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Neuroscientists from St. Petersburg University, led by Professor Allan V. Kalueff, in collaboration with an international team of IT specialists, have become the first in the world to apply the artificial intelligence (AI) algorithms to phenotype zebrafish psychoactive drug responses. They managed to train AI to determine—by fish response—which psychotropic agents were used in the experiment.

The research findings are published in the journal Progress in Neuro-Psychopharmacology and Biological Psychiatry.

The zebrafish (Danio rerio) is a freshwater bony fish that is presently the second-most (after mice) used model organism in biomedical research. The advantages for utilizing zebrafish as a model biological system are numerous, including low maintenance costs and high genetic and physiological similarity to humans. Zebrafish share 70% of genes with us. Furthermore, the simplicity of the zebrafish nervous system enables researchers to achieve more explicit and accurate results, as compared to studies with more complex organisms.

Existing quantum devices can actually do things that we cannot compute with classical computers. The question is only can we harness this computational power that is apparently there,” van Bijnen says. “Maybe doing arbitrary computational problems is a bit much to ask, so we are now looking at whether we can match problems well to available quantum hardware.” Many current experiments involving Rydberg atoms would likely not require any radical changes in instrumentation that is already being used, he adds.

A chip-based infection model developed by researchers in Jena, Germany, enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis. The team developed algorithms to track the spread of fungal hyphae as well as the response of immune cells. The development is based on a “lung-on-chip” model also developed in Jena and can help reduce the number of animal experiments. The results were presented in the journal Biomaterials.

Aspergillosis is a mold infection caused by Aspergillus fumigatus, which often affects the lungs. The disease can be fatal, especially in immunocompromised individuals. In these cases, invasive aspergillosis usually occurs with fungal hyphae invading blood vessels. So far, there are only a few active substances that can combat such fungal infections. “That’s why it was so important for us to be able to represent this invasive growth in a model,” says Marie von Lilienfeld-Toal, who co-led the study. The internist is a professor at the Department of Internal Medicine II at Jena University Hospital and conducts research at the Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute (Leibniz-HKI) in Jena, Germany.

The new aspergillosis infection model should help to better observe both the growth of the fungus and the reaction of the immune system and to find possible new approaches for therapies. In addition, new active substances can be tested. The expertise for this is available in Jena: Organ chips have long been developed at the university hospital. The startup Dynamic42, which manufactures the lung chips used in the study, was founded there. First author Mai Hoang also joined the company after completing her doctorate.

When Dr. Shiran Barber-Zucker joined the lab of Prof. Sarel Fleishman as a postdoctoral fellow, she chose to pursue an environmental dream: breaking down plastic waste into useful chemicals. Nature has clever ways of decomposing tough materials: Dead trees, for example, are recycled by white-rot fungi, whose enzymes degrade wood into nutrients that return to the soil. So why not coax the same enzymes into degrading man-made waste?

Barber-Zucker’s problem was that these enzymes, called versatile peroxidases, are notoriously unstable. “These natural enzymes are real prima donnas; they are extremely difficult to work with,” says Fleishman, of the Biomolecular Sciences Department at the Weizmann Institute of Science. Over the past few years, his lab has developed computational methods that are being used by thousands of research teams around the world to design enzymes and other proteins with enhanced stability and additional desired properties. For such methods to be applied, however, a protein’s precise molecular structure must be known. This typically means that the protein must be sufficiently stable to form crystals, which can be bombarded with X-rays to reveal their structure in 3D. This structure is then tweaked using the lab’s algorithms to design an improved protein that doesn’t exist in nature.

Despite millions of dollars in losses by the likes of Zillow, iBuying’s failure doesn’t signal the end of tech-led disruption, just a fumbled beginning.

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Director: Alex Vikoulov.
Narrator: Forrest Hansen.
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The work, led by Johns Hopkins University researchers, is detailed today in Nature Cardiovascular Research.

We are already living in the future. Our everyday lives are influenced by robots in many ways, whether we’re at home or at work. As artificial intelligence, open source algorithms, and cloud technology have been developed in recent years, they have contributed to creating favorable conditions for robot revolution, which is closer than you might expect.

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The growth potential of intelligent machines is attaining milestones almost every other day. Each day, new publications and media houses are reporting the new achievements of AI. But there were still questions about the creative potential of AI. Experts believe that artificial intelligence machines will never be able to achieve the creative consciousness that human intelligence possesses. Well, AI has again proved them wrong! The technology is now capable of creating its own art, out of its own imagination, and also poetry, that only the most deeply conscious human brains can do.

There have been several instances where programming and poetry have converged into generating some of the most outstanding pieces in the history of tech. Programming itself has its own set of minimalist aesthetics that does not take up much space and does not take too long to execute. Also, there have been many programmers who had links to poetry and art, which makes it easier for them to curate a mindblowing tech that can yield the same standard of results. Nowadays, companies like OpenAI create futuristic technology that is not only advanced but also boldly creative. In fact, its poetry-writing AI has made huge strides over the internet!

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