Lifeboat Foundation

Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer.

The findings were recently the cover story in the journal Genome Research.

The team of researchers from BGU’s National Institute for Biotechnology in the Negev (NIBN) set out to look for mutations in the genome of the mitochondria, a part of every cell responsible for energy production that is passed exclusively from mothers to their children. The mitochondria are essential to every cell’s survival and our ability to perform the functions of living.

The cells inside a tumour change and evolve just like animals in the wild. Understanding how this works could help us stop cancer in its tracks.

Scientists believe that time is continuous, not discrete—roughly speaking, they believe that it does not progress in “chunks,” but rather “flows,” smoothly and continuously. So they often model the dynamics of physical systems as continuous-time “Markov processes,” named after mathematician Andrey Markov. Indeed, scientists have used these processes to investigate a range of real-world processes from folding proteins, to evolving ecosystems, to shifting financial markets, with astonishing success.

However, invariably a scientist can only observe the state of a system at discrete times, separated by some gap, rather than continually. For example, a stock market analyst might repeatedly observe how the state of the market at the beginning of one day is related to the state of the market at the beginning of the next day, building up a conditional probability distribution of what the state of the second day is given the state at the first day.

In a pair of papers, one appearing in this week’s Nature Communications and one appearing recently in the New Journal of Physics, physicists at the Santa Fe Institute and MIT have shown that in order for such two–time dynamics over a set of “visible states” to arise from a continuous-time Markov process, that Markov process must actually unfold over a larger space, one that includes hidden states in addition to the visible ones. They further prove that the evolution between such a pair of times must proceed in a finite number of “hidden timesteps”, subdividing the interval between those two times. (Strictly speaking, this proof holds whenever that evolution from the earlier time to the later time is noise-free—see paper for technical details.)

Continue reading “The discrete-time physics hiding inside our continuous-time world” »

But not everyone is on board.

“The use of transgenic monkeys to study human genes linked to brain evolution is a very risky road to take,” University of Colorado geneticist James Sikela told the MIT Technology Review. “It is a classic slippery slope issue and one that we can expect to recur as this type of research is pursued.”

Pinpointing the gene’s role in intelligence could help scientists understand how humans evolved to be so smart, MIT Tech reports.

Continue reading “Chinese Scientists Gene-Hacked Super Smart Human-Monkey Hybrids” »

“Why are we impatient? It’s a heritage from our evolution,” says Marc Wittmann, a psychologist at the Institute for Frontier Areas of Psychology and Mental Health in Freiburg, Germany. Impatience made sure we didn’t die from spending too long on a single unrewarding activity. It gave us the impulse to act.

Not long ago I diagnosed myself with the recently identified condition of sidewalk rage. It’s most pronounced when it comes to a certain friend who is a slow walker. Last month, as we sashayed our way to dinner, I found myself biting my tongue, thinking, I have to stop going places with her if I ever want to … get there!

You too can measure yourself on the “Pedestrian Aggressiveness Syndrome Scale,” a tool developed by University of Hawaii psychologist Leon James. While walking in a crowd, do you find yourself “acting in a hostile manner (staring, presenting a mean face, moving closer or faster than expected)” and “enjoying thoughts of violence?”

Continue reading “Why Your Brain Hates Slowpokes” »

Galor says the study results, published on Monday, April 1, in Nature Ecology & Evolution, lend credence to what he and a colleague had surmised in a highly influential 2002 paper — that during the pre-industrial era, the natural selection of those who were genetically predisposed toward having fewer children was instrumental in spurring industrialization and sustained economic growth.

In a study of 200 years of pre-industrial Quebecois genealogical history, researchers at Brown found that fertility-related changes in natural selection during the pre-industrial era paved the way for economic and technological progress.

Conventional DNA is comprised of the familiar A, C, G, and T base pairs, but a newly created genetic system is packed with eight, thus doubling the number of letters normally found in self-replicating molecules. Intriguingly, the new system, dubbed “hachimoji,” could resemble the building blocks of extraterrestrial life.

New research published yesterday in Science describes the hachimoji, which means “eight letters” in Japanese. In addition to the conventional four base pairs, this genetic system has an extra four building blocks, dramatically increasingly the information density compared to regular DNA. The scientists behind the work, led by Steven Benner from the Foundation for Applied Molecular Evolution in Alachua, Florida, said the new system may be robust enough to support life, that is, to support the processes required for Darwinian self-replication.

The discovery of a fossilized, 42-million-year-old, four-legged whale is shedding new light on the evolution and geographical spread of these aquatic mammals.

The ancestors of modern whales and dolphins evolved from a small, four-limbed hoofed animal that lived in south Asia around 50 million years ago, during the Eocene. Fossil evidence suggests these aquatic mammalian pioneers reached North America by 41.2 million years ago, swimming from West Africa across the Atlantic. The surprise discovery of a previously unknown, 42.6-million-year-old quadrupedal whale along the coast of Peru has resulted in an important addendum to this story: Ancient whales made South America, and not North America, their first home in the New World. Details of this discovery were published today in Current Biology.

Today our middle-aged Universe looks eerily smooth. Too smooth, in fact.

While a rapid growth spurt in space-time would explain what we see, science needs more than nice ideas. It needs evidence that whittles away contending arguments. We might finally know where to look for some.

A team of physicists from the Centre for Astrophysics | Harvard & Smithsonian (CfA) and Harvard University went back to the drawing board on the early Universe’s evolution to give us a way to help those inflation models stand out from the crowd.

Continue reading “What Existed Before The Big Bang? Astronomers Have Found a Test to Narrow It Down” »