Lifeboat Foundation

Young blood plasma is known to confer beneficial effects on various organs in mice. However, it was not known whether young plasma rejuvenates cells and tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly-accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation values derived from n=593 tissue samples. As indicated by their respective names, the rat pan-tissue clock can be applied to DNA methylation profiles from all rat tissues, while the rat brain-, liver-, and blood clocks apply to the corresponding tissue types. We also developed two epigenetic clocks that apply to both human and rat tissues by adding n=850 human tissue samples to the training data. We employed these six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. The treatment more than halved the epigenetic ages of blood, heart, and liver tissue. A less pronounced, but statistically significant, rejuvenation effect could be observed in the hypothalamus. The treatment was accompanied by progressive improvement in the function of these organs as ascertained through numerous biochemical/physiological biomarkers and behavioral responses to assess cognitive functions. Cellular senescence, which is not associated with epigenetic aging, was also considerably reduced in vital organs. Overall, this study demonstrates that a plasma-derived treatment markedly reverses aging according to epigenetic clocks and benchmark biomarkers of aging.

Several authors are founders, owners, employees (Harold Katcher and Akshay Sanghavi) or consultants of Nugenics Research (Steve Horvath and Agnivesh Shrivastava) which plans to commercialize the “Elixir” treatment. Other authors (Kavita Singh, Shraddha Khairnar) received financial support from Nugenics Research. The other authors do not have conflict of interest.

“The main purpose of the stock market is to make fools of as many men as possible.”–Bernard Baruch.

The choices we make today, and it’s consequences will shape up this decade. Can we break the current pattern, engage with this new financial system and adapt to new realities? #blockchain

As human beings, we are defined by patterns. Our collective pattern defines society. We are empowered with choices – furthering the patterns, or breaking them or creating new ones. In the physical world, these choices could be social, economic, technological, or ecological. Based on the choices we make – good, bad, or ugly, we enjoy or suffer consequences. COVID-19 escalated the macroeconomic situation leading to liquidity, demand, and supply shocks. Can we break the current pattern and embrace digitization, decentralization and sound money? In turn, making choices that will create affirmative consequences for humanity.

Patterns, Choices & Consequences

Continue reading “Patterns, Choices & Consequences” »

Renewable sources including solar, wind and hydropower generated more electricity than coal-based plants every single day in April, a new report says.

Analysis shared by the Institute for Energy Economics and Financial Analysis (IEFA), based on data from the U.S. Energy Information Administration (EIA), said the finding marks a major “milestone” in an energy transition that is now underway.

Continue reading “America’s renewable energy sources have produced more electricity than coal every day for 40 days straight” »

Imagine being able to know when a stock is heading up or going down in the next week and then with the remaining cash you have, you would put all of your money to invest or short that stock. After playing the stock market with the knowledge of whether or not the stock will increase or decrease in value, you might end up a millionaire!

Unfortunately, this is impossible because no one can know the future. However, we can make estimated guesses and informed forecasts based on the information we have in the present and the past regarding any stock. An estimated guess from past movements and patterns in stock price is called Technical Analysis. We can use Technical Analysis (TA)to predict a stock’s price direction, however, this is not 100% accurate. In fact, some traders criticize TA and have said that it is just as effective in predicting the future as Astrology. But there are other traders out there who swear by it and have established long successful trading careers.

In our case, the Neural Network we will be using will utilize TA to help it make informed predictions. The specific Neural Network we will implement is called a Recurrent Neural Network — LSTM. Previously we utilized an RNN to predict Bitcoin prices (see article below):

Maria became the very first COVID-19 patient to use Stem Cell Neurotherapy for COVID-19. In about 5 days, she will began to feel the healing effects of generating new lung cells which will eliminate her breathing problems.

We repurposed some tools from the Stem Cell Therapy for Cancer/Brain Tumor. Those tools are T-Cells, B-Cells, and Natural Killer Cells. Instead of programming those cancer killing cells to attack cancer cells, we have programmed them to seek out, identify, attack, and destroy all the Coronavirus cells in the entire body.

Stem Cell Neurotherapy sends therapeutic messages, e.g., “your stem cells are transforming into new cells for the lungs, liver, and kidneys” to the DNA inside the nucleus of stem cells. Inside the nucleus, the DNA receives the message and transmits it to the RNA, which translates the message into genetic code.

Continue reading “Help NYC artist Maria Alekseev” »

Elon Musk tweeted a complaint about Tesla’s share price that wiped $14bn off the company’s stock market value on Friday morning.

The seven-word tweet was the latest controversial outburst from the outspoken chief executive, whose outpourings on Twitter have landed him in hot water before. An incorrect claim in the middle of 2018 that he was close to a buyout of Tesla led to a complaint from the US Department of Justice and a settlement that involved Mr Musk agreeing not to issue market-moving tweets in future without first clearing them with his company’s legal department.

Tesla did not immediately confirm whether Mr Musk’s tweet had been given legal clearance, and did not respond to a question about whether the company currently has a general counsel. Tesla lost three general counsels last year, one of them quitting after only two months.

Five of the world’s biggest central banks recently announced that they’ve banded together to seriously explore central bank digital currencies.

Over at the always interesting Small Wars Journal, Tony Corn has a stimulating piece on the implications of the European crisis for world politics. He sees a clueless German policy establishment recklessly moving toward an unsustainable quest for power reminiscent in too many ways of problems Germany has had in its past.

Germany, warns Corn, is planning to use its financial domination of Europe to remake the EU into an extension of German power — more or less the way that Prussia used the Zollverein to bring northern Germany under its control and then dominated the Bismarckian Reich through a rigged constitutional system. Once that is in place, he writes, the Germans will continue their policy of deepening relations with Russia at the expense of NATO and transatlantic ties, and end Europe’s embargo on arms sales to China.

As an analyst, Corn sometimes goes to what we more placid types at VM consider overexcited conclusions about Eurasian power realignments. Safely ensconced among the storied oaks and elms, gazebos, pergolas, ha-has, follies and deer parks surrounding the stately Mead manor in glamorous Queens, we tend to take a wait-and-see attitude toward organizations like the Shanghai Cooperation Organization which Russia and China have sometimes posited as a kind of embryonic counter-NATO. Corn, in our perhaps excessively complacent view, can be too quick to take vague Eurasian fantasies and aspirations about diplomatic revolutions as accomplished facts; it is easier to dream about firm Russian and Chinese anti-US cooperation than for those two countries to make it work. But that said, there is no doubt that Corn’s industry, historical grounding and sensitive, even over-sensitive nerve endings give him the ability to produce original and striking ideas.