Lifeboat Foundation

Year 2018 face_with_colon_three

Pediatric Research volume 83, pages 223–231 (2018) Cite this article.

I have a new essay out via the wonderful site Merion West. The article is based on some of my experimental writings at Oxford. I hope you’ll read and consider it. I’m highly worried life extension science isn’t moving forward fast enough!

“Sadly, biological humans are likely to be mortal for centuries more, unless a dramatic increase of both resources and life extension scientists are marshaled.”

Certain well-known gerontologists and longevity experts around the world believe that sometime in this century—probably in the next 15–50 years—medicine will likely overcome and cure most forms of disease, and even death itself. Billionaires such as Meta’s Mark Zuckerberg, Amazon’s Jeff Bezos, Alphabet’s Larry Page, and Oracle’s Larry Ellison have jumped on board, pledging billions of dollars to “conquering all disease by this century” and mortality altogether.

Continue reading “When We’re Overly Optimistic about the Pace of Life Extension Research” »

Nanomaterials manufacturing, 3D bioprinting, and astronaut eye health were the main research topics aboard the International Space Station on Friday. The Expedition 71 crew members also continued servicing spacesuits and conducted an emergency drill.

The SpaceX Dragon cargo spacecraft recently delivered to the orbital outpost a biotechnology study to demonstrate the in-space production of nanomaterials that mimic DNA. NASA Flight Engineers Jeanette Epps and Mike Barratt worked on the second portion of that experiment on Thursday mixing then treating the research samples for analysis. Epps began her day mixing solutions in the Life Science Glovebox to create specialized nanomaterials. During the afternoon, Barratt applied sound and light treatments to the samples then stowed them aboard Dragon for analysis back on Earth. Results may lead to advanced therapies for space-caused and Earthbound health conditions.

The duo partnered back together at the end of the day for eye scans using standard medical imaging gear found in an optometrist’s on Earth. Barratt operated the hardware with guidance from doctors on the ground peering into Epp’s eyes and examining her retina and optic nerve for the B Complex eye health investigation.

Vidmantas Šakalys explains how laser technology is advancing bioprinting and opening up new possibilities in regenerative medicine.

In the last decade, the advances made into the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) led to great improvements towards their use as models of diseases. In particular, in the field of neurodegenerative diseases, iPSCs technology allowed to culture in vitro all types of patient-specific neural cells, facilitating not only the investigation of diseases’ etiopathology, but also the testing of new drugs and cell therapies, leading to the innovative concept of personalized medicine. Moreover, iPSCs can be differentiated and organized into 3D organoids, providing a tool which mimics the complexity of the brain’s architecture. Furthermore, recent developments in 3D bioprinting allowed the study of physiological cell-to-cell interactions, given by a combination of several biomaterials, scaffolds, and cells.

Science: In future maybe wounds be cured and closed in seconds by 3D printing regeneration.

Fat tissue holds the key to 3D printing layered living skin and potentially hair follicles, according to researchers who recently harnessed fat cells and supporting structures from clinically procured human tissue to precisely correct injuries in rats. The advancement could have implications for reconstructive facial surgery and even hair growth treatments for humans.

The team’s findings were published March 1 in Bioactive Materials. The U.S. Patent and Trademark Office granted the team a patent in February for the bioprinting technology it developed and used in this study.

Continue reading “3D-printed skin closes wounds and contains hair follicle precursors” »

Scientists from medical tech company Fluicell have partnered with clinical R&D firm Cellectricon and the Swedish Karolinska Institutet university to 3D bioprint neural cells into complex patterns.

Using the microfluidic printheads featured on Fluicell’s Biopixlar platform, the researchers were able to accurately arrange rat brain cells within 3D structures, without damaging their viability. The resulting cerebral tissues could be used to model the progress of neurological diseases, or to test the efficacy of related drugs.

“We’ve been using Biopixlar to develop protocols for the printing of different neuronal cells types, and we are very pleased with its performance,” said Mattias Karlsson, CEO of Cellectricon. “This exciting technology has the potential to open completely new avenues for in-vitro modeling of a wide range of central and PNS-related diseases.”

😀 They say we could even regenerate human limbs this way aswell as repair human blood vessels.

Cell tubes, made entirely from a patient’s own cells, are just as elastic as blood vessels but much stronger. Skin cells cultured into lumps are skewered on needles on a base, similar to a Kenzan, a tool used in Japanese flower arrangements, and formed into a tube. The technique, called the Kenzan Method, was made possible by a 3D bioprinter. A clinical trial is underway in Japan to transplant these tubes into humans in place of blood vessels. Studies are being done to apply them to nerves and organs.

The technique represents an important step in engineering skin grafts, drug testing. A team led by scientists at Rensselaer Polytechnic Institute has 3D-printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function.

The finding, published in the journal Science Advances, has potential applications in regenerative medicine and drug testing, though engineering skin grafts that grow hair are still several years away.

“Our work is a proof-of-concept that hair follicle structures can be created in a highly precise, reproducible way using 3D-bioprinting. This kind of automated process is needed to make future biomanufacturing of skin possible,” said Pankaj Karande, Ph.D., an associate professor of chemical and biological engineering and a member of Rensselaer’s Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, who led the study.