Professor George Perry

George Perry, Ph.D., HonD, FAAAS, IMBO, RAC, AMC, ACL, FLS, FSB, CBiol, FRCPath, RSC, FMSA, FRSC, CChem, FRSB, CBio, CSci, FRSM, CSciTeach, FRSA, FABAP, FRMS, FWAMS is Professor of Biology and Chemistry, Semmes Foundation Distinguished University Chair in Neurobiology, and former Dean of Sciences at The University of Texas at San Antonio.

He is Adjunct Professor of Pathology and Neurosciences, Case Western Reserve University and Affiliate Professor of Chemistry and Biochemistry, University of Alaska. He is recognized in the field of Alzheimer’s disease research particularly for his work on oxidative stress. Since 2011, he has been the Chief Scientific Officer at Neurotez guiding scientific efforts to develop a leptin therapeutic for Alzheimer’s disease and cofounded Stop Alzheimers Corp in 2014 for raising awareness of Alzheimer’s Disease.

George is distinguished as one of the top 20 Alzheimer’s disease researchers with over 1500 publications, one of the top 100 most-cited scientists in Neuroscience & Behavior, one of the top 25 scientists in Free Radical Research, and one of the top 10 Alzheimer’s disease researchers. He has been cited over 99,900 times (H=157) and is recognized as an ISI highly cited researcher.

He serves as editor for several journals including Journal of Biomedicine and Biotechnology and Microscopy Research and Technique, is on the editorial board of many journals including the American Journal of Pathology, Journal of Biological Chemistry, Brain Pathology, Antioxidants and Redox Signaling, Brain Research, Alzheimer and Dementia, Frontiers in Aging Neuroscience, U.S. Neurology, Metabolic Brain Disease, Biochemical Pharmacology, Cellular and Molecular Neurobiology, and Scientific Reports (Nature), and is Editor-in-Chief of Journal of Alzheimer’s Disease and Journal of Alzheimer’s Disease Reports. He also served as President of the American Association of Neuropathologists.

George serves on more than 130 Advisory Boards and as a member of Boards of Directors or as Chief Scientist Officer, among others at Synaptogenix and Alzheimer Research and Prevention Foundation.

He is a member of more than 30 National and more than 80 International Review Boards. He has been an invited Lecturer and Speaker to more than 500 lectures and seminars globally. George holds 4 patents, among these areOlfactory neuron cultures and methods of making and using the same and Ubiquilin, a presenilin interactor and methods of using same.

George’s studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer’s disease. He has shown that oxidative damage is the initial cytopathology in Alzheimer’s disease. He is working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals.

His current studies focus on (i) the mechanism for RNA-based redox metal binding; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; (iii) the role of redox active metals in mediating prooxidant and antioxidant properties; (iv) the signal transduction pathways altered in Alzheimer’s disease that allow neurons to evade apoptosis; and (v) mechanism of phosphorylation control of oxidative damage to neurofilament proteins.

George edited Advances in Behavioral Biology 34: Alterations in the Neuronal Cytoskeleton in Alzheimer Disease, coedited Alzheimer’s Disease: A Century of Scientific And Clinical Research, Ubiquitin is Detected in Neurofibrillary Tangles and Senile Plaque Neurites of Alzheimer Disease Brains, Alzheimer’s Disease: New Beginnings, and coauthored Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease, RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease, Mitochondrial Abnormalities in Alzheimer’s Disease, Evidence that the β-Amyloid Plaques of Alzheimer’s Disease Represent the Redox-silencing and Entombment of Aβ by Zinc, and Parkinson’s Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons.

George earned his Bachelor’s Degree of Arts in Zoology from the University of California, Santa Barbara in 1974 and his Ph.D. in Marine Biology under David Epel at the Scripps Institution of Oceanography in 1979 with the Thesis Studies on calcium-stimulated oxidations in the sea urchin egg.

He was a postdoctoral fellow in the Department of Cell Biology in the laboratories of Drs. Bill Brinkley and Joseph Bryan at Baylor College of Medicine where he laid the foundation for his observations of abnormalities in cell structures. In 1982, Perry joined the faculty of Case Western Reserve University, where he performed the majority of his research and currently holds an adjunct appointment.

He was elected a Fellow of the American Association for the Advancement of Science in 1998, Zenith Fellow, Alzheimer’s Association in 2007, and Microscopy Society of America, Fellow (FMSA) in 2011. George is internationally recognized and was among others elected fellow of the Royal Society of Chemistry, Royal Society of Medicine, Royal College of Pathologists, Society of Biology, and the Linnean Society of London — all in 2011.

He is Foreign Correspondent Member of the Spanish Royal Academy of Sciences since 2009 and was elected Member of the Iberoamerican Molecular Biology Organization in 2008. He received an honorary doctorate from Universidad Arturo Prat, Chile in 2007, became a corresponding Foreign Member of Academia Mexicana de Ciencias in 2010, and of the Academia de Ciêncas de Lisboa in 2011. He is also a recipient of the National Plaque of Honor from the Republic of Panama Ministry of Science and Technology.

He received the Distinguished Professional Mentor Award, Society for the Advancement of Chicanos and Native Americans in Sciences in 2010, and the Senior Investigator Award for the International College of Geriatric Psychoneuropharmacology in 2011. He is Member of the Dana Alliance for Brain Initiatives.

In 2014 he was elected Fellow of the Royal Society of Arts, Manufactures and Commerce (FRSA), Royal Microscopical Society (FRMS). He was elected Fellow of the Academy of Biotechnology and Pharmacy (FABAP), India in 2015.

In 2017, George was elected Fellow of the World Academy of Medical Sciences (FWAMS), EU Academy of Sciences, and in 2018 he became Conselho da Diaspora Portuguesa.

Between 2019 to 2021, he was awarded the Cure Coin Award, became Distinguished Texas Scientist of Texas Academy of Science, and received the Rous-Whipple Award from the American Society of Investigative Pathology.

Read George’s presentations at SlideShare.

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