reason to not prescribe statins,” said lead and corresponding author Ariela Orkaby, MD, MPH, a physician scientist at VA Boston Health Care System and in the Division of Aging at the Brigham. “Statins are commonly studied and prescribed for middle-aged adults but understudied in people over age 75. One of the most remarkable things about our results is that we found the benefit of statins held true regardless of whether a person was older or younger or had a condition such as dementia.”

Jul 6, 2020

How the body regulates scar tissue growth after heart attacks

Posted by in categories: biotech/medical, life extension

Very interesting.


New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.

Once formed, remains for life, reducing the heart’s ability to pump blood and adding strain to the remaining heart muscle. People who develop larger scars have a higher risk of heart rhythm problems, heart failure and sudden cardiac death.

Continue reading “How the body regulates scar tissue growth after heart attacks” »

Jul 6, 2020

Male fruit flies’ decline in fertility with age is not only driven by changes in sperm

Posted by in categories: biotech/medical, genetics, life extension

Infertility is one of the most striking effects of aging. The impact of aging on females’ fertility is more severe and much better understood, but it also affects males. Male reproductive aging is less researched, but of those studies that do address it, most focus on sperm. However, ejaculate contains more than just sperm. Proteins in the seminal fluid are important for fertility, and in many animals, they have a dramatic effect on female physiology and behavior. Little is currently known about the impact of male aging on these proteins, and whether any changes contribute to poorer ejaculates in older males.

To resolve these questions, researchers at the University of Oxford’s Department of Zoology conducted experiments in a model organism, the fruit fly, Drosophila melanogaster. This species typically lives for less than five weeks, which means that researchers can very rapidly measure the impact of age on male fertility, and their and seminal fluid proteins. This species is also highly amenable to genetic studies, which allowed the researchers to genetically manipulate , to see how this impacted the decline in fertility with age.

Published this week in PNAS are their results which show that both sperm and quality and quantity decline with male age, making distinct contributions to declining reproductive performance in older males. However, the relative impacts on sperm and seminal fluid often differ, leading to mismatches between ejaculate components. Despite these differences, experimental extension of male lifespan improved overall ejaculate performance in later life, suggesting that such interventions can delay both male reproductive aging and death.

Jul 5, 2020

Posthuman Politics and Artificial-Death

Posted by in category: life extension

A better deal than any supernaturalist religion can offer; that seems to me what Julian Huxley intended. Some relief from fear of death. Morality self judged and perhaps situational – but not ethical codes forced on you by an imaginary invisible bullying tyrant(s) or a human calling upon His name…

A lot – possibly most- individuals on trans/ singul/ posthuman lists are drawn to radical futurism for specific reasons of extending life and attaining immortality (continuation of awareness) after physical death by technology. Different groups are working on different projects, but posthuman.org is concentrating on MVT analog circuits with Zenet interface. This is much less ambitious than approaches involving whole brain/ personality/ memory preservation, since there is only need to retain signals relating to game decision making. But who wants to be particularly aware of being dead?

Jul 5, 2020

Age-related heart disease linked to gut bacteria metabolite

Posted by in categories: biotech/medical, chemistry, food, life extension

New research from the University of Colorado Boulder has offered some of the clearest evidence to date showing how the gut microbiome produces a metabolite that, over time, contributes to age-related declines in cardiovascular health.

High blood levels of trimethylamine-N-Oxide (TMAO), a metabolic byproduct of digestion, have been strongly linked to negative cardiovascular health. When one eats red meat, eggs or other animal proteins, certain types of gut bacteria feed on chemicals in those foods and produce TMA, or trimethylamine, which is then turned into TMAO in the liver.

A number of studies have linked TMAO to heart disease, however, until now it hasn’t been clear exactly how this metabolite causes cardiovascular damage. A robust new study, published in the journal Hypertension, is offering one of the first thorough mechanistic investigations illustrating how TMAO damages the cardiovascular system.

Jul 4, 2020

Common Sense by Thomas Paine, with Life Extension Correlations

Posted by in categories: government, health, life extension, philosophy, scientific freedom, strategy

Before the Revolutionary war in North America, a movement in favor of establishing independence paved the way. Common Sense, written by the political activist and philosopher Thomas Paine, became a central part of it. In this paper I go over some of its points while making correlations with the movement for indefinite life extension.

The people of America’s 13 colonies weren’t in agreement on how to move forward with their disputes with Great Britain. Like Thomas Paine wrote, “The mind of the multitude is left at random, and seeing no fixed object before them, they pursue such as fancy or opinion starts.” Common Sense fixed the object of independence, rather than reconciliation with tyranny, in enough minds to help make it happen.

True freedom is about much more than things like the ability to sail the open seas or be independent from the authority of kings – it is about access to all constructive opportunities, of which there may be an infinite number, and to which there are still innumerable barriers. Every day asks us whether we want to put in work to break more of the barriers around us, and every day we either reconcile with the conventions of laissezfaire or continue the struggle for freedom.

Movements have broken many bonds over the decades and centuries. What was once a world overrun with crushing suppressions is now manageable and improving in many countries on numerous fronts. We need that “fixed object” that Paine was talking about so we can open the frontiers of industrialized peoples next most pressing freedom. That object is time, the walls of defined lifespans must come down. Nothing is more absolutely enslaving than <125 year death sentences for all, and the times are ripe and ready to take it on. The world works with and engineers biology in many ways now and gets better at it faster as the toolbox of biotechnology continues to deepen. Biological mastery is in the cards if we play them.

