Lifeboat Foundation

EVP, patient advocacy & engagement, national patient advocate foundation.

Gwen Darien is Executive Vice President for Patient Advocacy and Engagement, at the National Patient Advocate Foundation (https://www.npaf.org/), an organization with a mission of bringing patient voices to health system delivery reform, developing and driving initiatives promoting equitable access to affordable quality health care, and prioritizing the patient voice in health system delivery reform to achieve person-centered care. She is also Executive Vice President at their sister organization, Patient Advocate Foundation (https://www.patientadvocate.org/), a national non-profit organization which provides case management services and financial aid to Americans with chronic, life threatening and debilitating illnesses.

Continue reading “Gwen Darien — EVP, Patient Advocacy and Engagement, National Patient Advocate Foundation” »

The Chinese economy has been hit by a perfect storm. In the third quarter of the ongoing financial year, official Chinese data revealed that GDP growth stood at 4.9 percent, down from 7.9 percent in the previous quarter. This decline in GDP growth is directly eating into profits of big Chinese companies.

Rising prices and low consumer spending create a perfect storm in the Chinese economy:

There are two broad factors that are affecting business earnings in China-raw material inflation and low consumer spending.

Talk of war, stagflation and rationing is eroding the country’s confidence and affecting the dynamics of its financial industry.

Rare diseases aren’t so rare. Collectively, up to 30 million Americans, many of them children, are born with one of the approximately 7,000 known rare diseases. Most of these millions of people also share a common genetic feature: their diseases are caused by an alteration in a single gene.

Many of these alterations could theoretically be targeted with therapies designed to correct or replace the faulty gene. But there have been significant obstacles in realizing this dream. The science of gene therapy has been making real progress, but pursuing promising approaches all the way to clinical trials and gaining approval from the U.S. Food and Drug Administration (FDA) is still very difficult. Another challenge is economic: for the rarest of these conditions (which is most of them), the market is so small that most companies have no financial incentive to pursue them.

To overcome these obstacles and provide hope for those with rare diseases, we need a new way of doing things. One way to do things differently—and more efficiently—is the recently launched Bespoke Gene Therapy Consortium (BGTC). It is a bold partnership of NIH, the FDA, 10 pharmaceutical companies, and several non-profit organizations [1]. Its aim: optimize the gene therapy development process and help fill the significant unmet medical needs of people with rare diseases.

The technology aims to deliver cost and power consumption improvements for deep learning use cases of inference, the companies said. This development follows NeuReality’s emergence from stealth earlier in February with an $8 million seed round to accelerate AI workloads at scale.

AI inference is a growing area of focus for enterprises, because it’s the part of AI where neural networks actually are applied in real application and yield results. IBM and NeuReality claim their partnership will allow the deployment of computer vision, recommendation systems, natural language processing, and other AI use cases in critical sectors like finance, insurance, healthcare, manufacturing, and smart cities. They also claim the agreement will accelerate deployments in today’s ever-growing AI use cases, which are already deployed in public and private cloud datacenters.

NeuReality has competition in Cast AI, a technology company offering a platform that “allows developers to deploy, manage, and cost-optimize applications in multiple clouds simultaneously.” Some other competitors include Comet.ml, Upright Project, OctoML, Deci, and DeepCube. However, this partnership with IBM will see NeuReality become the first start-up semiconductor product member of the IBM Research AI Hardware Center and a licensee of the Center’s low-precision high performance Digital AI Cores.

This company’s entry in the US; market; along with other aluminum giants is said to have caused the shutdown of a large number of Aluminum manufacturers based in the US. It seemed that local US companies were unable to compete with state backed companies which were taking advantage of the free trade agreement.

However, the trade tariffs along with recent events have in turn caused this firm to become insolvent. It’s founder is now being detained by the US under fraud charges.

Continue reading “China: Corporate debt crisis spreads/Zhongwang: suspended in stock market & fraud conviction in U.S.” »

There’s no question about it: climate technology is in again.

Over the past several quarters, entrepreneurial activity and investment interest in climate tech have skyrocketed. New funds devoted specifically to climate have launched at an astonishing rate in 2021: from blue-chip venture capital firms like Union Square Ventures, from large private equity players like TPG and General Atlantic, from a whole new breed of climate-specific VCs like Lowercarbon Capital. Scarcely a day goes by now without a climate tech startup announcing a major new funding round. A whopping $49 billion of venture capital funding will pour into climate tech in 2021.

BlackRock CEO Larry Fink aptly captured the current ebullience when he declared last week that “the next 1,000 unicorns” will be in climate tech.

China’s economy — the 2nd-largest in the world — is teetering on the brink of disaster.

Since this spring, Beijing has canceled initial public offerings, fined tech companies billions for antitrust violations, forcibly shut down China’s entire for-profit education industry, and sent CEOs running for the exits to avoid the government’s ire. Even more dire, the Chinese megadeveloper Evergrande recently started missing payments on its more than $300 billion in debt, shaking global markets. The convulsions have woken the world up to a startling new possibility — that Beijing may be willing to allow some of its private corporate behemoths to collapse in a bid to reshape the economic model that made China a superpower.

Continue reading “If China’s economy keeps stumbling, it won’t just take down Beijing — the whole world will collapse with it” »

Cell culture is an essential in vitro experimental tool. An attempt to recapitulate the body in a dish, in two and three dimensions, it has provided the basis for decades of research and probably thousands of PhDs. When it goes wrong, however, whether through accident, infection, misidentification, cross-contamination or uncontrolled differentiation (for stem cells), it can be very stressful, especially in the case of longer-term experiments or when using hard-to-replace cell lines. Another important consideration is reproducibility, which is an acknowledged life sciences industry issue. A 2015 PLOS Biol ogy study, for example, reported in an analysis of previous studies that the prevalence of irreproducible research was over 50% – equivalent to USD $28 billion per year on irreproducible preclinical research.¹ Inconsistencies in cell culture approaches are a potential issue in this regard, as if cells are not maintained or used in a consistent way, or are contaminated with an infection (like mycoplasma), this can negatively impact results and make it more difficult to reproduce and/or accurately interpret data.

“Quality control (QC) is a key part of assuring the quality of outputs from any cell culture process, and is an essential part of assuring reproducibility of scientific quality in research as well as assurance of the quality and safety of cell culture-derived products,” comments Glyn N Stacey, International Stem Cell Banking Initiative, Cambridge, UK, and the Institute for Stem Cells and Regeneration and National Stem Cell Resource Centre, Chinese Academy of Sciences, Beijing, China. “These topics are currently very much in the minds of journal editors, research funders and regulators and are thus of crucial significance to researchers.”

This article will look at these different aspects of cell culture quality control and the types of protocols that can be implemented to help ensure reliable and reproducible results.