Lifeboat Foundation

On the internet, nothing is safe — not even your DNA, apparently.

That’s the dystopian lesson from the commercial genetic testing company 23andMe, which disclosed on Friday in a regulatory filing that hackers managed to access information on about 14,000 users or 0.1 percent of its customer user base.

But the problem goes beyond this relatively small number of people. Because the website allows users to share DNA information with other users in order to find relatives, the true number impacted is orders of magnitude larger — with about 6.9 million customers having their personal information compromised, according to TechCrunch. Big yikes on that figure, because it affects something like half of the 14 million users at 23andMe.

Scientists have created tiny, self-assembling robots made from human cells that could one day repair damaged skin and tissue.

These tiny biological machines, called Anthrobots, are made from human tracheal cells without any genetic modification. Lab dish experiments revealed they can encourage neurons, or nerve cells, to grow in damaged tissue.

https://www.youtube.com/watch?v=1-fNggTpGWQ

So if I heard this right, after 8 minutes or so, the effects are temporary and he indicates people would have to take this every couple of years.

Here Akshay talks about his interest in aging, how he met with Dr Katcher and formed Yuvan Research and their experiments with E5 and the results that they saw.
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Continue reading “Reducing Biological Age By 67% : The Origins Of E5” »

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then hold those antibodies in abeyance in case they encounter that same pathogen again, the way we do. Instead, they incorporate some of the pathogen’s DNA into their own genome and link it to an enzyme that can use it to recognize that pathogenic DNA sequence and cut it to pieces if the pathogen ever turns up again.

The enzyme that does the cutting is called Cas, for CRISPR associated. Although the CRISPR-Cas system evolved as a bacterial defense mechanism, it has been harnessed and adapted by researchers as a powerful tool for genetic manipulation in laboratory studies. It also has demonstrated agricultural uses, and the first CRISPR-based therapy was just approved in the UK to treat sickle-cell disease and transfusion-dependent beta-thalassemia.

Now, researchers have developed a new way to search genomes for CRISPR-Cas-like systems. And they’ve found that we may have a lot of additional tools to work with.

The world’s largest collection of full human genomes has just gone live.

The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.

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Continue reading “Blood Test #7 in 2023: 15 — 21y Younger Biological Age” »

After five years, more than 350,000 hours of genome sequencing, and over £200 million of investment, UK Biobank is releasing the world’s largest-by-far single set of human sequencing data—completing the most ambitious project of its kind ever undertaken. The new data, whole genome sequences of its half a million participants, will certainly drive the discovery of new diagnostics, treatments, and cures. Uniquely, the data are available to approved researchers worldwide, via a protected database containing only de-identified data.

This advance lies not only in the abundance of genomic data, but its use in combination with the existing data UK Biobank has collected over the past 15 years on lifestyle, whole body imaging scans, health information, and proteins found in the blood. The Pharma Proteomics Project was published last month in Nature, in the paper, “Plasma proteomic associations with genetics and health in the UK Biobank.”

Looking forward, these data could be used to further advance efforts such as more targeted drug discovery and development, discovering thousands of disease-causing noncoding genetic variants, accelerating precision medicine, and understanding the biological underpinnings of disease.

Vertex Pharmaceuticals plans to sell a gene-editing treatment for sickle-cell disease. A patent on CRISPR could stand in the way.

Protein-like aggregates known as amyloids can bind to molecules of genetic material. It is possible that these two types of molecules stabilized each other during the development of life—and that this might even have paved the way for the genetic code.

How organisms develop from inanimate matter is one of the biggest questions in science. Although many possible explanations have been proposed, there are no definitive answers. That’s no surprise: these processes took place 3 billion to 4 billion years ago, when the conditions on Earth were completely different from today.

“Over this vast period of time, evolution has thoroughly obliterated the traces that lead back to the origins of life,” says Roland Riek, professor of physical chemistry and associate director of ETH Zurich’s new interdisciplinary Center for Origin and Prevalence of Life. Science has no choice but to formulate hypotheses—and to substantiate them as thoroughly as possible with experimental data.