Lifeboat Foundation

Optothermal nanotweezers are an innovative optical design method that has revolutionized classical optical techniques to capture a broad range of nanoparticles. While the optothermal temperature field can be employed for in situ regulation of nanoparticles, challenges remain in identifying their potential for regulating bionanoparticles.

To observe the synergistic effects of optothermal manipulation and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based biodetection, the researchers developed a combination of CRISPR-powered optothermal nanotweezers abbreviated as CRONT.

In a new report in Light: Science & Applications, Jiajie Chen and a research team in optoelectronics engineering, biomedical engineering, and physics, accomplished this by harnessing diffusiophoresis and thermo-osmotic flows for optothermal excitation by successfully enriching DNA functionalized gold nanoparticles, CRISPR-associated proteins, and DNA strands.

The technique represents an important step in engineering skin grafts, drug testing. A team led by scientists at Rensselaer Polytechnic Institute has 3D-printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function.

The finding, published in the journal Science Advances, has potential applications in regenerative medicine and drug testing, though engineering skin grafts that grow hair are still several years away.

“Our work is a proof-of-concept that hair follicle structures can be created in a highly precise, reproducible way using 3D-bioprinting. This kind of automated process is needed to make future biomanufacturing of skin possible,” said Pankaj Karande, Ph.D., an associate professor of chemical and biological engineering and a member of Rensselaer’s Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, who led the study.

Carlos Bravo-Prieto^1,2,3, Ryan LaRose⁴, M. Cerezo^1,5, Yigit Subasi⁶, Lukasz Cincio¹, and Patrick J. Coles¹

¹Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87,545, USA. ² Barcelona Supercomputing Center, Barcelona, Spain. ³ Institut de Ciències del Cosmos, Universitat de Barcelona, Barcelona, Spain. ⁴ Department of Computational Mathematics, Science, and Engineering & Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48,823, USA. ⁵ Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA ⁶ Computer, Computational and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87,545, USA

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Tesla has made its original Roadster design and engineering “fully open source” and released R&D documents accessible to everyone.

The original Tesla Roadster hasn’t been in production for more than a decade now, and we are still waiting for the new generation that was unveiled all the way back in 2017 and has been delayed several times since.

The vehicle has become quite rare.

In 1960, DARPA funded three university-based Inderdisciplinary Laboratories (IDLs) that opened the way toward an enormous field of research and development known today as materials science and engineering. In this video, DARPA program managers, DARPA-funded researchers, and a Naval Research Laboratory scientist tell this field-building story as it unfolded over the past six decades, all the while delivering breakthroughs in the way materials are designed, processed, and deployed to push technologies forward. Intelligent processing of materials (IPM), accelerated insertion of materials (AIM), and integrated computational materials engineering (ICME) are among the specific programs detailed in the video. DARPA is currently developing technologies that enable the crafting of new materials with unprecedented properties by designing and controlling matter from atoms on up to human-scale systems.

Tesla has open-sourced all of the design and engineering of the original Roadster, CEO Elon Musk announced today, and plenty of people are wondering if the timing of the release has anything to do with the next-gen Roadster that is now several years behind schedule.

Tesla has opened everything from Owner’s Manuals to Circuits and Connectors for the original Roadster, which was the automaker’s first project fifteen years ago in 2008.

The vehicle was essentially a fundraising campaign for Tesla as it fought to keep its doors open and transform the passenger vehicle industry. It almost bankrupted the company, but now, everything that was developed for Tesla’s initial EV project is available for anyone to take a look at.

In laser-based manufacturing, accommodating non-flat, or changing surfaces has traditionally been labor-intensive, involving complex focus mapping procedures and or ex-situ characterization. This often results in repositioning errors and extended processing times.

To address these issues, ultra-high-speed auto-focusing in laser processing has been developed. Whereas most auto-focusing techniques still require the mechanical motion of a motorized stage. This mechanical movement in the beam propagation axis can be significantly slower than the lateral speed, slowing down the process of surface detection and re-alignment. Furthermore, it requires feedback, control, and sensing methods in order to determine the optical focal position.

In a new paper published in Light: Science & Applications, a team of researchers, led by Professor Craig B. Arnold from the Department of Mechanical and Aerospace Engineering at Princeton University, U.S., developed a fast method to simultaneously track the specific location of a surface and adjust the focus of an optical system. They employed axial varifocal optics, specifically a TAG lens, which operates at 0.1−1 MHz, bypassing delays from the mechanical motion in the beam propagation direction.

Macrophages, small but essential cells in the immune system, hold promise for cell-based therapies in numerous health conditions. Unlocking the full potential of macrophage therapies depends on our ability to observe their activities within the body. Now, researchers from Penn State have potentially developed a method to monitor these cells in action.

In a study published in the journal Small, the Penn State researchers report a novel ultrasound imaging technique to view macrophages continuously in mammal tissue, with potential for human application in the future.

“A macrophage is a type of immune cell that is important in nearly every function of the immune system, from detecting and clearing pathogens to wound healing,” said corresponding author Scott Medina, the William and Wendy Korb Early Career Associate Professor of Biomedical Engineering. “It is a component of the immune system that really bridges the two types of immunity: innate immunity, which responds to things very quickly but in a not very precise way, and adaptive immunity, which is much slower to come online but responds in a much more precise way.”

Security researchers bypassed Windows Hello fingerprint authentication on Dell Inspiron, Lenovo ThinkPad, and Microsoft Surface Pro X laptops in attacks exploiting security flaws found in the embedded fingerprint sensors.

Blackwing Intelligence security researchers discovered vulnerabilities during research sponsored by Microsoft’s Offensive Research and Security Engineering (MORSE) to assess the security of the top three embedded fingerprint sensors used for Windows Hello fingerprint authentication.

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