Results from a recent clinical trial led by physicians at Emory University and Grady Health System indicate that a twice-yearly injection of Lenacapavir offers a 96% reduced risk of HIV infection overall, significantly more effective than the daily oral PrEP.
“In vivo measurement of basement membrane stiffness showed that ISCs reside in a more rigid microenvironment at the bottom of the crypt,” the article’s authors wrote. “Three-dimensional and two-dimensional organoid systems combined with bioengineered substrates and a stretching device revealed that PIEZO channels sense extracellular mechanical stimuli to modulate ISC function.”
The paper’s first author is Meryem Baghdadi, PhD, a former researcher at SickKids, and the paper’s senior authors are Tae-Hee Kim, PhD, a senior scientist at SickKids, and Danijela Vignjevic, PhD, a research director at Institut Curie. The study they led expanded on the work of one of the paper’s co-authors, Xi Huang, PhD, a senior scientist at SickKids.
In 2018, Huang found that PIEZO ion channels influence tumor stiffening in brain cancer. Inspired by this research, the collaborators in the current study set out to explore how stem cells in the intestines use PIEZO channels to stay healthy and function properly.
“These sites act like Velcro with different colors – designed so that only strands with matching ‘colors’ (in fact, complementary DNA sequences) can connect,” said Dr. Luu.
This method allows researchers to construct customizable, highly specific architectures that can perform intricate tasks at the molecular level.
One of the most promising applications of this technology is its ability to create nanorobots capable of delivering drugs directly to targeted areas within the body.
Engineers harness focused ultrasound to revolutionize CRISPR’s capabilities to treat countless diseases.
Evaluating the speed at which viruses spread and transmit across host populations is critical to mitigating disease outbreaks. A study published December 3 in PLOS Biology by Simon Dellicour at the University of Brussels (ULB), Belgium, and colleagues evaluate the performance of statistics measuring how viruses move across space and time in infected populations.
Genomic sequencing allows epidemiologists to examine the evolutionary history of pathogenic outbreaks and track the spatial movement of an outbreak. However, the sampling intensity of genomic sequences can potentially impact the accuracy of dispersal insights gained through these evolutionary approaches.
In order to assess the impact of the sampling size, researchers simulated the spread of several pathogens to evaluate three dispersal metrics estimated from the analysis of viral genomes: a lineage dispersal velocity (the speed at which lineages spread), a diffusion coefficient (how fast lineages invade space), and an isolation-by-distance signal (how genomic sequences of a population become less similar over geographic distance) metric.
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD
Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.
Continue reading “What Time Of Day Is Best For Red Light Therapy? Glen Jeffery, PhD” »
The Adaptive Immunity and Immunoregulation Section (AIIS) in the Laboratory of Allergic Diseases at #NIAID is seeking an exceptional candidate for a postdoctoral fellowship position.
The National Institute of Allergy and Infectious Diseases (NIAID), one of the largest institutes in the National Institutes of Health (NIH), and part of the Department of Health and Human Services (HHS), conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.
A postdoctoral fellowship position is available immediately in the Adaptive Immunity and Immunoregulation Section (AIIS) within the Laboratory of Allergic Diseases, NIAID. AIIS seeks highly motivated and collaborative candidates with a strong publication record who are capable of independent reasoning and excited about learning new technologies.
AIIS aims to define the cellular and molecular mechanisms controlling the balance between protective and pathogenic adaptive immune responses to allergens and pathogens. With a particular focus on memory T and B cells and T follicular helper (Tfh) cells, the lab utilizes state-of-the-art cellular and molecular approaches, including in vivo models of infection and allergy, multi-color flow cytometry, adoptive transfer experiments, cell fate tracking experiments, bone marrow chimeras, parabiosis surgery, imaging, conditional knockout and transgenic models, RNA-Seq, and single-cell technologies to characterize memory B-and T-cell responses in different models of food and respiratory allergens and infections.
The Dutch scientist designs the world’s smallest machines, including light-activated drugs to improve treatments for cancer and infection.
Scientists developed a DNA-based molecular controller that autonomously directs the assembly and disassembly of molecular robots, a key approach with potential applications in medicine and nanotechnology.
Thanks to CRISPR, medical specialists will soon have unprecedented control over how they treat and prevent some of the most challenging genetic disorders and diseases.
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a Nobel Prize-winning gene-editing tool, already widely used by scientists to cut and modify DNA sequences to turn genes on and off or insert new DNA that can correct abnormalities. CRISPR uses an enzyme known as Cas9 to cut and alter DNA.
Engineers at the USC Alfred E. Mann Department of Biomedical Engineering have now developed an update to the tool that will allow CRISPR technology to be even more powerful with the help of focused ultrasound.
