Dr. Jamie Nicole Justice
Jamie Nicole Justice, Ph.D. is Assistant Professor in the Department of Internal Medicine Section on Gerontology and Geriatrics at Wake Forest School of Medicine. She is a member of the interdisciplinary US-based Translational Geroscience Network and Chair of the Gerontological Society of America’s Emerging Scholars and Professionals Organization.
Jamie is a translational scientist conducting aging research, from the basic biology of aging to clinical trials aimed at improving physical function and extending healthy lifespan or healthspan.
Her research training and professional work have spanned disciplines, animal models, and intervention strategies. Including:
- Development of Clinical Trials to Extend Healthy Lifespan
- Senolytics in Idiopathic Pulmonary Fibrosis: Results From a First-In-Human, Open-Label, Pilot Study
- Lipotoxicity, aging, and muscle contractility: does fiber type matter?
- Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity: Translational physiology of ageing
- Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women
- Motor function is associated with 1,25(OH)2D and indices of insulin-glucose dynamics in non-diabetic older adults
- Mouse model of behavioral tests in mice that models age-associated changes in human motor function
Jamie also received the NIH grant award Research Scientist Development Award – Research Training (K01) in 2018 on Senescent Cell Burden in Human Aging and Obesity: Functional Consequences and Reduction by Caloric Restriction.
In her current research, Jamie studies promising geroscience-guided interventions in clinical trials in older adults. This includes:
- Serving on the executive committee of the clinical trial Targeting Aging with Metformin (TAME), which is designed to facilitate U.S. regulatory approval for aging and age-related diseases as a drug target;
- Development of biomarkers of biological aging;
- Leading clinical investigations on the biological aging process cellular senescence, including clinical trials of senolytics which mitigate senescent cell burden.
Jamie is among a select group of researchers with the skills to bridge translational divides and move forward interventions targeting the biology of aging in humans. Her main topic is discussing advances, setbacks, and current approaches in translating senotherapeutic drugs to clinical trials, specifically intermittent dosing with the senolytic combination dasatinib and quercetin in older patient populations.
In addition, she has taught undergraduate and graduate level courses, completed extensive training in biostatistics, managed several comparative aging studies, and served as PI and Co-I for clinical trials in older adults using repurposed pharmaceuticals, nutraceuticals, diet, and lifestyle interventions.
Jamie is also well versed in statistical tools and MATLAB and is an avid Graphic Designer.
Jamie earned her Ph.D. in Neurophysiology of Movement and Integrative Physiology of Aging in 2013 at the University of Colorado at Boulder. She continued there with her Postdoctoral Research until 2015. Her dissertation title was Motor function: measurement, translation, and the effects of aging.
As well, she earned her Master’s Degree of Science in Integrative Physiology in 2012 at the University of Colorado at Boulder. She earned her B.A. at the University of Colorado at Boulder in 2007 and her A.D. at Blue Ridge Community College in 2002.
Her second Postdoctoral Research was at Wake Forest School of Medicine from 2015, where she gained a translational research background (mice, human, and nonhuman primate), studying interventions with the potential to prevent, delay, or treat age-related functional decline and chronic diseases. In 2017, Jamie became an Assistant Professor at the Wake Forest School of Medicine.
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