Paine wrote, ”O ye that love mankind! Ye that dare oppose, not only the tyranny, but the tyrant, stand forth! Every spot of the old world is overrun with oppression. Freedom hath been hunted round the globe. Asia, and Africa, have long expelled her—Europe regards her like a stranger, and England hath given her warning to depart. O! receive the fugitive, and prepare in time an asylum for mankind.” In that style I would write, “O ye that love life! Ye that dare oppose, not only the symptoms of mortal afflictions, but the roots, stand forth! Every spot of the world is overrun with death. Life hath been hunted round the globe. Tradition and religion have long expelled her—politics regards her like a stranger, and trend setters have given her warning to depart. O! receive the fugitive, and prepare in time an asylum for this survivors blood that fights on through us.”

How many injustices should we accept? How much lack of freedom should we endure? ”There are injuries which nature cannot forgive; she would cease to be nature if she did. […] The robber, and the murderer, would often escape unpunished, did not the injuries which our tempers sustain, provoke us into justice.” I often say that anger for death is there for the same reason that pain is there when touching a hot stove — it is your body prompting you to take corrective measures to end the pain. We ought endure such misfortunes when we must and take action against them when we can.

The time for life extension is now because the tools and insights are here, and also because as Paine says, “When we are planning for posterity, we ought to remember, that virtue is not hereditary.” You know that the people in your life deserve to live, you understand the importance of working to get this done now, but our grandchildren might not. Humanity cannot afford to pass the buck off into the darkness. I may believe that posterity will be roughly as virtuous as us, but I’m not a prophet. Dark times tend to sweep in on their own schedules.

It is our duty to get this job done. “[N]othing can settle our affairs so expeditiously as an open and determined declaration for independance.” The Declaration of Independence was written after Common Sense, mainly by Thomas Jefferson. A life extension version of it might look something like this:


Declaration of Independence from Death

We hold this truth to be self-evident, that all people are created equal, that they are endowed by life with certain unalienable rights, that chief among them is life itself, that is, freedom from incurring the injustice of a defined lifespan. To secure this right, science is practiced among people, deriving its just power from the purest form of the pursuit for answers, for the lifting of the veils of ignorance that hold us back from true freedom. Whenever anything becomes destructive of this end, it is the right of the people to alter or abolish it, and to institute new practices, laying its foundation on principles and organizing its power in such form, as to them shall seem most likely to effect their survival. The history of death is a history of repeated horrors and atrocities. Let the facts be submitted to a candid world.

Every person who dies misses out on what very well may be an infinity of incredible wonders and opportunities. This is stiflingly enormous opportunity cost. People lose their freedom, memories, goals, thoughts, themselves; others lose them; all of humanity and the universe loses them, and nothing in the universe compares to a human. The all-around suffering that death causes to the individuals it kills and the people around them is staggering and endlessly traumatic, causing stress and damage on countless levels of every part of life and society. The death process is degrading and undignified, humiliating people for decades as it reduces them to feebleness, senility and dust. Death deprives people of the ability to know what is going on in this mysterious dimension we all find ourselves in here, what we ultimately are and why we are here. It steals away our chance to know what marvels and wonders exist in the expanses of the great unknown, our ability to experience pleasures we haven’t yet, our ability to know what it’s like to experience the fulfillment of all of our goals, and the chance to work for and live in an existence of negligible or perhaps even non-existent fallacy.

We, the freedom loving members of humanity, from all around the globe, of all cultures and creeds, solemnly declare, that we are, and of right ought to be free from death in the form of defined lifespans. To this end we mutually pledge to each other our fortunes and our sacred honor.



The customs of conventions, our current mainstream traditions, are against us, and will be so, until, by a thorough awakening for independence from death, our oldest and most sacred right, takes its rightful and long overdue place among the ranks of other indispensable rights. “The custom of all courts is against us, and will be so, until, by an independance, we take rank with other nations.”

“Wherefore, if they have not virtue enough to be Whigs, they ought to have prudence enough to wish for Independance.” People do not need to want to live for thousands of years in order to want independence from death, they need only want their own freedom to choose what course they may, and the same for their friends and families. Some people don’t want to be forced to live for thousands of years, and some people don’t want to be forced to die before the age of 125. Currently, however, only the people who might choose to die at the age of 50 have the freedom to make that choice. With unlimited lifespans, we can all be free. This is about eradicating deaths tyranny, not death, in the same way that the American revolutionaries worked to break the stranglehold of tyranny that Great Britain held over them, not stop every slight and fight they might have post-independence.

“We fight neither for revenge nor conquest; […] we are not insulting the world with our fleets and armies, nor ravaging the globe for plunder.” Our war is even more dignified. It is removal of a tyranny and the installation of one of the greatest freedoms of all, all without a shedding of blood.

“[L]et a crown be placed thereon, by which the world may know, that so far as we approve of monarchy, that in America the law is king. For as in absolute governments the King is law, so in free countries the law ought to be King; and there ought to be no other.” The ‘law as King’ is superior to ‘humans as Kings’ because people collectively form laws with some amount of oversight of each other’s input. “Law” as the foundation, however, can still tend to be quite arbitrary. Life is what rules us, living, the chance to do people things in a universe of endless opportunities. Let life wear the crown and guide us along our path to true freedom. “The cause of America is in a great measure the cause of all mankind.” The cause of expanding our frontiers and abilities, of expanding life, is in great measure the greatest cause of them all.