Lifeboat Foundation

Aging is the biggest risk factor for perturbation of the nervous system, even in the absence of distinct disease or trauma. For yet unknown reasons, the impulse conducting, myelinated projections and synaptic connections between nerve cells are especially vulnerable to aging-related degeneration. These pathological alterations often manifest as cognitive, sensory, and motor decline in older adults and represent a serious socio-economic challenge.

Malactivation leads to damage

Scientists have long assumed that inflammation plays an important role in this process. Mal-or overactivation of distinct cells belonging to the innate immune system—the microglia—appears to promote damage of nerve fibers and synapses in the aging central nervous system (CNS). In a recent project, scientists of the University Hospital Würzburg have now discovered an important role of the adaptive immune system.

Hey guys — you might like this interview I did with Brent Nally (CEO — Longevity Plan) about why humans can and should strive towards biological immortality. Very grateful for any subs to support the channel!

I interview Brent Nally, host of Lifespan News and CEO/co-founder of Longevity Plan, about the longevity movement and why he believes humans can and should strive for biological immortality. Covers scientific progress, the evolving longevity movement, why some oppose radical life extension and a brief section on Bitcoin.

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As founder of Longevity Vision Fund, I am often asked about the most promising life extension breakthroughs, from early cancer diagnostics to human avatars and everything in between. The simple answer is that there are many — but that’s probably not the kind of answer you were looking for!

Instead, let’s look at the latest longevity breakthroughs working on each of the five major levels of biological organization (cell, tissue, organ, organ system and organism) and what they each aim to accomplish.

In a study at The University of Alabama, aging fruit flies died faster than younger flies from a viral infection because of different genetic responses, lowering the older flies’ tolerance to the infection.

The findings published recently in G3: Genes, Genomes, Genetics add to the understanding of innate immunity, the first line of defense against infections, which is not fully understood in humans, and prove the fruit fly, Drosophila, is a good candidate for aging immunity studies that could lead to advancements in treating viral infections in older humans.

“We are living in times where there is a substantial increase in aging populations, and we know there is a decline of immune function in humans as we age,” said Dr. Stanislava Chtarbanova, UA assistant professor of biological sciences whose lab led the study. “This is the first study to use the fly for investigating age-dependent, anti-viral responses. Our lab can leverage this genetic model to study the molecular mechanisms underlying aging immunity.”

The study is part of an effort by entrepreneurs and scientists, dreamers and schemers, to demonstrate aging is not inevitable.

Can low-carb diets like Keto help you live longer? I spent way too much time reading research papers and the answer seems to be…maybe.

Affiliate Disclaimer: Longevity Advice is reader-supported. When you buy something using links on our site, we may earn a few bucks.

I love bacon.

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Paper references for Levine’s Phenotypic Age calculator and aging.ai:

An epigenetic biomarker of aging for lifespan and healthspan:
https://pubmed.ncbi.nlm.nih.gov/29676998/

Continue reading “Quantifying Biological Age: Blood Test #2 in 2021” »

Aging | doi:10.18632/aging.202188. Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati.

Emmy award winning television commentator, radio personality, and newspaper columnist, juan williams, talking about inter-generational dynamics, ageism, and aging in america.

Progress, Potential, And Possibilities has the honor of being joined today by Emmy Award winning Television Commentator, Radio Personality, and Newspaper Columnist, Mr. Juan Williams.

Continue reading “Juan Williams — Emmy Award Winning Television Commentator, Radio Personality, Newspaper Columnist” »