Lifeboat Foundation

TOKYO — Centenarians have unique gut bacteria that enables them to live to a ripe old age, according to new research. Scientists in Japan say this unique gut makeup fuels bile acids that protect against disease.

The discovery could lead to yogurts and other probiotic foods that increase longevity.

“In people over the age of 100, an enrichment in a distinct set of gut microbes generate unique bile acids,” says lead author Professor Kenya Honda of Keio University in a statement per South West News Service. “They might inhibit the growth of pathogens.”

Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control processes such as signal transduction and metabolism. Prof. Dr. David Vilchez and his colleagues at the CECAD Cluster of Excellence for Aging Research at the University of Cologne performed a comprehensive quantitative analysis of ubiquitin signatures during aging in the model organism Caenorhabditis elegans, a nematode worm broadly used for aging research. This method—called ubiquitin proteomics—measures all changes in ubiquitination of proteins in the cell.

The resulting data provide site-specific information and define quantitative changes in ubiquitin changes across all proteins in a cell during aging. A comparison with the total protein content of a cell (proteome) showed which changes have functional consequences in protein turnover and actual protein content during aging. The scientists thus discovered new regulators of lifespan and provide a comprehensive dataset that helps to understand aging and longevity. The article, “Rewiring of the ubiquitinated proteome determines aging in C. elegans,” has now been published in Nature.

“Our study of ubiquitin changes led us to a number of exciting conclusions with important insights for understanding the aging process,” said Dr. Seda Koyuncu, lead author of the study. “We discovered that aging leads to changes in the ubiquitination of thousands of proteins in the cell, whereas longevity measures such as reduced food intake and reduced insulin signaling prevent these changes.” Specifically, the researchers found that aging causes a general loss of ubiquitination. This is caused by the enzymes that remove ubiquitin from proteins become more active during aging. Normally, ubiquitinated proteins are recognized and destroyed by the proteasome, the cell’s garbage truck. The scientists showed that the longevity of organisms is determined by age-related changes in the degradation of structural and regulatory proteins by the proteasome.

With around two weeks still remaining in its crowdfunding campaign, Buck Institute incubated start-up Gerostate Alpha has cruised through its minimum funding target of $300000. The company also revealed that Longevitytech.fund has joined the round as a lead investor, bringing the total investment in the company to more than $500000 so far.

“At Longevitytech.fund, we invest in start-ups focused on aging that will materially ‘move the needle,’” says the investment firm’s managing partner, Petr Sramek. “The team at Gerostate Alpha is poised to do just that in the coming years, and we are very excited to partner with them for the long haul.”

Longevity. Technology: For early stage biotech companies, particularly those targeting aging, securing funding is a constant challenge. Gerostate Alpha is “testing the water” by exploring crowdfunding as another financing option, and seems to have had some success with it. We caught up with the company’s co-founders Simon Melov and Mark Lucanic to find out more.

Exercise: Good for your mind, body, and telomeres!

Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. Materials and methods: 30 inactive students were selected as sample and randomly divided into two groups of exercise (15 people) and control (15 people) in this semi-experimental study. The exercise group performed 8 weeks of HIIT exercise in 3 sessions per week with an intensity of 150 to 175% of their maximum power (Pmax). Control group subjects did not do regular sport activities. To measure telomere length and telomerase activity, 10 ml of blood was taken from the brachial vein of the subjects 24 hours before the first and after the last exercise session. The dependent t was used to analyze intra-group and independent t for within-group differences. Results: The findings of this study showed that 8 weeks of HIIT training in non-athlete young men resulted in a significant increase in telomere length (P = 0.001) and telomerase activity (P = 0.001). Conclusion: It seems that HIIT can alter telomerase activity and telomere length. Therefore, these training may have a positive effect on cell biology.

The science and technology of growing young — sergey young, founder, longevity vision fund.

Sergey Young (https://sergeyyoung.com/) is a longevity investor, visionary, and author, with a mission to help one billion people extend their healthy lifespans by making longevity affordable and accessible for everyone. As part of this mission, he is the Founder of the Longevity Vision Fund (LVF — https://lvf.vc/), a $100 Million venture capital fund that invests in technologies with the potential to disrupt life sciences and healthcare to help people live longer and healthier lives.

Continue reading “Sergey Young — Founder, Longevity Vision Fund — Longevity Venture Partner, BOLD Capital Partners” »

Links to biological age calculators:
Levine’s PhenoAge calculator is embedded as an Excel file:

https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Continue reading “Quantifying Biological Age: Blood Test #3 in 2021” »

More TAME! The first part of this has a lot of result data.

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
2021 program & apply to join: https://foresight.org/biotech-health-extension-program/

Continue reading “TAME Q&A: Lessons for Progress on Aging | Nir Barzilai, Albert Einstein School of Medicine” »

4:47 BioAge, 8:10 Church talking about how controlling aging is no longer speculative, 10:44 urging caution as they are not really talking about turning 67 year olds into 20 year olds. Near the end Church mentions A.I. an exponential possibilities of hitting all the pathways at once.

Recently, Avi Roy, alongside Nathan Cheng & Laura Minquini, hosted the second Longevity Panel discussion, which assembled some of the brightest minds working on reversing aging, and enhancing health and life span.

Continue reading “Longevity Panel II — The Scientists Working of Reversing Aging | Part 1” »

I know that this is controversial in the longevity community, but there was overwhelming agreement among the dentists I talked with that mouthwash is excellent for preventing gingivitis (one study found that it was more effective than flossing) and reducing plaque.

Are you working to extend your healthspan and lifespan? Address the most common aging teeth problems with these dentist-approved tricks.