Lifeboat Foundation

Bringing together concepts from electrical engineering and bioengineering tools, Technion and MIT scientists collaborated to produce cells engineered to compute sophisticated functions— biocomputers of sorts.

Graduate students and researchers from Technion—Israel Institute of Technology Professor Ramez Daniel’s Laboratory for Synthetic Biology & Bioelectronics worked together with Professor Ron Weiss from the Massachusetts Institute of Technology to create genetic “devices” designed to perform computations like artificial neural circuits. Their results were recently published in Nature Communications.

The genetic material was inserted into the bacterial cell in the form of a plasmid: a relatively short DNA molecule that remains separate from the bacteria’s “natural” genome. Plasmids also exist in nature, and serve various functions. The research group designed the plasmid’s genetic sequence to function as a simple computer, or more specifically, a simple artificial neural network. This was done by means of several genes on the plasmid regulating each other’s activation and deactivation according to outside stimuli.

Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.

However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there’s no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster—within seconds.

“We now have a methodology for designing protein interactions that occur at a very fast timescale, which no one has been able to develop systematically. We’re getting to the point of being able to engineer any function at timescales of a few seconds or less,” says Deepak Mishra, a research associate in MIT’s Department of Biological Engineering and the lead author of the new study.

Synopsis: In this talk we articulate a positive vision of the future that is both viable given what we know, and also utterly radical in its implications. We introduce two key insights that, when taken together, synergize in powerful ways. Namely, (a) the long-tails of pleasure and pain, and (b) the correlation between wellbeing, productivity, and intelligence. This informs us how to distribute resources if we want to maximize wellbeing. Given the weight of the extremes, it is important to take them into account. But because of the causal significance of more typical hedonic ranges, engineering our baseline is a key consideration. This makes it natural to break down the task of paradise engineering into three components:

Avoid negative extremes.
increase hedonic baseline, and.
achieve new heights of experience.

Continue reading “The Future of Consciousness — Andrés Gómez Emilsson” »

Turns out, altering bacteria from within could be the solution to antibiotic resistance. In an ironic twist, researchers used viruses engineered with the CRISPR-Cas system to alter bacterial defense mechanisms and edit their genomes selectively in complex environments. Significantly, the novel approach may help address the pressing issue of antibiotic resistance.

With mathematical modeling, a research team has now succeeded in better understanding how the optimal working state of the human brain, called criticality, is achieved. Their results mean an important step toward biologically-inspired information processing and new, highly efficient computer technologies and have been published in Scientific Reports.

“In particular tasks, supercomputers are better than humans, for example in the field of artificial intelligence. But they can’t manage the variety of tasks in everyday life —driving a car first, then making music and telling a story at a get-together in the evening,” explains Hermann Kohlstedt, professor of nanoelectronics. Moreover, today’s computers and smartphones still consume an enormous amount of energy.

“These are no sustainable technologies—while our brain consumes just 25 watts in everyday life,” Kohlstedt continues. The aim of their interdisciplinary research network, “Neurotronics: Bio-inspired Information Pathways,” is therefore to develop new electronic components for more energy-efficient computer architectures. For this purpose, the alliance of engineering, life and natural sciences investigates how the human brain is working and how that has developed.

Turns out, altering bacteria from within could be the solution to antibiotic resistance.

In an ironic twist, researchers used viruses engineered with the CRISPR-Cas system to alter bacterial defense mechanisms and edit their genomes selectively in complex environments. Significantly, the novel approach may help address the pressing issue of antibiotic resistance.

Meletios Verras/iStock.

Continue reading “These engineered viruses are delivering DNA to E.coli instead of killing it- here’s why” »

Traumatic brain injuries might have faded from the headlines since the NFL reached a $765 million settlement for concussion-related brain injuries, but professional football players aren’t the only ones impacted by these injuries. Each year, between 2 million and 3 million Americans suffer from traumatic brain injuries—from elderly people who fall and hit their head, to adolescents playing sports or falling out of trees, to people in motor vehicle accidents.

There are currently no treatments to stop the long-term effects of a traumatic brain injury (TBI), and accurate diagnosis requires a visit to a medical center for a CT scan or MRI, both of which involve large, expensive equipment.

UC San Diego bioengineering Professor Ester Kwon, who leads the Nanoscale Bioengineering research lab at the Jacobs School of Engineering, aims to change that. Kwon’s team is developing nanomaterials—materials with dimensions on the nanometer scale—that could be used to diagnose traumatic brain injury on the spot, be it a sports field, the scene of a car accident, or a clinical setting. They’re also engineering nanoparticles that could target the portion of the patient’s brain that was injured, delivering specific therapeutics to treat the injury and improve the patient’s long-term quality of life.

She worked in top labs at Stanford and Harvard. Now she wants to disrupt a 100-Billion-Dollar market by rejuvenating your skin using genetic engineering.

The lone volunteer in a unique study involving a gene-editing technique has died, and those behind the trial are now trying to figure out what killed him.

Terry Horgan, a 27-year-old who had Duchenne muscular dystrophy, died last month, according to Cure Rare Disease, a Connecticut-based nonprofit founded by his brother, Rich, to try and save him from the fatal condition.

Although little is known about how he died, his death occurred during one of the first studies to test a gene editing treatment built for one person. It’s raising questions about the overall prospect of such therapies, which have buoyed hopes among many families facing rare and devastating diseases.