Lifeboat Foundation

Additionally, epigenetic changes were suggested to be a possible link [30, 31] between adverse childhood experiences and mortality as well as higher morbidity burden in late life [32]. It was proposed that this link could be mediated by health-adverse coping mechanisms (activated as a result of high levels of anxiety and depression) that are associated with adverse childhood experiences [33]. Some of these coping strategies, such as smoking, alcohol abuse and and a high BMI resulting from unhealthy eating habits, were shown to be associated with DNAmAA in some studies [34,35,36]. However, these results were not unequivocally replicated [37,38,39] (reviewed in ref. [40]).

Previous studies that examined the relationship between DNAmAA and stress operationalized stress as low socioeconomic status (SES) [41, 42], (childhood) trauma [26, 43,44,45], racial discrimination [46], or exposure to violence [47]. Many previous studies on the topic focused on changes in DNAm age during childhood as this period is known to be particularly prone to stress-related epigenetic changes [29].

In contrast, in this work we focus on older age which was shown to be the second most vulnerable phase in a person’s life in terms of epigenetics [29]. As epigenetic modifications remain even after the psychological stimulus has ceased there is the possibility of cumulating effects on the epigenome exerted by repeated psychological stressors [29]. Specifically, we analyzed the association between the amount of experienced stress (measured by Cohen’s Perceived Stress Scale [PSS] [48]) and several DNAm age estimators (i.e. the 7-CpG clock [49], Horvath’s clock [50], Hannum’s clock [51], PhenoAge [34], GrimAge [52]) in 1,100 older adults. While the PSS represents a well-established marker of perceived stress [48], to our knowledge it has not been investigated in the context of epigenetic aging before. While we were able to replicate well-established associations with perceived stress, none of the five epigenetic clocks analyzed in the current study were associated with the perception of stress.

So one treated rat made it to 45 months which is 113 for people. A 2nd trial is underway to try and increase these results. Also, the human topical test for E5 is just for skin rejuvenation, not fro full rejuvenation or lifespan increase for people.

In this video we report on the August 2022 update from Dr. Katcher’s experiment with E5 along with some other details about the book launch in other languages, the new experiment and topical E5 for humans!

Continue reading “Dr Katcher’s E5 Experiment September 2022 Update | Review” »

There are many ways one can hurt themselves.

When we feel lonely or sad, we may tend to retreat to our shelves or surround ourselves with the people we trust just to put a temporary band-aid on the sorrow we experience. However, finding no cure to being actually alone and unhappy for a long time can have devastating effects not only on our mental health but also on our physical health, hence our appearance.

Scientists just confirmed that prolonged loneliness and unhappiness could accelerate the aging process of an individual, according to a study published in the journal Aging-US.

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GUEST BIO:
Ray Kurzweil is an author, inventor, and futurist.

Continue reading “Will Ray Kurzweil live forever? | Lex Fridman Podcast Clips” »

The NUHS Centre for Healthy Longevity will look for biomarkers of ageing and test ways to slow ageing.

All eyes are on the Emerald Isle this week as the Longevity Summit Dublin brings together a host of speakers covering the spectrum of this booming sector. Delegates have been hearing from some of the leading entrepreneurs, companies, investors, and researchers in the field as they address many of the hot-button topics affecting longevity. One of those speakers is the so-called “father of genomics” – Harvard professor of genetics, George Church – who closes the conference later today with a keynote on Gene, cell and organ therapies for de-aging.

Longevity. Technology: In addition to his Harvard professorship, Church heads up synthetic biology at the Wyss Institute, where he oversees development of new tools with applications in regenerative medicine. Much of his focus more recently has been on the development of gene therapies targeting age-related disease, a passion that led him to co-found Rejuvenate Bio, with the goal of creating “full age reversal gene therapies.” We caught up with Church ahead of his Dublin presentation for a brief conversation on longevity.

Dr Church’s name is synonymous with genomic science, and he was a key contributor to the Human Genome Project and technologies including next-generation fluorescent and nanopore sequencing, aimed at understanding genetic contributions to human disease. However, he doesn’t feel that those initiatives did a huge amount to move the aging field forward.

Physics is not the first scientific discipline that springs to mind at the mention of DNA, but a group of scientists, including John van Noort from the Leiden Institute of Physics (LION) have discovered a new structure of telomeric DNA.

Longevity. Technology: In every cell of our bodies are chromosomes that carry genes that determine our characteristics. At the ends of these chromosomes are telomeres, which protect the genes from damage. Telomeres are rather like aglets, the plastic tips at the end of a shoelace – they protect the DNA from damage and fraying. However, every time a cell divides, the telomeres become shorter, until eventually the Hayflick Limit is reached, the cell can no longer divide and apoptosis – programmed cell death – occurs.

This means that telomeres are sometimes seen as the key to living longer, and the researchers behind this new discovery hope it will help us to better understand aging and age-related diseases.

Set to be one of the largest, if not the largest, investment opportunity in the decades to come, longevity is a rapidly accelerating field; the Longevity Investors Conference targets the global investor community, bringing together institutional investors and top class experts for networking and exploration of relevant insights into the field, as well as expert education and investment opportunities.

Longevity. Technology: It’s not long to wait, now until the Longevity Investors Conference, which takes place later this month in Gstadt, Switzerland. The speaker list is full of longevity pioneers and visionaries, and we have been lucky enough to be given the opportunity to ask them some of our burning longevity questions.

Longevity. Technology readers can get their exclusive invitation to the leading investors-only longevity conference HERE.

Hot on the heels of its €7.4 million raise to accelerate remote medical diagnostics, Certific has announced it is partnering with healthtech startup PocDoc to tackle the world’s biggest killer – cardiovascular disease.

The novel screening will allow patients to remotely monitor blood pressure, BMI and, crucially, quantitative lipid levels through the same user experience. This solution will be rolled out through a number of pilots, in conjunction with the NHS, across the UK, and eventually across Europe and globally.

Longevity. Technology: Heart and circulatory diseases cause a quarter of all deaths in the UK – that’s more than 160,000 deaths each year, or one every three minutes. There are around 7.6 million people living with a heart or circulatory disease in the UK. This costs the country’s National Health Service (NHS) an estimated £7.4 billion per year, with a wider cost to the economy of around £15.8 billion. Early identification of those at highest risk can ensure appropriate treatment, prevent many cases and reduce the strain on the healthcare system.